2 research outputs found
Palladium-Catalyzed/Norbornene-Mediated <i>ortho</i>-Amination/<i>N</i>‑Tosylhydrazone Insertion Reaction: An Approach to the Synthesis of <i>ortho</i>-Aminated Vinylarenes
<i>ortho</i>-Aminated vinylarene derivatives were obtained
via a reaction of aryl iodides, <i>N</i>-benzoyloxyamines,
and <i>N</i>-tosylhydrazones. This approach involves a palladium-catalyzed,
norbornene-mediated <i>ortho</i>-amination/<i>N</i>-tosylhydrazone insertion reaction. In this transformation, one C–N
bond and one C–C bond are formed and an amine group is introduced
at the <i>ortho</i> position successfully
Iodine-Promoted Radical Cyclization in Water: A Selective Reaction of 1,6-Enynes with Sulfonyl Hydrazides
An iodine-promoted one-pot radical
cyclization reaction of 1,6-enynes
with sulfonyl hydrazides to provide five-membered and hexatomic ring
sulfonylated products under the same conditions is established. This
reaction proceeded smoothly in water and gave the corresponding products
by using I<sub>2</sub>/TBHP instead of expensive and toxic catalysts
with C–S and C–I bond formed in one step. This method
also allowed easy access to significant functional sulfones for potential
applications in medicinal and organic chemistry