Analysis of Transverse Mixing Using Natural Tracers Continuously Introduced from Tributaries

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

Modulation of A375 human melanoma cell proliferation and apoptosis by nitric oxide

The present study aimed to assess the effect of NO• on melanoma A375 cell growth and apoptotic cell death. Trypan blue exclusion assay was employed to detect the cytotoxicity induced by controlled steady-state concentrations (given in µM • min) of NO•. The characteristics of the cellular cell cycle and apoptosis in NO•-treated A375 cells were also analyzed by Annexin V/PI and DNA fragmentation assays. Western blotting was applied to detect the expression of apoptosis-related proteins (p53, Bax, Fas, DR5, caspase-3 and -9, and PARP). When exposed to preformed 100% NO• for 8 h reactor system, a cumulative dose of 3360 μM • min reduced the viability by 22% 24 h after treatment and promoted apoptosis, 2.9- and 12.2-folds 24 and 48 h after treatment higher than the argon control, respectively. Cell cycle analysis 48 h after treatment revealed S-phase arrest in cells treated with 3360 μM • min NO•. It was also observed that the expression of p53, DR5, caspase 9 and PARP increased significantly upon NO• treatment. In addition, the present study assessed the inhibitory effects of endogenous NO• on the proliferation of human melanoma cells by employing specific (AMG, 1400W and/or SMTC) and nonspecific (NMA) NO• synthase (NOS) inhibitors resulting in melanoma cell growth inhibition; the highest cytotoxic effect was seen when inducible NOS inhibition by 1 mM 1400W treatment. Collectively, the present data suggest that NO• is involved in a key mechanism limiting melanoma proliferation and apoptosis, which may play in improving the efficacy of melanoma treatment

Changes in the Outdoor Wear Market: Focused on the South Korean Market

People have become interested in wellness and health, which has led to well-being trends and increased participation in activities. Therefore, the outdoor wear market has shown growth for several years. However, the outdoor wear market of South Korea is becoming saturated. Moreover, Outdoor wear consumers are tired of same design products. The sportswear companies are trying to develop athleisure products. Therefore, it is time to develop outdoor products for emotional approach. According to results, when consumers purchase outdoor wear, they consider the functionality of the materials more than they do when purchasing ordinary clothes. Outdoor wear consumers\u27 pursued images were classified into three types: urban, minimalist, and active. Outdoor wear selection criteria were classified into two types: instrumental function and expressive function. Outdoor wear brands need to qualify their products functionally and meet their segmented consumers\u27 demands by developing products depending on their image from the planning stage

Dual Therapy with Cidofovir and Mirtazapine for Progressive Multifocal Leukoencephalopathy in a Sarcoidosis Patient

Background: Progressive multifocal leukoencephalopathy (PML) is a demyelinating central nervous system disease caused by JC virus (JCV) reactivation in immunocompromised patients. The disease course of PML is often progressive, fatal and at present, there are few reports on successful treatment outcomes. Case Report: A 45-year-old man with systemic sarcoidosis presented with rapidly progressive dementia and right hemiparesis. The patient was diagnosed with PML as confirmed via brain biopsy and JCV PCR. With a combination treatment of cidofovir and mirtazapine, there was significant improvement of neurological symptoms without measurable functional deficit. Conclusion: This case suggests that dual therapy with cidofovir and mirtazapine might be an effective treatment option in PML patients with sarcoidosis

The Fit between Client IT Capability and Vendor Competence and Its Impact on Outsourcing Success

This study investigates the impact of client firm’s IT capability, vendor firm’s competence and their fit on the outsourcing success. In theory building, by concretizing the concepts of IT capability and competence based on the resource-based view, the importance of fit between the client’s IT capability and the vendor’s competence is emphasized. We then hypothesize that both factors are stronger together than the individual impact of either the client’s IT capability or the vendor’s competence. For validation, 267 client-vendor-matched-pair data were collected. To avoid potential imbalance caused by the bilateral perspective, an exploratory approach, all-possible-subsets-regression method was adopted. The results reveal that the vendor’s competence is the most significant factor in outsourcing success, but interestingly, the fit between vendor competence and the client’s IT capability is the second most important. The client’s IT capability also has a positive impact on outsourcing success but with the smallest explanation power

Identification of the optimal hiit protocol for fatigue resistance in adolescent athletes: a randomized controlled trial

The combat sports athletes developed great gains in both muscular function and fatigue resistance by utilizing high-intensity interval training (HIIT). However, it has not been investigated fully whether different work-to-rest ratios of HIIT show the effectiveness on muscle function in adolescent athletes. The purpose of the study was to compare different work-to-rest ratios by applying different rest times in response to the identical work time during HIIT on muscle function in adolescent taekwondo athletes. Forty-seven adolescent male taekwondo athletes (mean age: 16.7±0.8 years) were randomly assigned to the control group (n=11) vs. three HIIT groups by work-to-rest ratios; (1) 1:2 [30s:60s] (n=12), (2) 1:4 [30s:120s] (n=12), and (3) 1:8 [30s:240s] (n=12). All groups completed 10 experimental sessions over four weeks, while the control group maintained their regular taekwondo training. Muscular functions were measured by assessing isokinetic muscle strength and endurance of the knee extensor and flexor. The participants performed three sets of twenty maximal extension and flexion contractions at 120°s-1 with a 1-min interval between the sets for fatigue resistance. Blood samples were collected to measure free-testosterone, cortisol, creatine kinase, and urea as stress-to-recovery indicators. A positive effect on improving muscle fatigue resistance was observed at the first set of assessments in the HIIT with 1:4 (Δ10.2%, p<.05) and 1:8 groups (Δ8.6%, p<.05). Additionally, the 1:4 group exhibited fatigue resistance improvement in the second set (Δ7.7%, p<.01) without any changes of stress-to-recovery indicators, while the other groups did not show any improvement. The 30s all-out work with 120s rest time, lasting over a brief 4-week period, improved participants’ fatigue resistance. A certain amount of rest time between high-intense movements is required to optimize muscle development in adolescent athletes compared with insufficient rest time

Thermoelectric properties of graphene incorporated thermoelectric materials

Thermoelectric materials, which can change the waste heat into the usable electricity, are interested in various field of applications such as vehicle, ship, power plane, and so on. To enhance the thermoelectric properties, high electrical conductivity, high Seebeck coefficient, and low thermal conductivity should be conducted, however, the trade-off relation between electronic property and thermal property in terms of carrier concentration could be the bottle-neck on the enhancement of thermoelectric properties of the materials. In this presentation, we discuss with the graphene incorporation in the conventional thermoelectric materials, which could lead to independently control electric and thermal properties