Newly Developed Piperidinyl Sulfamides as Tyrosyl-DNA Phosphodiesterase 1 (Tdp 1) Inhibitors, and Study of Anticancer Activity of Piperidinyl Sulfamides Derivatives and Seven-Membered Cyclic Sulfamide Analogs Using the National Cancer Institute 60 Human Cancer Cell Line (NCI 60) Screen

Sulfur containing compounds have become increasingly important in the development of biological agents for pharmaceutical and industrial use. Cyclic sulfamides, in particular, have been found to be useful as cancer, HIV protease inhibitors and other therapeutic treatments. As the need for new and improved inhibitors is warranted by the serious cancer disease, the search for new synthetic pathways to access novel sulfamides is ongoing. To this end, the work discussed herein focuses on the synthesis of newly developed sulfamides utilizing the reductive amination and Mitsunobu reaction to generate novel chiral amino ester containing sulfamide compounds. These compounds are being screened for their biological activities as Tyrosyl-DNA phosphodiesterase 1 (Tdp 1) inhibitors and anti-cancer drugs. Initially, reductive amination, CSI coupling, and Mitsunobu reaction were employed to generate piperidinyl sulfamides, and these compounds were screened for Tdp1 inhibition. These compounds were submitted to Dr. Pomier's group at NIH to carry out the gel study to select active compounds. We also checked the binding effect through the protein docking study. In addition, these sulfamide compounds were screened from NCI 60-cancer cell lines to check the bioactivity and in vitro cytotoxicity evaluation. To understand anti-cancer activity of cyclic sulfamides, symmetric and unsymmetric seven-membered sulfamides compounds were tested in 60 cancer cell line from the National Cancer Institute. These compounds were made when I studied for the Master degree at the University of Kansas. RCM was employed to generate symmetric seven-membered cyclic sulfamides similar in structure to known active HIV protease inhibitor DMP 323. Functionalization of these compounds employing "robust S-linchpins" in conjunction with RCM yields an array of new S-heterocycles. Further work in sulfamides employed a combination of RCM with different coupling routes to generate unsymmetric seven-membered cyclic sulfamides with varied substitution in their P1/P1' and P2/P2' periphery in attempts to broaden the scope of this chemistry and to generate new biologically active compounds

VR/AR head-mounted display system based measurement and evaluation of dynamic visual acuity

This study evaluated the dynamic visual acuity of candidates by implementing a King–Devick (K-D) test chart in a virtual reality head-mounted display (VR HMD) and an augmented reality head-mounted display (AR HMD). Hard-copy KD (HCKD), VR HMD KD (VHKD), and AR HMD KD (AHKD) tests were conducted in 30 male and female candidates in the age of 10S and 20S and subjective symptom surveys were conducted. In the subjective symptom surveys, all except one of the VHKD questionnaire items showed subjective symptoms of less than 1 point. In the comparison between HCKD and VHKD, HCKD was measured more rapidly than VHKD in all tests. In the comparison between HCKD and AHKD, HCKD was measured more rapidly than AHKD in Tests 1, 2, and 3. In the comparison between VHKD and AHKD, AHKD was measured more rapidly than VHKD in Tests 1, 2, and 3. In the correlation analyses of test platforms, all platforms were correlated with each other, except for the correlation between HCKD and VHKD in Tests 1 and 2. There was no significant difference in the frequency of errors among Tests 1, 2, and 3 across test platforms. VHKD and AHKD, which require the body to be moved to read the chart, required longer measurement time than HCKD. In the measurements of each platform, AHKD was measured closer to HCKD than VHKD, which may be because the AHKD environment is closer to the actual environment than the VHKD environment. The effectiveness of VHKD and AHKD proposed in this research was evaluated experimentally. The results suggest that treatment and training could be performed concurrently through the use of clinical test and content development of VHKD and AHKD

Delayed rupture of a pseudoaneurysm in the brachial artery of a burn reconstruction patient

A brachial artery pseudoaneurysm is a rare but serious condition that can be limb threatening. A number of reports have found that it may be the result of damage to the blood vessels around the brachial artery, either directly or indirectly, due to trauma or systemic diseases. We present our experience of delayed pseudoaneurysm rupture of the brachial artery in a rehabilitation patient with burns of the upper extremity who underwent fasciotomy and musculocutaneous flap coverage. We also provide a review of the brachial artery pseudoaneurysm

Network Analysis of TV-Viewing Patterns in Multi-Channel Circumstances

Translated from the article published in Korean Journal of Broadcasting vol. 24, no. 6, 2010, with permission from the Korean Association for Broadcasting and Telecommunication Studies.This study uses the network analysis method to overcome limitations of previous research that had inaccurately examined the phenomena of fragmentation and polarization in TV viewing behaviors. First of all, viewer ratings were analyzed, which consisted of 298 panels in 2004 and 2007. The benefit of this panel data was not only to secure the validity and credibility of the data, but also to figure out the change of viewing patterns. The result of network centralization and centrality analysis was that fragmentation became stronger as the number of channels increased. In other words, audiences dispersed to professional and specialized channels. However, they came together from terrestrial broadcastings to other channels again. The re-concentration phenomenon appeared apparently in drama channels that belonged to terrestrial (non-satellite or cable) broadcastings. In addition, sub-network analysis showed that small but loyal viewer groups kept on increasing. This result indicates the depth of polarization, which means audiences have a tendency to view common genre programs according to their preference

Tracking the Mn diffusion in the carbon-supported nanoparticles through the collaborative analysis of atom probe and evaporation simulation

Carbon-supported nanoparticles have been used widely as efficient catalysts due to their enhanced surface-to-volume ratio. To investigate their structure-property relationships, acquiring 3D elemental distribution is highly required. Here, the carbon-supported Pt, PtMn alloy, and ordered Pt3Mn nanoparticles are synthesized and analyzed with atom probe tomography as model systems. The significant difference of Mn distribution after the heat-treatment was found. Finally, the field evaporation behavior of the carbon support was discussed and each acquired reconstruction was compared with computational results from the evaporation simulation. This paper provides a guideline for studies using atom probe tomography on the heterogeneous carbon-nanoparticle system that leads to insights toward to a wide application in carbon-supported nano-catalysts