Remediación ambiental de contaminantes orgánicos persistentes mediante el uso de nanomateriales biofabricados para su adsorción: Revisión sistemática

El presente estudio tuvo como objetivo general definir los aspectos más relevantes de la remediación ambiental de contaminantes orgánicos persistentes mediante el uso de nanomateriales biofabricados para su adsorción; Utilizando como metodología un tipo de investigación básica, el diseño narrativo agrega 26 artículos al estudio. Los resultados obtenidos mostraron que los contaminantes más degradados fueron colorantes con un 58%, pesticidas con un 19%, contaminantes vegetales con un 15%, combustibles con un 4% y contaminantes farmacéuticos con un 1%. Porque la industria textil es una de las prácticas que mayor aprovechamiento hace del agua, contaminando así los cuerpos de agua. Las funciones de los nanomateriales biofabricados contra contaminantes orgánicos persistentes presentan función fotocatalítica; Esto se debe a que la fotocatálisis que utiliza fotocatalizadores como nanomateriales biofabricados se considera una técnica esperanzadora para biodegradar y controlar la contaminación de diversos recursos como el agua, el suelo y el aire. Finalment

Design, Construction, and Quality Control Guidelines for Stress-Laminated Timber Bridge Decks

DTFH61-90-00067This publication is part of a collection of three booklets of the study "Education and Technology Transfer", under the Timber Bridge Research Program. The other two booklets are: FHWA-RD-92-044 - Corrosion Protection of Steel Hardware Used in Modern Timber Bridges; and FHWA-RD-93-024 - Timber Substructures for Bridge Applications.Under the U.S. National Timber Bridge Initiative Program, sponsored by Congress in 1989 and administered by the United States Department of Agriculture, Forest Service, approximately 130 modern timber bridges are currently in service in 41 participating States. Most of these bridges use stress-laminating technology. Considerable research on stress-laminating technology has been completed in the USA and has provided design, construction, and inspection guidelines for timber bridge decks. Guidelines for the design of stress-laminated timber decks have been published by AASHTO, but they do not provide comprehensive information on materials, construction, and inspection. Therefore, this document presents: (1) background information on timber bridge materials and their quality control; (2) a comprehensive step-by-step design procedure based on the 1991 AASHTO Guide Specification; and (3) guidelines for construction, field monitoring, inspection, and maintenance procedures. Potential fabrication problems are discussed, and an inspection checklist is included

Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies

Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. The increasingly recognized relevance of epigenetic changes in cancer immunology prompted us to determine the impact of the DNA methylation profiles of CART19 cells on the clinical course. Methods: We recruited 114 patients with B-cell malignancies, comprising 77 patients with acute lymphoblastic leukemia and 37 patients with non-Hodgkin lymphoma who were treated with CART19 cells. Using a comprehensive DNA methylation microarray, we determined the epigenomic changes that occur in the patient T cells upon transduction of the CAR vector. The effects of the identified DNA methylation sites on clinical response, cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, event-free survival, and overall survival were assessed. All statistical tests were 2-sided. Results: We identified 984 genomic sites with differential DNA methylation between CAR-untransduced and CAR-transduced T cells before infusion into the patient. Eighteen of these distinct epigenetic loci were associated with complete response (CR), adjusting by multiple testing. Using the sites linked to CR, an epigenetic signature, referred to hereafter as the EPICART signature, was established in the initial discovery cohort (n = 79), which was associated with CR (Fisher exact test, P < .001) and enhanced event-free survival (hazard ratio [HR] = 0.36; 95% confidence interval [CI] = 0.19 to 0.70; P = .002; log-rank P = .003) and overall survival (HR = 0.45; 95% CI = 0.20 to 0.99; P = .047; log-rank P = .04;). Most important, the EPICART profile maintained its clinical course predictive value in the validation cohort (n = 35), where it was associated with CR (Fisher exact test, P < .001) and enhanced overall survival (HR = 0.31; 95% CI = 0.11 to 0.84; P = .02; log-rank P = .02). Conclusions: We show that the DNA methylation landscape of patient CART19 cells influences the efficacy of the cellular immunotherapy treatment in patients with B-cell malignancy.Supported by CERCA Programme/Generalitat de Catalunya, Health Department PERIS #SLT/002/16/00374, AGAUR-project #2017SGR1080; MCI/AEI/ERDF project #RTI2018-094049-B-I00; ERC EPIPHARM; Cellex Foundation; “la Caixa” Foundation (LCF/PR/GN18/51140001 and LCF/PR/GN18/50310007), RF-2016–02364388, Accelerator Award—Cancer Research UK/AIRC—INCAR Associazione Italiana Ricerca per la Ricerca sul Cancro (AIRC) Project 5 × 1000 no. 9962, AIRC IG 2018 id. 21724, AIRC MFAG id. 21769 and id. 20450; MIUR (Grant PRIN 2017); and RCR-2019–23669115

On the Linear Viscoelasticity Of thin-walled Laminated Composite Beams

An analytical model to predict the linear viscoelastic behavior of thin-walled laminated fiber-reinforced plastic (FRP) composite beams is presented. Using the correspondence principle, this new model integrates micro/macro-mechanics of composites and mechanics of thinwalled laminated beams to perform beam analyses in the Laplace or Carson domains. The analytical expressions for beam relaxation coefficients are obtained. Using a collocation method, the flexural creep behavior of beams in the time domain is numerically solved. Predictions by the present model are compared favorably with experimental data for glass fiber-reinforced plasti