6 research outputs found

    Source process with heterogeneous rupture velocity for the 2011 Tohoku-Oki earthquake based on 1-Hz GPS data

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    Additional file 2: Table S1. Velocity structure used for Green’s functions

    Interaction of the solid Earth and the Antarctic ice sheet

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    第6回極域科学シンポジウム分野横断セッション:[IG] 全球環境変動を駆動する南大洋・南極氷床11月17日(火) 国立極地研究所 2階 大会議

    Entry to Chiral 1,1,2,3-Tetrasubstituted Arylcyclopropanes by Pd(II)-Catalyzed Arylation via Directing Group-Mediated C(sp<sup>3</sup>)‑H Activation

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    Here we report the construction of highly functionalized chiral 1,1,2,3-tetrasubstituted arylcyclopropanes of medicinal chemical importance using Pd­(II)-catalyzed arylation via directing group-mediated C­(sp<sup>3</sup>)-H activation. The key aspect for the effective arylation was control of the substrate conformation based on the characteristic steric and stereoelectronic features of cyclopropane by manipulating the protecting group at the hydroxyl. The arylation with good functional group tolerance is pivotal as the first entry to chiral 1,1,2,3-tetrasubstituted arylcyclopropanes with wide variety of aryl groups, including heteroaryl groups
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