Syndrome in question

Waardenburg syndrome is an inherited disease characterized by sensorineural hearing loss, pigmen-tation changes and minor facial malformations. It has four clinical variants. We report the case of a girl who, like her mother, was affected by this syndrome. The diagnosis was made after detection and treatment of deafness

Role of gut microbiota in infectious and inflammatory diseases

Thousands of microorganisms compose the human gut microbiota, fighting pathogens in infectious diseases and inhibiting or inducing inflammation in different immunological contexts. The gut microbiome is a dynamic and complex ecosystem that helps in the proliferation, growth, and differentiation of epithelial and immune cells to maintain intestinal homeostasis. Disorders that cause alteration of this microbiota lead to an imbalance in the host’s immune regulation. Growing evidence supports that the gut microbial community is associated with the development and progression of different infectious and inflammatory diseases. Therefore, understanding the interaction between intestinal microbiota and the modulation of the host’s immune system is fundamental to understanding the mechanisms involved in different pathologies, as well as for the search of new treatments. Here we review the main gut bacteria capable of impacting the immune response in different pathologies and we discuss the mechanisms by which this interaction between the immune system and the microbiota can alter disease outcomes

Role of gut microbiota in infectious and inflammatory diseases

Thousands of microorganisms compose the human gut microbiota, fighting pathogens in infectious diseases and inhibiting or inducing inflammation in different immunological contexts. The gut microbiome is a dynamic and complex ecosystem that helps in the proliferation, growth, and differentiation of epithelial and immune cells to maintain intestinal homeostasis. Disorders that cause alteration of this microbiota lead to an imbalance in the host’s immune regulation. Growing evidence supports that the gut microbial community is associated with the development and progression of different infectious and inflammatory diseases. Therefore, understanding the interaction between intestinal microbiota and the modulation of the host’s immune system is fundamental to understanding the mechanisms involved in different pathologies, as well as for the search of new treatments. Here we review the main gut bacteria capable of impacting the immune response in different pathologies and we discuss the mechanisms by which this interaction between the immune system and the microbiota can alter disease outcomes

Tratamento de psoríase ungueal com laser de corante pulsado

Introdução: A psoríase é uma doença inflamatória crônica com prevalência estimada em 2% da população mundial. As alterações ungueais estão presentes em cerca de 50% dos casos e chegam a acometer até 80% dos pacientes em algum momento da vida. Elas costumam ser resistentes aos tratamentos convencionais e possuir caráter recidivante. O laser de corante pulsado (LCP) tem surgido como alternativa terapêutica. Objetivos: Avaliar a eficácia do LCP na psoríase ungueal e o impacto do tratamento na qualidade de vida. Métodos: Para este estudo foram selecionados quatorze pacientes com diagnóstico de psoríase das unhas provenientes do ambulatório de Dermatologia do Hospital de Clínicas de Porto Alegre ou de clínicas privadas, tratados com aplicação do LCP com fluência de 6J/cm2 e duração de pulso de 0,45ms nas unhas acometidas em sessões mensais por três meses e uma nova visita, para seguimento, após 90 dias era realizada. A avaliação objetiva dos resultados foi realizada pelo índice de gravidade da psoríase ungueal (NAPSI) e avaliação subjetiva através de registro fotográfico das unhas acometidas na primeira e na terceira sessões e 90 dias após a última sessão. O índice de qualidade de vida para dermatologia (DLQI) foi respondido na primeira e 90 dias após a última sessão. Resultados: A mediana de melhora nas contagens do NAPSI total, do NAPSI do leito e do NAPSI da matiz ungueais foram, respectivamente, de 44,15% (P=0,002), 50% (P=0,033) e 65,1% (P=0,024). Os pacientes apresentaram também melhora significativa no DLQI após o tratamento, com mediana de 40%. Conclusões: O LCP pode ser considerado uma alternativa de tratamento para psoríase ungueal.Introduction: Psoriasis is a chronic inflammatory disease with an estimated prevalence of 2% of the world population. The nail changes are present in about 50% of cases and affect up to 80% of patients at some point in life. Nail psoriasis is often refractory to conventional treatments. Pulsed dye laser (PDL) has emerged as an alternative therapy. Objectives: To evaluate the efficacy of PDL in nail psoriasis and the impact of treatment on quality of life. Methods: For this study, were selected eleven patients diagnosed with nail psoriasis from the Dermatology clinic of the Hospital de Clínicas de Porto Alegre or private clinics. PDL was applied in affected nails with fluency of 6J/cm2 and pulse duration of 0,45ms in monthly sessions for three months. A follow-up visit after 90 days was done. The outcome assesment was made by the Nail Psoriasis Severity Index (NAPSI) and photographic records in the basement, in the third session and in the follow-up. The Dermatology Life Quality Index (DLQI) was answered in the baseline and in the follow-up. Results: The median improvement in the scores of the overall NAPSI, nail bed NAPSI and nail matrix NAPSI were respectively 44.15% (P = 0.002), 50% (P = 0.033) and 65.1% (P = 0.024). The patients also had significant improvement in DLQI after treatment with a median of 40%. Conclusions: PDL can be considered an alternative treatment for nail psoriasis

Nail psoriasis treated with pulsed dye laser

Nail changes are present in about 50% of psoriasis patients and tend to be refractory to conventional treatments. Pulsed dye laser has emerged as an alternative therapy. Our aim is to evaluate the efficacy of pulsed dye laser in nail psoriasis and the impact of treatment on quality of life. Fourteen patients were treated in monthly sessions for three months. The outcome assesment was made by the Nail Psoriasis Severity Index (NAPSI). The median improvement in the scores of the overall NAPSI, nail bed NAPSI, and nail matrix NAPSI were 44.2% (P = 0.002), 50% (P = 0.033) and 65.1% (P = 0.024), respectively