Design and Evaluation a Knowledge Management System by Using Mathematical Model of Knowledge Transfer

Abstract. Based on our experiences, we have proposed a mathematical model for knowledge transfer in order to make knowledge management mechanism or system take root in the organization and to obtain guidelines to make it work. We are developing a know-how sharing system designed based on the insight obtained from the proposed model. We derived and applied the two ideas as design guidelines based on the analysis using the proposed model: one is mutual reviewing to increase the sense of participation, and another is establishment of the criteria to evaluate the background information about the knowledge to be shared. In this paper, we explain the proposed mathematical model and the system design based on the model. And we describe the evaluation on the prototype system. It shows that the mathematical model could derive guidelines to make the KM system work well

Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-211The nucleotide sequence reported herein has been deposited in the DDBJ, EMBL and GenBank databanks under the accession number AB034697.

AbstractA mouse cDNA that encodes a DNA-binding protein was identified by yeast two-hybrid screening, using activating transcription factor-2 (ATF-2) as the bait. The protein contained a bZIP (basic amino acid-leucine zipper region) domain and its amino acid sequence was almost identical to that of rat Jun dimerization protein 2 (JDP2). Mouse JDP2 interacted with ATF-2 both in vitro and in vivo via its bZIP domain. It was encoded by a single gene and various transcripts were expressed in all tested tissues of adult mice, as well as in embryos, albeit at different levels in various tissues. Furthermore, mouse JDP2 bound to the cAMP-response element (CRE) as a homodimer or as a heterodimer with ATF-2, and repressed CRE-dependent transcription that was mediated by ATF-2. JDP2 was identified as a novel repressor protein that affects ATF-2-mediated transcription