Economical And Systematical Evaluation On Rainfall Harvesting System (Case Study : Rainfall Harvesting System Designed In Taebaek City, Republic Of Korea)

Recently, climate change has caused drought to become more frequent and is becoming one of the serious natural disasters, resulting damages in infrastructure facilities, economy and private property losses etc. Taebaek city of Gangwon-do lies in the northeast Korean Peninsula along the steep mountain slopes, all the way to the sea. Thu, this city exhibit the Marine Climatic Characteristics. During the past 10 years, the average rainfall of Taebaek city is 849.9mm/year, which is less than the average rainfall for the whole country (1,274mm/year). This research is still ongoing. The next assessment will be on the construction cost of rainfall harvesting system (through school types) and the LCC (Life Cycle Cost) of Maintenance Administration. After which, discussion for the impacts Rainfall Harvesting System on the water supply self-sufficiency of Taeback city will be made. Lastly, conclusion on the future economic benefit for Taeback city will be given. ACKNOWLEDGEMENT This research was supported by a grant(12-TI-C01) from Advanced Water Management Research Program funded by Ministry of Land, Infrastructure and Transport of Korean governmen

Regional Water Balance Assessment - Case Study : Youngjongdo Island In Incheon, Korea

In Korea repeatedly experiences floods and droughts that cause traumatic environmental conditions with huge economic impact. With an approach and solution such as Smart Water Grid these problems can be alleviated. Tapping into the retention ponds behind dams, rainfall harvest facilities in urban areas and any other structures installed to store rainfall water during flood events will mitigate the damage of flooding and provide a new source of national water resources. Similarly, purified waste water, ground water and desalinated sea water can also feasible to use as alternative water resources. In this study, the water balance assessment model is being developed as a Smart Water Grid research. In fact, large proportions of water resources in Korea rely on a river fresh water. Also in the Youngjongdo island, tap water from water purification plant which use original source from the Han river. However the water supply system in the island is quite dangerous since the water purification plant is located in Incheon city and the water comes to island through the sea and no other source is used in the island. Therefore, once the accident at main water pipe in the sea, no water is available in this island. Information on water availability and water needs are crucial to identify hot spots of quantitative pressures on water resources. In this study, all available alternative water sources are calculated by the model developed through this study. Several physical and stochastic models on hydraulic and hydrological approaches to investigate physical characteristics of catchments. Achknowledgement This research was supported by a grant (12-TI-C01) from Advanced Water Management Research Program funded by Ministry of Land, Infrastructure and Transport of Korean government

An Analysis Of Discharge And Water Level Changes Due To Weir (In The Case Of The Waegwan And Nakdong Station In South Korea)

ABSTRACT Our country, Korea, lacks the per capita water endowment because of the high population density and geographical characteristics. Therefore, The 4 Rivers Project has been promoted since 2009. In order to control effectively drought or floods caused by abnormal climate and strong rainfall in summer, it was done and completed in 2013. The Nakdong River is the longest in the 4 Rivers Project, which it was conducted among the country\u27s major rivers, and a lot of hydraulic structures were installed. we selected Nakdong and Weagwan stations which are located in the Nakdong River. Because the change was smaller there with the inflow of tributaries flow than elsewhere. And many hydraulic structures were installed between Nakdong and Weagwan stations, which used T/M machine to collect real-time data. In this study, we compared and analyzed the flow change of real-time and water level data of prior to weir installation on May, June, July, 2009 and completion of weir installation on May, June, July , 2013. The original purpose of installing the weir is well-kept. After installation of Hydraulic structures(weir), the discharge difference between the Nakdong Station and Weagwan Station was reduced , and both of Nakdong and Weagwan stations are almost maintain a constant value of water level without being affected by rainfall. Also, we could confirm that the maximum water-level variation is decreased after installation of the weir. Based on this, we judged that hydrological effects on drought or floods due to abnormal weather were decreased by the time of weir installation. ACKNOWLEDGEMENT This research was supported by a grant(12-TI-C01) from Advanced Water Management Research Program funded by Ministry of Land, Infrastructure and Transport of Korean governmen

Regional water balance assessment - Case study

행사명 : 11th International Conference on Hydroinformatic

Excellent Switching Performances of TiON/HZO/MoS2 Ferroelectric Diode

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Additive effect of bFGF and selenium on expansion and paracrine action of human amniotic fluid-derived mesenchymal stem cells

Abstract Background Mesenchymal stem cell-derived conditioned medium (MSC-CM) has emerged as a promising cell-free tool for restoring degenerative diseases and treating traumatic injuries. The present study describes the effect of selenium as a reactive oxygen species (ROS) scavenger and its additive effect with basic fibroblast growth factor (bFGF) on in vitro expansion of amniotic fluid (AF)-MSCs and the paracrine actions of AF-MSC-CM as well as the associated cellular and molecular mechanisms. Methods In this study, we obtained CM from human AF-MSCs cultured with selenium. The stemness of selenium-treated AF-MSCs was evaluated by cell growth and differentiation potential. Human fibroblasts were treated with AF-MSC-CM and analyzed for cell signaling changes. For in vivo wound healing assay, ICR mice with a full-thickness skin wound were used. Results Selenium played a critical role in in vitro expansion of AF-MSCs through activation of the AKT-ERK1/2, Smad2, and Stat3 signaling pathways along with inactivation of GSK3β. When administered together with bFGF, it showed remarkable effect in inhibiting ROS accumulation and preserving their multipotency. Proliferation and migration of human dermal fibroblasts and in vivo wound healing were improved in the CMs derived from AF-MSCs exposed to selenium and bFGF, which was caused by the Smad2, AKT-MEK1/2-ERK, and NFκB signaling triggered by the paracrine factors of AF-MSCs, such as TGF-β, VEGF, and IL-6. Our results suggest the following: (a) supplementation of selenium in AF-MSC culture contributes to in vitro expansion and preservation of multipotency, (b) ROS accumulation causes progressive losses in proliferative and differentiation potential, (c) the separate activities of bFGF and selenium in MSCs exert an additive effect when used together, and (d) the additive combination improves the therapeutic effects of AF-MSC-derived CMs on tissue repair and regeneration. Conclusion Antioxidants, such as selenium, should be considered as an essential supplement for eliciting the paracrine effects of MSC-CMs

Hypoxic Conditioned Medium from Human Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Skin Wound Healing through TGF-β/SMAD2 and PI3K/Akt Pathways

In a previous study, we isolated human amniotic fluid (AF)-derived mesenchymal stem cells (AF-MSCs) and utilized normoxic conditioned medium (AF-MSC-norCM) which has been shown to accelerate cutaneous wound healing. Because hypoxia enhances the wound healing function of mesenchymal stem cell-conditioned medium (MSC-CM), it is interesting to explore the mechanism responsible for the enhancement of wound healing function. In this work, hypoxia not only increased the proliferation of AF-MSCs but also maintained their constitutive characteristics (surface marker expression and differentiation potentials). Notably, more paracrine factors, VEGF and TGF-β1, were secreted into hypoxic conditioned medium from AF-MSCs (AF-MSC-hypoCM) compared to AF-MSC-norCM. Moreover, AF-MSC-hypoCM enhanced the proliferation and migration of human dermal fibroblasts in vitro, and wound closure in a skin injury model, as compared to AF-MSC-norCM. However, the enhancement of migration of fibroblasts accelerated by AF-MSC-hypoCM was inhibited by SB505124 and LY294002, inhibitors of TGF-β/SMAD2 and PI3K/AKT, suggesting that AF-MSC-hypoCM-enhanced wound healing is mediated by the activation of TGF-β/SMAD2 and PI3K/AKT. Therefore, AF-MSC-hypoCM enhances wound healing through the increase of hypoxia-induced paracrine factors via activation of TGF-β/SMAD2 and PI3K/AKT pathways

sj-tif-2-tej-10.1177_20417314231226105 – Supplemental material for Therapeutic potential of luteolin-loaded poly(lactic-co-glycolic acid)/modified magnesium hydroxide microsphere in functional thermosensitive hydrogel for treating neuropathic pain

Supplemental material, sj-tif-2-tej-10.1177_20417314231226105 for Therapeutic potential of luteolin-loaded poly(lactic-co-glycolic acid)/modified magnesium hydroxide microsphere in functional thermosensitive hydrogel for treating neuropathic pain by So-Yeon Park, Joon Hyuk Jung, Da-Seul Kim, Jun-Kyu Lee, Byeong Gwan Song, Hae Eun Shin, Ji-Won Jung, Seung-Woon Baek, Seungkwon You, Inbo Han and Dong Keun Han in Journal of Tissue Engineering</p

sj-docx-1-tej-10.1177_20417314231226105 – Supplemental material for Therapeutic potential of luteolin-loaded poly(lactic-co-glycolic acid)/modified magnesium hydroxide microsphere in functional thermosensitive hydrogel for treating neuropathic pain

Supplemental material, sj-docx-1-tej-10.1177_20417314231226105 for Therapeutic potential of luteolin-loaded poly(lactic-co-glycolic acid)/modified magnesium hydroxide microsphere in functional thermosensitive hydrogel for treating neuropathic pain by So-Yeon Park, Joon Hyuk Jung, Da-Seul Kim, Jun-Kyu Lee, Byeong Gwan Song, Hae Eun Shin, Ji-Won Jung, Seung-Woon Baek, Seungkwon You, Inbo Han and Dong Keun Han in Journal of Tissue Engineering</p

Highly Pure and Expandable PSA-NCAM-Positive Neural Precursors from Human ESC and iPSC-Derived Neural Rosettes

<div><p>Homogeneous culture of neural precursor cells (NPCs) derived from human pluripotent stem cells (hPSCs) would provide a powerful tool for biomedical applications. However, previous efforts to expand mechanically dissected neural rosettes for cultivation of NPCs remain concerns regarding non-neural cell contamination. In addition, several attempts to purify NPCs using cell surface markers have not demonstrated the expansion capability of the sorted cells. In the present study, we show that polysialic acid-neural cell adhesion molecule (PSA-NCAM) is detected in neural rosette cells derived from hPSCs, and employ PSA-NCAM as a marker for purifying expandable primitive NPCs from the neural rosettes. PSA-NCAM-positive NPCs (termed hNPC^PSA-NCAM+) were isolated from the heterogeneous cell population of mechanically harvested neural rosettes using magnetic-based cell sorting. The hNPC^PSA-NCAM+ extensively expressed neural markers such as Sox1, Sox2, Nestin, and Musashi-1 (80∼98% of the total cells) and were propagated for multiple passages while retaining their primitive characteristics in our culture condition. Interestingly, PSA-NCAM-negative cells largely exhibited characteristics of neural crest cells. The hNPC^PSA-NCAM+ showed multipotency and responsiveness to instructive cues towards region-specific neuronal subtypes <em>in vitro</em>. When transplanted into the rat striatum, hNPC^PSA-NCAM+ differentiated into neurons, astrocytes, and oligodendrocytes without particular signs of tumorigenesis. Furthermore, Ki67-positive proliferating cells and non-neural lineage cells were rarely detected in the grafts of hNPC^PSA-NCAM+ compared to those of neural rosette cells. Our results suggest that PSA-NCAM-mediated cell isolation provides a highly expandable population of pure primitive NPCs from hPSCs that will lend themselves as a promising strategy for drug screening and cell therapy for neurodegenerative disorders.</p> </div