Using Construal Level Theory to Promote HPV Vaccine Uptake Among College Males

College males’ uptake of human papilloma virus (HPV) vaccination is low. Prior research indicates perceived susceptibility to HPV among college males is also low. Construal level theory may offer a framework to alter perceived susceptibility and intention to vaccinate, but little research has examined this potential. Construal level theory provides foundational elements including that low construal level of perceptions is associated with more proximal psychological distance (hypothetical, social, temporal and spatial). Research indicates a disparity in college males’ susceptibility estimates which suggests high hypothetical distance. A reduction in hypothetical distance should be indicated by a measured increase in perceived susceptibility. Additionally, if construal level primed by messages is consistently associated with stage of change, then movement through stages of change might be promoted by influencing construal level such that perceived hypothetical distance is reduced. Additionally, the impact of interactivity on construal level and associated outcomes was explored. This study included two online experiments. In the first, a message was presented in components based on construal level dimensions. The second experiment was a 2x2, including high construal interactive message, low construal interactive message, high construal non-interactive message, and low construal non-interactive message conditions. The outcome variables of interest in both cases are hypothetical distance, barrier construal, stage of change and intention to vaccinate for HPV. Construal level dimensions did not offer explanatory value to the relationship between barriers and stage of change, a temporal measure of vaccination intention. However, the results indicate that perceptions of messages as lower construal are associated with increases in perceived susceptibility and intention to vaccinate for HPV. Perceived interactivity was associated with reduced social distance and increase in intention to vaccinate. This study suggests that construal level theory may be useful in the formative evaluations for HPV-related campaigns targeting males. This study also supports the addition of interactive elements to health campaigns, however the exact type of interactivity warrants further research. Limitations and directions for future research are discussed

A Solution Hiding in Plain Sight: Special Education and Better Outcomes for Students with Social, Emotional, And Behavioral Challenges

This Article will contribute to the ongoing dialogue about special education and the IDEA in two ways. First, it will describe patterns that have emerged from our work with individual children and families that shed light on how common IDEA implementation failures increase the risk of poor outcomes for students with social, emotional and behavioral challenges. Critiques of the law and proposals to amend it should be grounded in an understanding of exactly how and why it is falling short of meeting its promise to these children. Our hope is that mapping the common implementation failures we have seen in our cases will advance this understanding - at least with respect to the particular population of students for whom we advocate - and will help guide the development of public policy. Second, this Article will assert that fixing these common implementation failures is a critical reform and a worthwhile investment of public time, money and attention. While proposing specific legislative remedies or strategies is beyond the scope of this Article, we will suggest some priorities for reform that appear warranted based on our work

Partnering with pediatric patients and families in high reliability to identify and reduce preventable safety events

Frameworks for designing highly reliable behaviors and tools to reduce preventable harm are the result of the continued effort to improve patient safety in healthcare. Evidence shows that there has been limited research on engaging patients and families in the development of safety and reliability efforts to achieve zero harm. Our aim was to develop a tool that engages patients and families in an effort to reduce preventable harm in a pediatric academic medical center

Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review

Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. Results. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5–8%. Conclusions. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required

Alternatives for sustained disaster risk reduction

The daily media is filled with images of catastrophic events which seem increasingly frequent and violent In parallel there are a large range of scientific studies debates in the policy arena, and a growing number of international institutions focused on disaster reduction. But a paradox remains that despite advances in technology, disasters continue to increase, affecting many individuals in rich as well as poor countries

Midlife Women's Responses to a Hospital Sleep Challenge: Aging and Menopause Effects on Sleep Architecture

Objective: To distinguish aging from menopause effects on sleep architecture, we studied an episode of disturbed hospital sleep in asymptomatic midlife women during the follicular phase of an ovulatory cycle and three control groups differing by age or menopause status. Methods: Fifty-one studies were conducted in four groups of volunteers: young cycling (YC, 20-30 years, n = 14), older cycling (OC, 40-50 years, n = 15), ovariectomized receiving estrogen therapy (OVX, 40-50 years, n = 12), and spontaneously postmenopausal (PM, 40-50 years, n = 10). Subjects were admitted to the University Hospital General Clinical Research Center (GCRC) for a first-night sleep study conducted during a 24-hour, frequent blood sampling protocol. Results: Despite similar estrogen concentrations in the YC (28 ± 4 pg/ml) and OC (34 ± 6 pg/ml) groups, OC women had reduced sleep efficiency (79% ± 2%) vs. YC (87% ± 3%; p = 0.009). In the OVX and PM groups where estrogen concentrations were markedly different, sleep efficiency was also reduced vs. the YC group (OVX vs. YC, 79% ± 3% vs. 87% ± 3%, p = 0.05; PM vs. YC, 75% ± 3% vs. 87% ± 3%, p = 0.007). Wake time was longer in the three older groups (103 ± 10 minutes, 101 ± 12 minutes, 123 ± 12 minutes for OC, OVX, PM, respectively) vs. YC (63 ± 13 minutes, p < 0.05). The number of stage shifts was positively associated with advancing age (rho = 0.3, p < 0.03) but not with estrogen concentration. Conclusions: Aging-related sleep deficits in response to an experimental stressor occur in midlife women prior to menopause.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63173/1/154099904323016491.pd

Metal worker’s lung: spatial association with Mycobacterium avium

Background Outbreaks of hypersensitivity pneumonitis (HP) are not uncommon in workplaces where metal working fluid (MWF) is used to facilitate metal turning. Inhalation of microbe-contaminated MWF has been assumed to be the cause, but previous investigations have failed to establish a spatial relationship between a contaminated source and an outbreak. Objectives After an outbreak of five cases of HP in a UK factory, we carried out blinded, molecular-based microbiological investigation of MWF samples in order to identify potential links between specific microbial taxa and machines in the outbreak zone. Methods Custom-quantitative PCR assays, microscopy and phylogenetic analyses were performed on blinded MWF samples to quantify microbial burden and identify potential aetiological agents of HP in metal workers. Measurements and main results MWF from machines fed by a central sump, but not those with an isolated supply, was contaminated by mycobacteria. The factory sump and a single linked machine at the centre of the outbreak zone, known to be the workstation of the index cases, had very high levels of detectable organisms. Phylogenetic placement of mycobacterial taxonomic marker genes generated from these samples indicated that the contaminating organisms were closely related to Mycobacterium avium. Conclusions We describe, for the first time, a close spatial relationship between the abundance of a mycobacterium-like organism, most probably M. avium, and a localised outbreak of MWF-associated HP. The further development of sequence-based analytic techniques should assist in the prevention of this important occupational disease

10Kin1day: a bottom-up neuroimaging initiative

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain

Transradial approach for diagnostic cerebral angiograms in the elderly: a comparative observational study

Introduction: The transradial approach (TRA) reduces mortality, morbidity, access site complications, hospital cost, and length of stay while maximizing patient satisfaction. We aimed to assess the technical success and safety of TRA for elderly patients (aged ≥75 years). Methods: A retrospective chart review and comparative analysis was performed for elderly patients undergoing a diagnostic cerebral angiogram performed via TRA versus transfemoral approach (TFA). Also, a second comparative analysis was performed among the TRA cohort between elderly patients and their younger counterparts. Results: Comparative analysis in the elderly (TRA vs TFA) showed no significant differences for contrast dose per vessel, fluoroscopy time per vessel, procedure duration, conversion rate, and access site complications. Radiation exposure per vessel was significantly lower in the elderly TRA group. The second comparison (TRA in elderly vs TRA in the young) showed no significant differences for contrast dose per vessel, radiation exposure per vessel, procedure duration, access site complication, and conversation rate. A trend for prolonged fluoroscopy time per vessel was observed in the elderly TRA group. Conclusion/Discussion: TRA is a technically feasible and safe option for diagnostic neurointerventional procedures in the elderly. Our small elderly cohort was not powered enough to show a significant difference in terms of access site complications between TRA and TFA