First-person Narration in Life of Pi

Life of Pi is the masterpiece of Canadian writer Yann Martel(1963- ). Since it was published, the book has been warmly received by the audience, and is on the list of the most popular world classics. Its huge success is closely connected with the unique narrative techniques Yann Martel employs. This paper tends to explore its homodiegetic first person narration. Specifically, the hero/narrator Pi in the intradiegetic level recalls the shipwreck he goes through many years later, in particular how he survives the accident; while a mask narrator in the extradiegetic level supplements and verifies intradiegetic narrative, and guides readers to make their own judgment and take proper ethical position. As a whole, inside Life of Pi there are two opposing tendencies: one is the realistic portrayal of the testing voyage after the shipwreck; the other is the apparent uncertainty as the telling of the story is constantly subverted and denarrated. Thus a tension is created, and the whole work has a fantastic and surreal coloring. These two opposing and contradictory tendencies, I believe, are related to Martel’s aesthetic ideas: the top priority for an artist is not the actuality of a story but the imagination and life within.

Spatiotemporal evolution and drivers of carbon inequalities in urban agglomeration:An MLD-IDA inequality indicator decomposition

Increasing countries are articulating ambitious goals of carbon neutrality. However, large inequalities in regional emissions within a country may hinder progress toward a carbon–neutral future, as the unequal distribution of reduction responsibilities among regions could impair just transition and exacerbate uneven development, which necessitates an in-depth understanding of the mechanism of multi-scale carbon inequalities within country, region, and city. Yet, the evolution of carbon inequalities within urban agglomerations and the differences between adjacent or distant urban agglomerations have not been well understood, especially in countries undergoing rapid urbanization. Using the data of 89 cities in China’s Yangtze River Economic Belt (YREB) during 2006–2021, this paper quantifies carbon emissions inequality (CEI) at different scales in a systematic regional-urban agglomeration-city hierarchical structure. Then, under the integrated mean logarithmic deviation-logarithmic mean Divisia index (MLD-LMDI) decomposition framework, multi-scale CEIs are perfectly decomposed into six interrelated drivers, i.e., industrial emission structure, energy emission intensity, industrial energy mix, energy intensity, industrial structure, and economic development. The results show that economic development, energy intensity, and industrial energy mix disparities are the main determinants accounting for CEIs at different scales. The decreasing CEI in YREB is mainly due to the changes in industrial structure and economic development, while the energy intensity effect partially hinders the mitigation of CEI. In the upper reaches of the YREB, the energy intensity effect accounts for over 94% growth of CEI during 2006–2021, while the decline in CEIs in middle and lower reaches is primarily caused by the effects of industrial energy mix and industrial structure, respectively. Further spatial decomposition analysis reveals more refined city-level heterogeneous effects and emphasizes the prioritized emission reduction direction for each city. This paper offers implications for reducing carbon inequality and insights into coordinated carbon emissions mitigation at the regional level for a carbon–neutral future

Piecewise pseudo almost periodic solutions of interval general BAM neural networks with mixed time-varying delays and impulsive perturbations

This paper is concerned with piecewise pseudo almost periodic solutions of a class of interval general BAM neural networks with mixed time-varying delays and impulsive perturbations. By adopting the exponential dichotomy of linear differential equations and the fixed point theory of contraction mapping. The sufficient conditions for the existence of piecewise pseudo almost periodic solutions of the interval general BAM neural networks with mixed time-varying delays and impulsive perturbations are obtained. By adopting differential inequality techniques and mathematical methods of induction, the global exponential stability for the piecewise pseudo almost periodic solutions of the interval general BAM neural networks with mixed time-varying delays and impulsive perturbations is discussed. An example is given to illustrate the effectiveness of the results obtained in the paper

Fast Green FCF Attenuates Lipopolysaccharide-Induced Depressive-Like Behavior and Downregulates TLR4/Myd88/NF-κB Signal Pathway in the Mouse Hippocampus

Depression is a common neuropsychiatric disorder and new anti-depressive treatments are still in urgent demand. Fast Green FCF, a safe biocompatible color additive, has been suggested to mitigate chronic pain. However, Fast green FCF’s effect on depression is unknown. We aimed to investigate Fast green FCF’s effect on lipopolysaccharide (LPS)-induced depressive-like behavior and the underlying mechanisms. Pretreatment of Fast green FCF (100 mg/kg, i.p. daily for 7 days) alleviated depressive-like behavior in LPS-treated mice. Fast green FCF suppressed the LPS-induced microglial and astrocyte activation in the hippocampus. Fast green FCF decreased the mRNA and protein levels of Toll-like receptor 4 (TLR4) and Myeloid differentiation primary response 88 (Myd88) and suppressed the phosphorylation of nuclear factor-κB (NF-κB) in the hippocampus of LPS-treated mice. Fast green FCF also downregulated hippocampal tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, but did not alter the level of the brain-derived neurotrophic factor (BDNF) in the hippocampus of LPS-treated mice. The molecular docking simulation predicts that Fast green FCF may interact with TLR4 and interrupt the formation of the TLR4-MD2 complex. In conclusion, the anti-depressive action of Fast green FCF in LPS-treated mice may involve the suppression of neuroinflammation and the downregulation of TLR4/Myd88/NF-κB signal pathway in mouse hippocampus. Our findings indicate the potential of Fast green FCF for controlling depressive symptoms

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis Through Regulating APC/C Activity

Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in development and tumorigenesis, we disrupted Sirt2 in mice. We demonstrated that SIRT2 regulates the anaphase-promoting complex/cyclosome activity through deacetylation of its coactivators, APC(CDH1) and CDC20. SIRT2 deficiency caused increased levels of mitotic regulators, including Aurora-A and -B that direct centrosome amplification, aneuploidy, and mitotic cell death. Sirt2-deficient mice develop gender-specific tumorigenesis, with females primarily developing mammary tumors, and males developing more hepatocellular carcinoma (HCC). Human breast cancers and HCC samples exhibited reduced SIRT2 levels compared with normal tissues. These data demonstrate that SIRT2 is a tumor suppressor through its role in regulating mitosis and genome integrity

A Central Consciousness at Work Beneath the Surface Artlessness: Narrative Strategies in “Tristram Shandy”

‘The Life and Opinions of Tristram Shandy, Gentleman’ (hereafter shortened to “Tristram Shandy”) is a unique novel written by British author Laurence Sterne in the eighteenth century. While Sterne’s contemporary readers may have conflicting viewpoints about the artistic value of “Tristram Shandy” because of its surface artlessness and chaos, readers today in the contexts of such twentieth-century critical theories as postmodernism, existentialism, and deconstruction, find it congenial and more intriguing. I argue that despite the apparent chaos of this novel, the author-narrator Tristram is a central consciousness that holds the whole work together. And I believe Sterne narrates his story in such a peculiar way in conformity to his own perception of the outside world. Specifically, this paper aims to explore the inventive narrative strategies employed in Sterne’s “Tristram Shandy” in the three aspects of narrative structure, time-shifting technique and self-conscious narrator. Amazingly, “Tristram Shandy” presents a wholly new notion of creative writing, one that goes beyond its time, and has unbreakable connection with twentieth-century literature