Temperature profile of ex-vivo organs during radio frequency thermal ablation by fiber Bragg gratings.

We report on the integration of fiber optic sensors with commercial medical instrumentation for temperature monitoring during radio frequency ablation for tumor treatment. A suitable configuration with five fiber Bragg grating sensors bonded to a bipolar radio frequency (RF) probe has been developed to monitor the area under treatment. A series of experiments were conducted on ex-vivo animal kidney and liver and the results confirm that we were able to make a multipoint measurement and to develop a real-time temperature profile of the area, with a temperature resolution of 0.1°C and a spatial resolution of 5 mm during a series of different and consecutive RF discharges

Temperature monitoring during thermal ablation on ex-vivo organs by Fiber Bragg gratings

In this paper we report on the application of Fiber Bragg gratings (FBGs) for temperature monitoring during radiofrequency ablation (RFA) for tumor treatment. A proper configuration with several FBG sensors deployed close to the region reached by RF discharges has been developed to monitor the necrotized area. Our ex-vivo experiments on animal kidney and liver confirm that we were able to monitor the temperature with a resolution of 0.1 °C during a series of different and consecutive RF discharges with the laparoscopic bipolar radiofrequency device Habib 4x

Measurements of temperature during thermal ablation treatments on ex vivo liver tissue using fiber Bragg grating sensors

In this work, we propose the use of fiber Bragg grating (FBG) sensor arrays for real-time temperature monitoring during RadioFrequency Thermal Ablation (RFTA) tumor treatment. Real-time temperature monitoring of RF-treatment to the tumors lesion of an organ could prove to be highly beneficial for intra-operative surgical planning and subsequently ensure a successful outcome of a thermo-ablation procedure. An adequate configuration was designed in order to create a thermal multipoint map. In particular, the RF probe of a commercial medical device was properly packaged with FBG sensors. In order to discern the treatment areas as accurately as possible, a second 3.5 cm long array, consisting of several FBGs was also employed. The experiments were conducted on ex vivo animal liver tissues and results confirm that we were successfully able to conduct a multipoint measurement and to distinguish between different and consecutive RF discharges with a temperature resolution of 0.1 °C and a minimum spatial resolution of 5mm

Real-Time temperature monitoring during radiofrequency treatments on ex-vivo animal model by fiber Bragg grating sensors

Fiber Bragg Grating (FBG) sensors applied to bio-medical procedures such as surgery and rehabilitation are a valid alternative to traditional sensing techniques due to their unique characteristics. Herein we propose the use of FBG sensor arrays for accurate real-Time temperature measurements during multi-step RadioFrequency Ablation (RFA) based thermal tumor treatment. Real-Time temperature monitoring in the RF-Applied region represents a valid feedback for the success of the thermo-Ablation procedure. In order to create a thermal multi-point map around the tumor area to be treated, a proper sensing configuration was developed. In particular, the RF probe of a commercial medical instrumentation, has been equipped with properly packaged FBGs sensors. Moreover, in order to discriminate the treatment areas to be ablated as precisely as possible, a second array 3.5 cm long, made by several FBGs was used. The results of the temperature measurements during the RFA experiments conducted on ex-vivo animal liver and kidney tissues are presented herein. The proposed FBGs based solution has proven to be capable of distinguish different and consecutive discharges and for each of them, to measure the temperature profile with a resolution of 0.1 °C and a minimum spatial resolution of 5mm. Based upon our experiments, it is possible to confirm that the temperature decreases with distance from a RF peak ablation, in accordance with RF theory. The proposed solution promises to be very useful for the surgeon because a real-Time temperature feedback allows for the adaptation of RFA parameters during surgery and better delineates the area under treatment

Differential in vivo urodynamic measurement in a single thin catheter based on two optical fiber pressure sensors

Urodynamic analysis is the predominant method for evaluating dysfunctions in the lower urinary tract. The exam measures the pressure during the filling and voiding process of the bladder and is mainly interested in the contraction of the bladder muscles. The data arising out of these pressure measurements enables the urologist to arrive at a precise diagnosis and prescribe an adequate treatment. A technique based on two optical fiber pressure and temperature sensors with a resolution of better than 0.1  cm H2O (∼10  Pa), a stability better than 1  cm H2O/hour, and a diameter of 0.2 mm in a miniature catheter with a diameter of only 5 Fr (1.67 mm), was used. This technique was tested in vivo on four patients with a real-time urodynamic measurement system. The optical system presented showed a very good correlation to two commercially available medical reference sensors. Furthermore, the optical urodynamic system demonstrated a higher dynamic and better sensitivity to detect small obstructions than both pre-existing medical systems currently in use in the urodynamic field

Temperature Monitoring during Radio Frequency Thermal Ablation Treatment on Ex Vivo perfused organ by Fiber Bragg Grating Sensors

In this work, we report on the integration of fiber Bragg gratings sensors in a commercial radio frequency probe for real-time temperature monitoring during thermal ablation of biological tissues. The experiments were conducted on ex-vivo pig liver and bovine kidney tissues and the results confirm that the proposed setup is able to conduct a multi-point real-time temperature monitoring during the RF discharges with a temperature resolution of 0.1 °C and a minimum spatial resolution of 1 mm. During these experiments the blood perfusion was implemented by injecting water at a temperature of 37 °C inside the organ under examination. This solution aimed at simulating the Radio Frequency Thermal Ablation (RFTA) treatments made in clinical practice

Temperature Monitoring during Radio Frequency Thermal Ablation Treatment on Ex Vivo perfused organ by Fiber Bragg Grating Sensors

In this work, we report on the integration of fiber Bragg gratings sensors in a commercial radio frequency probe for real-time temperature monitoring during thermal ablation of biological tissues. The experiments were conducted on ex-vivo pig liver and bovine kidney tissues and the results confirm that the proposed setup is able to conduct a multi-point real-time temperature monitoring during the RF discharges with a temperature resolution of 0.1 °C and a minimum spatial resolution of 1 mm. During these experiments the blood perfusion was implemented by injecting water at a temperature of 37 °C inside the organ under examination. This solution aimed at simulating the Radio Frequency Thermal Ablation (RFTA) treatments made in clinical practice

Multidimensional thermal mapping during radiofrequency ablation treatments with minimally invasive fiber optic sensors

Temperature mapping is a key asset in supporting the clinician during thermal ablation (TA) treatment of tumors without adding additional risk to the TA procedure. Herein we report our experiments on multidimensional thermal mapping during radio frequency (RF) thermal ablation treatments of an ex-vivo animal organ. The temperature was monitored using several arrays of fiber Bragg gratings properly positioned around the RF applicator. The results show the effectiveness of our proposed method at assessing the TA probe depth and demonstrating how the insertion depth directly influences the maximum temperature and the treated area of the radio frequency ablation

Differential in vivo urodynamic measurement in a single thin catheter based on two optical fiber pressure sensors

Urodynamic analysis is the predominant method for evaluating dysfunctions in the lower urinary tract. Theexammeasures thepressure duringthefilling andvoidingprocess ofthe bladderandismainlyinterested in the contraction of the bladder muscles. The data arising out of these pressure measurements enables the urologist to arrive at a precise diagnosis and prescribe an adequate treatment. A technique based on two optical fiber pressure and temperature sensors with a resolution of better than 0.1 cmH2O(∼10 Pa), a stability better than 1 cmH2O∕hour, and a diameter of 0.2 mm in a miniature catheter with a diameter of only 5 Fr (1.67 mm), was used. This technique was tested in vivo on four patients with a real-time urodynamic measurement system. The optical system presented showed a very good correlation to two commercially available medical reference sensors.Furthermore,theopticalurodynamicsystemdemonstratedahigherdynamicandbettersensitivitytodetect small obstructions than both pre-existing medical systems currently in use in the urodynamic field