Infestasi Fasciola SP Pada Sapi Bali Dengan Sistem Pemeliharaan Yang Berbeda Di Desa Tanjung Rambutan Kecamatan Kampar

The purpose of the research was to identify the infestation of Fasciola sp on Bali cows in the different management systems. The research was done on June up to July 2007 at Tanjung Rambutan village, Kampar and BPPV Regional 0, Buldt Tinggi.Feces of 60 Bali cows from Tanjung Rambutan village were collected. The qualification of the cows are(1) the age should be more than 1.5 years old, (2) female and (3) free from wonn drugs. The 60 cows used in the research consist of 50 cows which were cared extensively and 10 cows intensively. The samples of feces were collected from the rectum, and examined for Fasciola sp eggs using the sedimentation test (Uji End4p). The data was analyzed using Chi Square method.The results of the research indicated that infestation of Fasciola sp on Bali cows were lower in the intensively farming than extensively. The laboratory test showed that 92% (46 samples) of Ball Cows which were cared extensively, infested by Fasciola sp eggs and 8% (4 samples) of them were negative. From 10 samples of Bali cows which were, 1 sample (10%) positively infected by theJasciola sp and 9 samples (90%) were negative

Mutu Susu Segar Di Upt Ruminansia Besar Dinas Peternakan Kabupaten Kampar Provinsi Riau

Milk as liquid food has a high nutrient content like protein, fat, vitamin, mineral and other substances that needed human body. Total production of fresh milk in UPT Ruminansia Besar Dinas Peternakan in KamparRegency is about 5 -6 liter per day. However, there isn\u27t information about the quality of fresh milk yet. The objective of this research was to determine the quality of fresh milk in terms of nutritional value, pH, sensory properties (taste, aroma and colour) and mastitis test. Results of the research showed that the nutrient content of fresh milk was 92,35 % .±. 0,11 moisture, 1,6 % .±. 0,37 fat, 3,87 % .±. 0,99 crude protein, 0,91 %± 0,01 ash, pH value was 6,85 .±.0,Q4. Sensory evaluation from 15 untrained panelist showed that normal taste (3,9), milky aroma (3,8) and white in colour (3,4). Subclinic mastitis test indicated that the total of leukocyte in fresh milk was in trace (I) criteria. Most of these parameters matched to the Indonesian quality standard SNI 01-3141-1998 about quality standard of fresh milk except fat

TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression.

Background & Aims: Cholangiocarcinoma (CCA) is a cancer of the hepatic bile ducts that is rarely resectable and is associated with poor prognosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is known to signal via its receptor fibroblast growth factor-inducible 14 (Fn14) and induce cholangiocyte and myofibroblast proliferation in liver injury. We aimed to characterise its role in CCA. Methods: The expression of the TWEAK ligand and Fn14 receptor was assessed immunohistochemically and by bulk RNA and single cell transcriptomics of human liver tissue. Spatiotemporal dynamics of pathway regulation were comprehensively analysed in rat and mouse models of thioacetamide (TAA)-mediated CCA. Flow cytometry, qPCR and proteomic analyses of CCA cell lines and conditioned medium experiments with primary macrophages were performed to evaluate the downstream functions of TWEAK/Fn14. In vivo pathway manipulation was assessed via TWEAK overexpression in NICD/AKT-induced CCA or genetic Fn14 knockout during TAA-mediated carcinogenesis. Results: Our data reveal TWEAK and Fn14 overexpression in multiple human CCA cohorts, and Fn14 upregulation in early TAA-induced carcinogenesis. TWEAK regulated the secretion of factors from CC-SW-1 and SNU-1079 CCA cells, inducing polarisation of proinflammatory CD206+ macrophages. Pharmacological blocking of the TWEAK downstream target chemokine monocyte chemoattractant protein 1 (MCP-1 or CCL2) significantly reduced CCA xenograft growth, while TWEAK overexpression drove cancer-associated fibroblast proliferation and collagen deposition in the tumour niche. Genetic Fn14 ablation significantly reduced inflammatory, fibrogenic and ductular responses during carcinogenic TAA-mediated injury. Conclusion: These novel data provide evidence for the action of TWEAK/Fn14 on macrophage recruitment and phenotype, and cancer-associated fibroblast proliferation in CCA. Targeting TWEAK/Fn14 and its downstream signals may provide a means to inhibit CCA niche development and tumour growth. Lay summary: Cholangiocarcinoma is an aggressive, chemotherapy-resistant liver cancer. Interactions between tumour cells and cells that form a supportive environment for the tumour to grow are a source of this aggressiveness and resistance to chemotherapy. Herein, we describe interactions between tumour cells and their supportive environment via a chemical messenger, TWEAK and its receptor Fn14. TWEAK/Fn14 alters the recruitment and type of immune cells in tumours, increases the growth of cancer-associated fibroblasts in the tumour environment, and is a potential target to reduce tumour formation

HIV-1 Drug Resistance Emergence among Breastfeeding Infants Born to HIV-Infected Mothers during a Single-Arm Trial of Triple-Antiretroviral Prophylaxis for Prevention of Mother-To-Child Transmission: A Secondary Analysis

Analysis of a substudy of the Kisumu breastfeeding trial by Clement Zeh and colleagues reveals the emergence of HIV drug resistance in HIV-positive infants born to HIV-infected mothers treated with antiretroviral drugs

Copas jonias y tipos relacionados

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Les céramiques archaïques du sanctuaire Carien de Labraunda. Vue d’ensemble

Grâce à l’étroite et amicale collaboration avec le Professeur Gösta Säflund il nous est possible de présenter un bref aperçu des céramiques archaïques du sanctuaire Carien de Labraunda. Il s’agit de documents qui ont été recueillis au cours des fouilles suédoises qui ont eu lieu sur le site entre 1949 et 1953. Ces fouilles ont permis de découvrir le plus ancien bâtiment de culte de ce sanctuaire de Zeus des Armées, les Propylées et des « terrasses ». Les traces d’incendie qui ont été reconnue..

Note sur la nécropole languedocienne de St. Julien, Pézenas (Hérault) et sur un vase ossuaire, stamnoïde, de la première moitié du VIe s. de cette nécropole

La basse vallée de l’Hérault au VIe s. était caractérisée non seulement par la présence des premiers navigateurs grecs d’Agde (cf. J. J. Jully, Les importations attiques dans la Néapolis d’Ampurias du VIe s. au IVe s., Revue belge de philologie et d’histoire, LIV, 1976, 1, p. 25-51, notamment p. 25 pour Agde et la basse vallée de l’Hérault) mais aussi par des habitats indigènes. Agde, troisième cité phocéenne du bassin occidental de la Méditerranée et située à mi-chemin de Marseille et d’Empo..