The stau exchange contribution to muon g-2 in the decoupling solution

We study the possibility that the lepton-flavor changing process can induce the suitable magnitude of the muon anomalous magnetic moment (g_\mu -2) in the decoupling solution to the flavor problem in the minimal supersymmetric standard model. Our analyses introduce the flavor mixings of left- and right-handed stau and smuon phenomenologically. It is found that if both the left- and right-handed sleptons have sizable flavor mixings, the correction to g_\mu -2 from the lighter slepton can reach to 10^{-9} while the correction to the branching ratio of \tau \to \mu \gamma satisfies the current experimental bound. On the other hand, when only the left-handed or right-handed sleptons have the large flavor mixing, the suitable magnitude of the correction to g_\mu-2 is not realized owing to the experimental bound of \tau \to \mu \gamma.Comment: 11 pages, latex2e with axodraw.sty, comments and reference adde

Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase on serum lipoproteins and ubiquinone-10 levels in patients with familial hypercholesterolemia

We studied the effects of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (KMG-CoA) reductase, on serum levels of lipoproteins and ubiquinone-10 in seven heterozygous patients with familial hypercholesterolemia. ML-236B was given at doses of 30 to 60 mg per day for 24 weeks. Serum cholesterol decreased from 390 ± 9 to 303 ± 8 mg per deciliter (10.1 ± 0.2 to 7.88 ± 0.2 mmol per liter, mean ± S.E.M.; P<0.001), and serum triglyceride decreased from 137 ± 18 to 87 ± 9 mg per deciliter (1.55 ± 0.20 to 0.98 ± 0.1 mmol per liter; P<0.05). Intermediate-density-lipoprotein (IDL) cholesterol, IDL triglyceride, low-density-lipoprotein (LDL) cholesterol, and LDL triglyceride decreased significantly (P<0.01, P<0.02, P<0.001, and P<0.001, respectively). However, there were no significant changes in very-low-density-lipoprotein (VLDL) cholesterol and triglyceride or high-density-lipoprotein (HDL) cholesterol. Serum ubiquinone-10 levels did not change, and LDL levels of ubiquinone-10 decreased by 50 per cent, from 0.39 ± 0.07 to 0.20 ± 0.01 μg per milliliter (P<0.05). No adverse effects were observed. We conclude that ML-236B is effective in lowering serum cholesterol without lowering serum ubiquinone-10 in heterozygous patients with familial hypercholesterolemia

Development of a multi-pixel photon sensor with single-photon sensitivity

A multi-pixel photon sensor with single-photon sensitivity has been developed, based on a technology of a hybrid photo-detector (HPD) consisting of a photocathode and a multi-pixel avalanche diode (MP-AD). The developed HPD has a proximity focused structure, where a photocathode and an MP-AD are facing each other with a small gap of 2.5 mm. The MP-AD, which has an effective area of 16x16 mm2 composed of 8x8 pixels, has been specially designed for the HPD. The gain of the HPD reaches 5x10^4, sufficiently high to detect single photons with a timing resolution better than 100 ps. Number of photoelectrons up to four can be clearly identified in a pulse-height spectrum as distinct peaks, thanks to the low noise characteristics of the HPD. It is also demonstrated that the HPD can be operated with good performance in a magnetic field as high as 1.5 TComment: 39 pages, 22 figures, submitted to Nucl. Intr. and Meth.

Effects of ML-236B (compactin) on sterol synthesis and low density lipoprotein receptor activities in fibroblasts of patients with homozygous familial hypercholesterolemia

金沢大学大学院医学系研究科　We studied biochemical genetics of low density lipoprotein (LDL) receptor mutations in fibroblasts from six homozygous and five heterozygous patients with familial hypercholesterolemia (FH). Three of six homozygotes are receptor-negative type and the other three homozygotes are receptor-defective type. In the cells from three receptor-negative homozygotes, the receptor binding, internalization, and degradation of 125I-LDL were 0.5 ± 0.3 ng/mg protein (mean ± SEM), 14 ± 8 and 8 ± 6 ng/mg protein per 6 h (four normal cells; 44 ± 3, 386 ± 32, and 1,335 ± 214 ng/mg protein per 6 h), respectively. In the cells from three receptor-defective homozygotes, the receptor binding, internalization, and degradation of 12:5I-LDL were 6 ± 2, 29 ± 8, and 90 ± 32 ng/mg protein per 6 h, respectively. In these six homozygotes, two pairs of siblings are included. Two siblings in the same family were classified as receptor-negative and two siblings in another family were classified as receptor-defective. The receptor-negative phenotypes and the receptor-defective phenotypes bred true in individual families. The cells from five heterozygotes showed ~46% of the normal activities of receptor. ML-236B, competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), completely inhibited the incorporation of [14C]acetate into digitonin-precipitable sterols in fibroblasts from normal subjects and heterozygous and homozygous patients with FH with the concentration of 0.5 μg/ml. However, at 0.05 μg/ml of ML-236 B sterol synthesis in fibroblasts from homozygotes was not completely suppressed in contrast to normal and heterozygous cells. Moreover, after preincubation with 0.05 μg/ml of ML-236B for 24 h in medium containing lipoproteins, sterol synthesis in the cells from receptor-negative homozygote showed 75% of the initial activity compared with that of 25% without preincubation. In the cells from a normal subject and heterozygote, sterol synthesis was inhibited even after preincubation. These results suggest that (a) the inhibitory effect of ML-236B is overcome in homozygote cells by their high intracellular levels of HMG-CoA reductase and (b) that a higher dose of ML-236B may be required to lower serum cholesterol levels in FH homozygotes than in heterozygotes

New pixel detector concept DuTiP for Belle II upgrade and the ILC with an SOI technology

International audienceBelle II detector upgrade is being discussed aiming to collect five times larger integrated luminosity of 250 ab−1. The beam background level is expected five times higher than current design, thus a new pixel vertex detector with faster readout should be developed. We have invented a new pixel detector concept DuTiP for the Belle II upgrade which can be also used for the International Linear Collider (ILC) with small modifications. To realize the DuTiP concept, an SOI technology is chosen as a baseline with a pixel size of 35μm×35μm. The DuTiP concept and its application to a monolithic pixel detector in an SOI technology are explained

Effects of ML-236b (compactin) on sterol synthesis and low density lipoprotein receptor activities in fibroblasts of patients with homozygous familial hypercholesterolemia. J Clin Invest

A B S T R A C T We studied biochemical genetics of low density lipoprotein (LDL) receptor mutations in fibroblasts from six homozygous and five heterozygous patients with familial hypercholesterolemia (FH 29 December 1980. 1532 tion of 0.5 Ag/ml. However, at 0.05 ,ug/ml of sterol synthesis in fibroblasts from homozygotes was not completely suppressed in contrast to normal and heterozygous cells. Moreover, after preincubation with 0.05 ,ug/ml of ML-236B for 24 h in medium containing lipoproteins, sterol synthesis in the cells from receptornegative homozygote showed 75% of the initial activity compared with that of 25% without preincubation. In the cells from a normal subject and a heterozygote, sterol synthesis was inhibited even after preincubation. These results suggest that (a) the inhibitory effect of ML-236B is overcome in homozygote cells by their high intracellular levels of HMG-CoA reductase and (b) that a higher dose of ML-236B may be required to lower serum cholesterol levels in FH homozygotes than in heterozygotes