BMC Womens Health

BACKGROUND: The French national cancer institute (INCa) conducted a series of studies to assist decision-making in view of the implementation of organised cervical cancer screening that will be launched in 2018. The programme will concern all women aged 25-65 and targeted interventions will be developed for underscreened populations. This is an evolution from an equality-based approach to a step-by-step strategy of equity aiming to tackle health cancer inequalities that are avoidable and represents unfair differences. Here we present the work of the expert-group in ethics drafted by INCa to review the ethical issues prior to the programme implementation. DISCUSSION: We discuss the value of such a strategy and presents reflections with regard to issues of stigmatization, respect for individual freedom and autonomy. Indeed, the balance has to be found between the search for beneficence and the potential occurrence of perverse effects, which should be considered with particular attention. CONCLUSION: Moving toward an equity-oriented policy under a strategy of proportionate universalism faces a number of challenges, thus an overview of ethics and social sciences must be an integral part of the process

Criblage virtuel (les essais in silico)

PARIS-BIUP (751062107) / SudocSudocFranceF

Stimulating effects of two plant growth-promoting bacteria, Enterobacter ludwigii Ez-185-17 and Raoultella terrigena Ez-555-6, on flax culture

2nd International Conference on Applied Sciences (ICAS), Ton Duc Thang Univ, Ho Chi Minh City, VIETNAM, MAY 24-25, 2018International audienceTwo bacteria, Enterobacter ludwigii Ez-185-17 and Raoultella terrigena Ez-555-6, isolated from root nodules of Medicago lupulina from the Chernobyl exclusion zone, were identified in a previous study and shown not to disturb plant growth. The main goal of this work is to elucidate the relationships between these bacteria and flax, in particular whether they display activities such as plant growth promoting bacteria (PGPB) properties or modulation hairy root development. In order to better understand their role in plants, some known PGPB properties were determined in comparison with several control bacteria. The influence of these bacteria on Linum usitatissimum growth under hydroponic conditions was also investigated. Our study shows that both bacteria belong to PGPB since they were able to increase considerably the root surface area of flax, especially Raoultella terrigena Ez-555-6. Significant IAA production and phosphate solubilization of Enterobacter ludwigii Ez-185-17 were highlighted, which enabled these biochemical PGPB properties to be correlated with their effects on flax growth. However, Raoultella terrigena Ez-555-6 did not express high biochemical activities, suggesting that other PGPB abilities should be studied in order to establish the link with flax growth improvement

Les filières de production. Nouvelles analyses au prisme de la bioéconomie

International audienceThe notion of a “value chain”, developed by the French school of industrial economics in the second half of the 20th century, is currently enjoying a revival – the fragmentation of economic activities is being called into question, interest in sustainable development is growing, and scientific and technical progress is opening up opportunities for the emergence of value chains rooted in local areas. This special issue of Technologie et Innovation analyzes the revival of value chains from a bioeconomic perspective, the bioeconomy being a field of activity based on the valorization of biomass. After presenting the founding works, this introductory article analyzes the revival of work in the specific context of the bioeconomy, and develops the economic, environmental and political stakes involved in the development of biosourced value chains. The final section presents the articles included in this issue.La notion de filière, développée par l’école française d’économie industrielle dans la seconde partie du 20e siècle, connait aujourd’hui un renouveau dans le contexte de la remise en cause de la fragmentation des activités économiques, de l’intérêt porté au développement durable et des progrès scientifiques et techniques qui ouvrent des opportunités pour l’émergence de filières ancrées sur les territoires. Ce numéro spécial de la revue Technologie et Innovation analyse ce renouveau des filières de production au prisme de la bioéconomie qui représente un champ d’activité s’appuyant sur la valorisation de la biomasse. Après avoir présenté les travaux fondateurs, cet article introductif analyse le renouveau des travaux dans le contexte particulier de la bioéconomie et développe les enjeux économiques, environnementaux et politiques du développement des filières de production biosourcées. La dernière partie présente les articles insérés dans ce numéro

A Review of <i>Pistacia lentiscus</i> Polyphenols: Chemical Diversity and Pharmacological Activities

Pistacia lentiscus (lentisk) is a plant species of the Anacardiaceae family. It is a medicinal plant that grows wild in the Mediterranean region. This review aims to update the existing knowledge regarding P. lentiscus polyphenols by consulting references dated from 1996 to 2022. The data are organized and analyzed as follows: (i) to show the chemical diversity of phenolic products from P. lentiscus; (ii) to summarize the variability in phenolic composition and quantity; this could be attributed to plant origin, environmental conditions, phenological stage, and the polarity of the extraction solvents; (iii) to present the pharmacological properties in agreement with the traditional uses of this plant; and (iv) to demonstrate the correlation between the chemical profile and the pharmacological effect. Various compositions were observed, including phenolic acids, flavonoid glycosides, anthocyanins, catechins, and their derivatives. The biological and therapeutic potentials of lentisk extracts have been evaluated in terms of antioxidant, antimicrobial, and anti-inflammatory activities. Most of these activities are related to the phenolic composition of this plant. The content of this review will undoubtedly contribute to the choice of techniques for isolating the different bioactive molecules contained in the P. lentiscus. It is also of significance for the potential development of a micro-industrial sector based on the valorization of lentisk polyphenols

A Review of Pistacia lentiscus Polyphenols: Chemical Diversity and Pharmacological Activities

Pistacia lentiscus (lentisk) is a plant species of the Anacardiaceae family. It is a medicinal plant that grows wild in the Mediterranean region. This review aims to update the existing knowledge regarding P. lentiscus polyphenols by consulting references dated from 1996 to 2022. The data are organized and analyzed as follows: (i) to show the chemical diversity of phenolic products from P. lentiscus; (ii) to summarize the variability in phenolic composition and quantity; this could be attributed to plant origin, environmental conditions, phenological stage, and the polarity of the extraction solvents; (iii) to present the pharmacological properties in agreement with the traditional uses of this plant; and (iv) to demonstrate the correlation between the chemical profile and the pharmacological effect. Various compositions were observed, including phenolic acids, flavonoid glycosides, anthocyanins, catechins, and their derivatives. The biological and therapeutic potentials of lentisk extracts have been evaluated in terms of antioxidant, antimicrobial, and anti-inflammatory activities. Most of these activities are related to the phenolic composition of this plant. The content of this review will undoubtedly contribute to the choice of techniques for isolating the different bioactive molecules contained in the P. lentiscus. It is also of significance for the potential development of a micro-industrial sector based on the valorization of lentisk polyphenols

Structural features and bioremediation activity of an exopolysaccharide produced by a strain of Enterobacter ludwigii isolated in the Chernobyl exclusion zone

International audienceThe bacterium Enterobacter ludwigii Ez-185-17, member of the family Enterobacteriaceae, was isolated from the root nodules of plants harvested in the nuclear power region of Chernobyl. Under batch culture conditions, the bacteria produce a high-molecular-mass exopolysaccharide (EPS). After purification, the structure of this EPS was determined using a combinatory approach including monosaccharide composition (GC-FID, HPAEC-PAD) and branching structure determination (GC-MS), as well as 1D/2D NMR ((1)H, (13)C) and ESI-MS (HR, MS/MS) studies of oligosaccharides obtained from mild acid hydrolysis. The EPS was found to be a charged hexasaccharide with a repeating unit composed of d-galactose, d-glucose, l-fucose, d-glucuronic acid (2:1:2:1) and substituted with acyl and pyruvyl groups. The metal-binding properties of the exopolysaccharide were then investigated, and the results seem to indicate that the EPS decreased Cd sequestration in flax seeds