Producción y comercialización de bebidas saludables a base de frutas y suplementos naturales

The present business plan is based on the creation of Natural Healthy. A company that produces natural juices, based on fruits and organic vitamin supplements. At this moment the national government is promoting through the productive matrix natural food and beverage, therefore promoting unprocessed food and beverages in the country. In addition, you see an increasing world trend, which is the consumption of natural and nutritious drinks...El presente plan de negocios se basa en la creación de Natural Healthy. Una empresa productora de jugos naturales, a base de frutas y suplementos vitamínicos orgánicos. En este momento el gobierno nacional está impulsando a través de la matriz productiva la industria de alimentos y bebidas naturales, poco procesadas. Además, se ve una tendencia mundial en auge, que es el consumo de bebidas naturales y nutritivas..

Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I

Glutaric acidemia type I (GA-I) is an inherited disorder of lysine and tryptophan metabolism presenting with striatal lesions anatomically and symptomatically similar to Huntington disease. Affected children commonly suffer acute brain injury in the context of a catabolic state associated with nonspecific illness. The mechanisms underlying injury and age-dependent susceptibility have been unknown, and lack of a diagnostic marker heralding brain injury has impeded intervention efforts. Using a mouse model of GA-I, we show that pathologic events began in the neuronal compartment while enhanced lysine accumulation in the immature brain allowed increased glutaric acid production resulting in age-dependent injury. Glutamate and GABA depletion correlated with brain glutaric acid accumulation and could be monitored in vivo by proton nuclear magnetic resonance (1H NMR) spectroscopy as a diagnostic marker. Blocking brain lysine uptake reduced glutaric acid levels and brain injury. These findings provide what we believe are new monitoring and treatment strategies that may translate for use in human GA-I

Prevalence of Cervical Cancer Screening Among Women in Fishing Communities of Entebbe Municipality, Wakiso District. A Cross-sectional study.

Background: Cervical cancer disease in Uganda remains the leading causes of deaths among cancer patients, responsible for about 4,607 deaths annually. Despite the numerous modern treatment options and prevention strategies, cervical cancer screening prevalence remains undefined especially in the fishing communities and yet women living in fishing communities are core interest groups for cervical cancer due to their relatively higher risk of HIV and HPV infections. Methodology: A cross-sectional study employing a quantitative approach was performed, purposive sampling following a household survey was conducted. Structured interviews and questionnaires were administered to collect data from June 2021 to August 2021. Data were analyzed in SPSS version 25 using the log-binomial model. Results: prevalence of cervical cancer screening among women in fishing communities of Entebbe municipality, Wakiso district remains as low as 23.2%, mainly unsatisfactory among the married women (aPR = 0.232 [0.13 - 0.43], p < 0.001) and, Catholics (aPR = 0.050 [0.01 - 0.18], p < 0.001).  At the same time, higher cervical cancer screening prevalence was observed among employed women (aPR= 2.81 [1.48 - 5.33], p = 0.002), those who had prior recommendation from healthcare workers (aPR = 1.25 [0.09 - 0.65], p = 0.004), and those who perceived that cervical cancer is a curse from God (cPR = 2.800 [CI = 1.798 - 4.36], P = 0.000). Conclusion:  Cervical cancer screening is low among women in fishing communities of Entebbe municipality; only 2 in every 10 women have ever been screened for cervical cancer in their lifetime, while less than 1 in 10 had to follow-up of screening. Recommendation: Behavior change communication preferably using the intrapersonal channel on issues related to cervical cancer screening should be adopted in the fishing communities urgently if we are to elevate the uptake of this secondary prevention measure for cervical cancer

Mesenchymal Factor Bone Morphogenetic Protein 4 Restricts Ductal Budding and Branching Morphogenesis in the Developing Prostate

AbstractThe budding of the urogenital sinus epithelium into the surrounding mesenchyme signals the onset of prostate morphogenesis. The epithelial and mesenchymal factors that regulate ductal budding and the ensuing process of ductal growth and branching are not fully known. We provide evidence that bone morphogenetic protein 4 (BMP4) is a mesenchymal factor that regulates ductal morphogenesis. The Bmp4 gene was most highly expressed in the male urogenital sinus from embryonic day 14 through birth, a period marked by formation of main prostatic ducts and initiation of ductal branching. From an initial wide distribution throughout the prostatic anlage of the urogenital sinus, Bmp4 expression became progressively restricted to the mesenchyme immediately surrounding the nascent prostatic ducts and branches. Exogenous BMP4 inhibited epithelial cell proliferation and exhibited a dose-dependent inhibition of ductal budding in urogenital sinus tissues cultured in vitro. Adult Bmp4 haploinsufficient mice exhibited an increased number of duct tips in both the ventral prostate and coagulating gland. Taken together, our data indicate that BMP4 is a urogenital sinus mesenchymal factor that restricts prostate ductal budding and branching morphogenesis

Sentiment analysis with genetically evolved Gaussian kernels

Sentiment analysis consists of evaluating opinions or statements based on text analysis. Among the methods used to estimate the degree to which a text expresses a certain sentiment are those based on Gaussian Processes. However, traditional Gaussian Processes methods use a prede- fined kernels with hyperparameters that can be tuned but whose structure can not be adapted. In this paper, we propose the application of Genetic Programming for the evolution of Gaussian Process kernels that are more precise for sentiment analysis. We use use a very flexible representation of kernels combined with a multi-objective approach that considers si- multaneously two quality metrics and the computational time required to evaluate those kernels. Our results show that the algorithm can outper- form Gaussian Processes with traditional kernels for some of the sentiment analysis tasks considered

INTRAPERSONAL FACTORS ASSOCIATED WITH CERVICAL CANCER SCREENING AMONG WOMEN IN FISHING COMMUNITIES OF ENTEBBE MUNICIPALITY, WAKISO DISTRICT. A CROSS-SECTIONAL STUDY.

Background The chances of developing cervical cancer in Uganda continue to rise especially in the fishing communities due to the relatively higher prevalence of inter-related personal risk factors. This study aimed to examine the Intrapersonal Factors Associated with Cervical Cancer Screening Among Women in Fishing Communities of Entebbe Municipality, Wakiso District. Methodology A descriptive cross-sectional survey study was conducted among women in the fishing communities of Entebbe-Municipality Wakiso district in Central Uganda and utilized quantitative methods of data collection. Data were collected using a structured questionnaire with multiple-response questions. Data were analyzed using SPSS version 25, univariate, bivariate, and multivariate analysis were performed at 5% level significance. Results Of the 293 respondents that were interviewed, only 23.2% of women had ever been screened for cervical cancer. More than three-quarters of them knew that cervical cancer is not curable 234(79.9%). 150(51.2%) women mentioned that the age at the start of screening for cervical cancer in Uganda is 18 years and had 46% less prevalence of cervical cancer screening (cPR = 0.54 [0.33 - 0.90], p = 0.020). Among the perception attributes Cervical cancer screening prevalence was twice as high among women who agreed that cervical cancer is a curse from God (cPR = 2.43 [CI = 1.49 - 3.97], P = 0.000) compared to those who disagreed. Conclusion The intrapersonal factors associated with cervical cancer screening among women in the fishing communities of Entebbe municipality were mainly; marital status, employment status, knowledge of age at the start of the screening, and perceptions of the relevance of screening. Recommendation Communication and education should focus on awareness creation about the fact that even in a marriage where not much risky sexual behavior may be present, the risk of HPV infection remains apparent, for instance from sexually transmitted infections within the couple

Spatial patterns of anthrax outbreaks and cases among livestock in Lesotho, 2005–2016

BACKGROUND: Although anthrax occurs globally, the burden of the disease remains particularly high in Africa. Furthermore, the disease anthrax has significant public health and economic implications. However, sufficient attention has not been given to the geographic distribution of anthrax outbreaks and cases in Lesotho. Therefore, this study investigates the spatial patterns of anthrax outbreaks and cases among livestock in Lesotho from 2005 to 2016. METHODS: A cross-sectional study design was adopted to realise the objectives of this study using retrospective data of anthrax outbreaks and cases recorded by the Department of Livestock Services (DLS) between 2005 and 2016. Anthrax outbreaks were geo-coded at village level and aggregated at district level. Proportions and 95% CI of anthrax outbreaks and cases by village and district were calculated. Cartographic maps displaying the distribution of anthrax outbreaks and cases at village and district level were constructed. RESULTS: A total of 38 outbreaks were reported over the study period, and they were clustered in the Lowlands districts of Lesotho. Most outbreaks (52.6%, 20/38) in livestock were reported in the Maseru district. The Leribe district reported the lowest proportions of outbreaks (5.3%, 2/38) and cases (0.6%, 3/526). At the village level, 18% (7/38) of outbreaks were in Maseru Urban, followed by Ratau (16%, 6/38) and Mofoka (13%, 5/38). The Maseru district reported the highest (1.3%, 369/29,070) proportion of cases followed by Mafeteng (0.9%, 73/8530). The village with the most cases was Kolo (10.5%, 21/200), followed by Thaba-Chitja (7.7%, 33/430). CONCLUSION: Anthrax outbreaks and cases exclusively occur in the Lowlands districts of Lesotho, with villages such as Mahobong, Pitseng, Kolo, and Thaba-Chitja having a higher risk of anthrax disease. Findings of the present study have serious public health implications in light of the fact that between 2003 and 2008 Lesotho’s main abattoir was closed; hence, most of the meat in Lesotho was imported and/or sourced from the informal slaughter facilities. Much larger studies are needed to further investigate factors contributing to spatial disparities in anthrax outbreaks and cases observed in this study. Findings of the present study can be used to guide the formulation of a policy on prevention and control of anthrax in Lesotho.http://www.mdpi.com/journal/ijerphpm2021Paraclinical Science

Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions: Modulation of Inflammatory Gene Networks

The study aimed to identify mechanosensitive pathways and gene networks that are stimulated by elevated cyclic pressure in aortic valve interstitial cells (VICs) and lead to detrimental tissue remodeling and/or pathogenesis. Porcine aortic valve leaflets were exposed to cyclic pressures of 80 or 120 mmHg, corresponding to diastolic transvalvular pressure in normal and hypertensive conditions, respectively. Linear, two-cycle amplification of total RNA, followed by microarray was performed for transcriptome analysis (with qRT-PCR validation). A combination of systems biology modeling and pathway analysis identified novel genes and molecular mechanisms underlying the biological response of VICs to elevated pressure. 56 gene transcripts related to inflammatory response mechanisms were differentially expressed. TNF-α, IL-1α, and IL-1β were key cytokines identified from the gene network model. Also of interest was the discovery that pentraxin 3 (PTX3) was significantly upregulated under elevated pressure conditions (41-fold change). In conclusion, a gene network model showing differentially expressed inflammatory genes and their interactions in VICs exposed to elevated pressure has been developed. This system overview has detected key molecules that could be targeted for pharmacotherapy of aortic stenosis in hypertensive patients