Antiplasmodial Activities of Homogentisic Acid Derivative Protein Kinase Inhibitors Isolated from a Vanuatu Marine Sponge Pseudoceratina sp.

As part of our search for new antimalarial drugs in South Pacific marine sponges, we have looked for inhibitors of Pfnek-1, a specific protein kinase of Plasmodium falciparum. On the basis of promising activity in a preliminary screening, the ethanolic crude extract of a new species of Pseudoceratina collected in Vanuatu was selected for further investigation. A bioassay-guided fractionation led to the isolation of a derivative of homogentisic acid [methyl (2,4-dibromo-3,6-dihydroxyphenyl)acetate, 4a] which inhibited Pfnek-1 with an IC50 around 1.8 μM. This product was moderately active in vitro against a FcB1 P. falciparum strain (IC50 = 12 μM). From the same sponge, we isolated three known compounds [11,19-dideoxyfistularin-3 (1), 11-deoxyfistularin-3 (2) and dibromo-verongiaquinol (3)] which were inactive against Pfnek-1. Synthesis and biological evaluation of some derivatives of 4a are reported

La Voz de Michoacán y los que no pueden oír: cambios discursivos en torno a las personas sordas morelianas en un diario local (1948 - 2014)

This paper examines how the newspaper La Voz de Michoacán has changed the way it refers to a sector that has been little analyzed by Mexican historiography: the deaf. The role of the press, in dissemination and modification of people’s opinion and perspective about this community, is highlighted through analyzing documents related to deaf people, and contextualizing these manuscripts into processes as rehabilitative medical model implementation, subsequently emphasizing human rights and non-discrimination to hearing-impaired people in MoreliaCet article examine comment le journal La Voz de Michoacán a changé la manière de faire référence à un secteur peu analysé par l’historiographie mexicaine : les sourds. Se souligne le rôle de la presse, pour répandre et modifier les points de vue et les perspectives des gens sur ce collectif, à travers l’analyse des documents concernant les sourds et leur contextualisation dans processus comme la mise en œuvre du modèle médical de rétablissement, ainsi que l’emphase sur les droits de l’homme et la non-discrimination aux personnes avec handicap auditif à MoreliaEste artículo examina los cambios en las formas en que el diario La Voz de Michoacán se refiere a un sector poco abordado por la historiografía mexicana: los sordos. A través de analizar las notas relacionadas con ellos y contextualizándolas en procesos como la implementación del modelo médico rehabilitatorio, el posterior énfasis en los derechos humanos y la no discriminación a las personas con discapacidad auditiva en Morelia, se destaca el papel de la prensa como vehículo para difundir y modificar las opiniones y perspectivas sobre ese colectiv

Haciendo “hablar” a una historia muda. Surgimiento y consolidación de la comunidad sorda de Morelia

Resumen: Este trabajo describe y analiza el nacimiento y desarrollo de la Comunidad Sorda de Morelia, subrayando los rasgos que la caracterizaron y algunos de los acontecimientos más relevantes de su pasado. Asimismo, mediante una breve revisión de la historia de uno de los grupos de sordos mejor estudiados y probablemente más influyente en México, el de los estudiantes de la Escuela Nacional de Sordomudos en la Ciudad de México, se muestran las similitudes y los contrastes entre este colectivo y el moreliano.Abstract: This paper describes and analyzes the origin and development of Morelia’s deaf community, emphasizing the features that typified it and some of the most outstanding events from its past. Also, some similarities and contrasts are drawn between this community and groups at the National School for Deaf-Mute People in Mexico City through a brief review of the latter’s histor

Palos de ciego, la Escuela Nacional de Ciegos y Sordomudos: historia del fracaso de un proyecto anacrónico (1928-1937)

Doctorado en HistoriaUniversidad Nacional Autónoma de México. Programa de Posgrado en Histori

Quitando el velo de la oscuridad: la Escuela Nacional de Ciegos (Ciudad de México, 1870 a 1928)

Maestría en HistoriaUniversidad Nacional Autónoma de México. Programa de Posgrado en Histori

Le centenaire de Fustel de Coulanges

Jullian Camille, Glotz Gustave, Pfister Christian. Le centenaire de Fustel de Coulanges. In: Revue internationale de l'enseignement, tome 84,1930. pp. 188-203

Le centenaire de Fustel de Coulanges

Jullian Camille, Glotz Gustave, Pfister Christian. Le centenaire de Fustel de Coulanges. In: Revue internationale de l'enseignement, tome 84,1930. pp. 188-203

Clostridium difficile contamination of health care workers' hands and its potential contribution to the spread of infection: Review of the literature

International audienc

Clostridium difficile contamination of health care workers' hands and its potential contribution to the spread of infection: Review of the literature

International audienc

NMR and molecular fluorescence spectroscopic study of the structure and thermodynamic parameters of EGCG/ B-cyclodextrin inclusion complexes with potential antioxidant activity

Artículo de publicación ISIThe present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like b-cyclodextrin (bCD), heptakis(2,6 di-O-methyl)-b-cyclodextrin (DMbCD), and hydroxypropyl-b-cyclodextrin (HPbCD) in aqueous solution. These inclusion complexes previously demonstrated improvements in the antioxidant activity respect to free EGCG. The structural evidence obtained by 2D-ROESY and selective 1D-ROESY experiments was rationalized by autodock studies and indicates that all the complexes have similar inclusion geometries, but the difference resides on the exposition degree of the antioxidant rings of EGCG, such as pyrogallol and galloyl groups. The thermodynamic study allowed estimating that the inclusion process is entalpically driven for the derivatized cyclodextrins complexes and entropically driven for bCD complexes due to the predominance of hydrophobic interactions with EGCG.This work was supported by CONICYT Project 24091025 and FONDECYT Project 11080038. Christian Folch-Cano gratefully acknowledges the contribution of CONICYT-CHILE for a Ph.D. fellowship. J. Guerrero gratefully acknowledges the contribution of MECESUP-0007 for an NMR spectrometer