6 research outputs found
Source process with heterogeneous rupture velocity for the 2011 Tohoku-Oki earthquake based on 1-Hz GPS data
Additional file 2: Table S1. Velocity structure used for Greenâs functions
Interaction of the solid Earth and the Antarctic ice sheet
第6回極域科学シンポジウム分野横断セッション:[IG] 全球環境変動を駆動する南大洋・南極氷床11月17日(火) 国立極地研究所 2階 大会議
Entry to Chiral 1,1,2,3-Tetrasubstituted Arylcyclopropanes by Pd(II)-Catalyzed Arylation via Directing Group-Mediated C(sp<sup>3</sup>)‑H Activation
Here
we report the construction of highly functionalized chiral
1,1,2,3-tetrasubstituted arylcyclopropanes of medicinal chemical importance
using Pd(II)-catalyzed arylation via directing group-mediated C(sp<sup>3</sup>)-H activation. The key aspect for the effective arylation
was control of the substrate conformation based on the characteristic
steric and stereoelectronic features of cyclopropane by manipulating
the protecting group at the hydroxyl. The arylation with good functional
group tolerance is pivotal as the first entry to chiral 1,1,2,3-tetrasubstituted
arylcyclopropanes with wide variety of aryl groups, including heteroaryl
groups