Peritumoral cystic meningioma

A case of 39 years old male is described who presented with headache, right-sided focal fits and decreased power in the right hand. CT scan brain showed a left fronto-parietal cystic lesion with centrolateral intramural nodule with homogenous enhancement. At surgery, the extra-axial lesion with cyst containing xanthochromic fluid had a well-defined capsule that could easily be separated from the peri-lesional cortical surface. The dural-based nodule with its cyst wall was resected in toto. The histopathology of mural nodule was reported as meningioma while the cyst wall histology revealed meningothelial cells

Volatility Linkages between Equity Markets of Pakistan, India, Singapore and Hong Kong: A GARCH BEKK Approach

The purpose of current study is to explore the volatility linkages between four Asian equity markets, which arePakistan (Karachi Stock Exchange), India (Bombay Stock Exchange), Hong Kong (Hang Sang Index) and Singapore (Strait Time Index). We estimate Multivariate GARCH BEKK model using weekly returns from January 2000 to August 2011.Direct evidences of linkages are found among all markets with respect to conditional mean returns and volatility.Own volatility spillover is found greater than cross volatility spillover in all emerging and developed economies.The insinuation of this study is that overseas investors may take advantage from the decrease of uncertainty by accumulating the stocks in the emerging markets to their investment portfolio

Investigating the Effect of Gradation, Temperature and Loading Duration on the Resilient Modulus of Asphalt Concrete

This research was carried out to assess the effect of aggregate skeleton, temperature variation, and loading duration on the resilient modulus of asphalt concrete mixtures. Two different gradation methods, i.e., the conventional method of gradation and the Bailey method of gradation, were adopted to design the aggregate skeleton. The effect of these gradation methods, with temperature and loading duration, on the resilient modulus of asphalt concrete has not been previously investigated. The Modified Marshall Test was used to determine optimum binder content against 4% air voids, and then volumetric and strength parameters were calculated against optimum binder content. For performance tests, specimens were prepared at optimum binder content using a Superpave gyratory compactor. An indirect tensile strength test on both types of mixtures was conducted, and a 20% value of indirect tensile strength was kept for peak load, whereas 10% was kept for seating load for conducting resilient modulus tests. The tests were conducted at 100 and 300 ms duration loads under two different temperatures, i.e., 25 oC and 40 oC. The results declared that aggregate skeleton, temperature, and loading duration have a prominent effect on the resilient modulus of asphalt concrete mixtures. Bailey gradation mixtures disclosed higher resilient modulus values than conventional gradation mixtures. Higher values of resilient modulus were observed for both gradation mixtures at low temperatures and under small duration loads than at high temperatures and large duration loads. The results of the two-way factorial design also confirmed the above findings. Doi: 10.28991/CEJ-2022-08-02-07 Full Text: PD

Effect of Gender on the Outcome of Acute Coronary Syndrome in Type 2 Diabetes Mellitus

OBJECTIVES To determine the frequency of acute coronary syndrome presentations among diabetic patients and in-hospital outcomes based on gender variance. METHODOLOGY This observational cross-sectional study was conducted at the cardiology department of the Pakistan Institute of Medical Sciences, Islamabad. 106 consecutive diabetic patients with acute coronary syndrome were enrolled. Patients were assessed for in-hospital outcomes like congestive heart failure, recurrent angina, and mortality. The outcomes were evaluated based on gender. The Chi-Square test was used for significant differences keeping the P value < 0.05.  RESULTSThe mean age of the patients was 57.75±8.16 years. Males were 57 (53.8%), and females were 49 (46.2%). Congestive heart failure, re-angina, and mortality were significant in both genders yielding a P value of <0.05. CONCLUSION Diabetes is an important predictor of acute coronary syndrome. The complications related to congestive heart failure and mortality are more prevalent in males than females

FRACTURE ANALYSIS AND RESERVOIR POTENTIAL OF EXPOSED EOCENE SUCCESSIONS ALONG KOHAT-ORAKZAI TRANSACT KHYBER PAKHTUNKHWA, NW PAKISTAN

The present research work is primarily focusing on fracture analysis of exposed Eocene limestone to estimate the reservoir potential by Monte Carlo Techniques. The methodology implemented is the scanline method which were used for fracture data collections during field work. Three stations were selected for fracture data which consists of 30 scanlines for comprehensive petrophysical properties i.e., fracture density, porosity, and permeability. The computer software was used for interpretation of fracture orientation data. The interpretation demonstrates two prevailing fracture sets existing in the study area which have average NE and NW strike. However, the correlation between their properties is documented based on charts. The consequence specifies that the correlation between density and porosity is variable although the density and permeability is linear. The qualitative classification was based on NFR system analyzed for the reservoir potential which shows very defective correlation whereas fractures provide flexible assistance and does not offer significant additional porosity and permeability. Thus, it occurs from type 4 to type 3 NFR system of classification

Comparison of Peritonsillar Injection of Lignocaine-Adrenaline and Normal Saline (placebo) Before Tonsillectomy in Terms of Mean PerOperative Blood Loss

Objective: To compare peritonsillar injection of lignocaine-adrenaline and normal saline (placebo) before tonsillectomy in terms of mean peroperative blood loss. Patients and Methods: This randomized controlled trial was carried out at Department of ENT Head and Neck Surgery, Pakistan Institute of Medical Sciences, Islamabad study in six months’ time. A total of 60 patients were included in the study, their demographics data and clinical findings were noted. Subjects were randomly divide in two groups (30 in each group). Group A received injection of lignocaine-adrenaline in peritonsillar region and group B received normal saline (placebo), prior to tonsillectomy. Blood loss in both groups during surgery was measured by means of gauze pieces used and suction bottle. Results: Both groups were assessed for intraoperative blood loss. Despite marked reduction of blood loss in group A, the difference in two groups was not statistically significance (p-value=0.213) after applying independent sample t test. Post-stratification student t test showed a statistical significance in the age groups 15 – 20 years (p-value=0.018). Conclusion: Our study concludes that the group injected with lignocaine-adrenaline in the peritonsillar area had a marked reduction in peroperative blood loss as compared to the group that was injected with normal saline (placebo)

Exploring the antibacterial and dermatitis-mitigating properties of chicken egg white-synthesized zinc oxide nano whiskers

IntroductionZinc oxide nanoparticles (ZnO-NPs) have garnered considerable interest in biomedical research primarily owing to their prospective therapeutic implications in combatting pathogenic diseases and microbial infections. The primary objective of this study was to examine the biosynthesis of zinc oxide nanowhiskers (ZnO-NWs) using chicken egg white (albumin) as a bio-template. Furthermore, this study aimed to explore the potential biomedical applications of ZnO NWs in the context of infectious diseases.MethodsThe NWs synthesized through biological processes were observed using electron microscopy, which allowed for detailed examination of their characteristics. The results of these investigations indicated that the NWs exhibited a size distribution ranging from approximately 10 to 100 nm. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) mapping analyses successfully corroborated the size, dimensions, and presence of biological constituents during their formation. In this study, XTT assay and confocal imaging were employed to provide evidence of the efficacy of ZnO-NWs in the eradication of bacterial biofilms. The target bacterial strains were Staphylococcus aureus and Escherichia coli. Furthermore, we sought to address pertinent concerns regarding the biocompatibility of the ZnO-NWs. This was achieved through comprehensive evaluation of the absence of cytotoxicity in normal HEK-293T and erythrocytes.ResultsThe findings of this investigation unequivocally confirmed the biocompatibility of the ZnO-NWs. The biosynthesized ZnO-NWs demonstrated a noteworthy capacity to mitigate the dermatitis-induced consequences induced by Staphylococcus aureus in murine models after a therapeutic intervention lasting for one week.DiscussionThis study presents a comprehensive examination of the biosynthesis of zinc oxide nanowhiskers (ZnO-NWs) derived from chicken egg whites. These findings highlight the considerable potential of biosynthesized ZnO-NWs as a viable option for the development of therapeutic agents targeting infectious diseases. The antibacterial efficacy of ZnO-NWs against both susceptible and antibiotic-resistant bacterial strains, as well as their ability to eradicate biofilms, suggests their promising role in combating infectious diseases. Furthermore, the confirmed biocompatibility of ZnO-NWs opens avenues for their safe use in biomedical applications. Overall, this research underscores the therapeutic promise of ZnO-NWs and their potential significance in future biomedical advancements

Standred interferon therapy and its Response rates in Chronic HCV Patients in District Mardan, Khyber Pakhtunkhwa

To eradicate the Hepatitis C Virus from the bodies of the infected individuals Interferon and Ribavirin based therapy is used. HCV is highly prevalent in District Mardan Khyber Pakhtunkhwa that is why it is important to determine the response of standard interferon based therapy in Chronic HCV patients of this region. A total of 215 patients were selected for interferon based therapy. The patients were selected from three different Tehsil of District Mardan. After confirmation of active HCV infection by q-PCR, standard interferon with Ribavirin was given to patients for 6 months. After completion of therapy, end of treatment virologic response (ETR) was calculated. After completion of the 6 months long therapy, the results obtained were as. Out of total 215 patients, 168 (78.13%) were negative for HCV RNA and showing end of treatment response (ETR) while 47 (21.86%) were positive for HCV RNA and did not show ETR. In Tehsil Mardan, out of 102 patients who had completed therapy, 76 patients (74.51%) showed ETR and 26 (25.49%) did not show the ETR. In Tehsil Kattlang, we found that out of total 51 patients who had taken 6 months therapy, 41 (80.39%) were negative for HCV RNA and 10 (19.61%) were resistant to therapy while in Tehsil Tkhatbhai, out of 62, 50 (80.64%) were negative and 12 (19.35%) were positive. The above discussion shows that antiviral therapy against HCV infection in chronic HCV patients of District Mardan KPK province is 78.13%. The high response rate may be due to the prevalence of genotypes 2 and 3

Reverse Object Oriented Design Methodology (R-OODM)

Software design plays a vital role in better understanding of the software system and its architecture. It also provides help throughout the software development life cycle and afterwards in its maintenance as well. Web applications have been emerging enormously and subjected to continuous changes due to high competition in the market. But unfortunately, most of the web applications are implemented without producing any formal design documentation for its subsequent maintenance and evolution. Therefore, the maintenance of these applications becomes a challenging problem as the complexity of the web application grows. The reverse engineering techniques has been used to support effective web application maintenance. We have proposed a Reverse Object Oriented Design Methodology (R-OODM) that extracts the design of web application using design phase models of OODM [1][15], based upon water fall model. A tool has also been developed for implementation of this reverse object oriented design methodology