Product Service Systems : From Theory to Practice

This paper summarises the findings of the scoping phase of a pilot project, Exploring and developing ways to help people increase the useful life of products, through a leasing rather than ownership model of consumption. The focus of the research was into the provision of Baby and Nursery Equipment (B&NE). A primary objective was to explore attitudes towards this mode of consumption within both consumers and manufacturers. A secondary objective was to explore and demonstrate the feasibility of the business model(s) linked to modes of consumption through leasing rather than ownership. The project was funded by the UK Department of Environment, Food and Rural Affairs (DEFRA) and was part of their exploration of a Sustainable Lifestyle Framework, published in July 2011.The paper presents the initial stages of the research and does not attempt to give definitive conclusions. The key purpose of the paper is to outline the positive and negative findings highlighting both a possible structure and the barriers to a successful implementation of Product Service System Model of Consumption within this market sectorPeer reviewedFinal Accepted Versio

Application of Municipal Ordinances to Special Purpose Districts and Regulated Industries: A Home Rule Approach

This Article will examine the effect of municipal home rule on the doctrines that have developed to resolve one particular type of intergovernmental conflict-the attempt of a municipality to enforce its land use and construction standards and restrictions on facilities within its boundaries operated or regulated by other governmental units. First, we shall present models of the types of conflicts that have reached the courts. Second, we shall review existing case law to show that most courts have been guided in their decisions by a conceptualization of municipal governments as protectors of private, parochial interests-a conceptualization that is markedly at odds with modern home rule policies. Finally, we shall argue that home rule municipalities are in a unique position to resolve the competing public interests at stake in these conflicts and that their efforts to do so should be recognized and encouraged by the courts

Modelling three-dimensional trajectories by using BÉzier curves with application to hand motion

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72561/1/j.1467-9876.2007.00592.x.pd

The Association of Natural Elements and Trail Use by Adults

We used the System for Observing Play and Recreation in Communities to examine the association between variations in natural elements (ie, season, weather, and temperature) and adults' use of a rail-trail in South Carolina (2006-2009). Most (62%) of the 4,468 trail users observed were walkers; 38% were observed participating in vigorous physical activity. Adults were most often observed using the trail during the summer (32%), sunny weather (78%), and moderate temperatures (54%). When promoting trail use among adults, natural elements should be considered

Associations Between Sociodemographic Characteristics and Perceptions of the Built Environment With the Frequency, Type, and Duration of Physical Activity Among Trail Users

Introduction Rail trails are elements of the built environment that support the Task Force on Community Preventive Services\u27 recommendation to create, or enhance access to, places for physical activity (PA). The purpose of this study was to examine the associations between sociodemographic characteristics and perceptions of the built environment with the frequency, type, and duration of PA among users of an urban, paved rail trail segment. Methods Interviewers conducted intercept surveys with 431 rail trail users and analyzed data by using logistic regression to estimate odds ratios between sociodemographic characteristics and perceptions of the built environment on the frequency, type, and duration of PA performed on the trail. Results Adults who used the trail in the cool months, traveled to the trail by a motorized vehicle, used the trail with others, and had some graduate school education visited the trail less often. Younger adults, men, whites, and those with some graduate school education were more likely to engage in vigorous activities on the trail. Adults who traveled to the trail by a motorized vehicle spent more time engaged in PA on the trail. Conclusion Our results suggest that the most frequent users of a rail trail for PA are those who use the trail alone and travel to the trail by bicycle or on foot. Trails are an aspect of the built environment that supports active lifestyles, and future studies should evaluate different types of trails among more diverse populations and locations

Expression, Purification, Crystallization and Preliminary X-ray Studies of Histamine Dehydroganase from Nocardioides simplex

This is the publisher's version, also available electronically from http://scripts.iucr.org/cgi-bin/paper?S1744309108023336.Histamine dehydrogenase (HADH) from Nocardioides simplex catalyzes the oxidative deamination of histamine to produce imidazole acetaldehyde and an ammonium ion. HADH is functionally related to trimethylamine dehydrogenase (TMADH), but HADH has strict substrate specificity towards histamine. HADH is a homodimer, with each 76 kDa subunit containing two redox cofactors: a [4Fe-4S] cluster and an unusual covalently bound flavin mononucleotide, 6-S-cysteinyl-FMN. In order to understand the substrate specificity of HADH, it was sought to determine its structure by X-ray crystallography. This enzyme has been expressed recombinantly in Escherichia coli and successfully crystallized in two forms. Diffraction data were collected to 2.7 Å resolution at the SSRL synchrotron with 99.7% completeness. The crystals belonged to the orthorhombic space group P212121, with unit-cell parameters a = 101.14, b = 107.03, c = 153.35 Å

Reliability of a Brief Intercept Survey for Trail Use Behaviors

Purpose: This study assessed test-retest reliability of an interviewer-administered trail survey. Methods: An intercept survey was conducted with adults using 2 paved trails in Indiana and South Carolina (N = 295; mean age = 46.9 ± 18 y). The survey included items on frequency and duration of trail use for recreation and transportation, other patterns of trail use, and sociodemographic characteristics. Fiftyfive adults completed the survey twice (2–16 d apart; mean = 7.4 ± 2.6 d). Test-retest reliability was assessed with Spearman rank correlation coefficients, Kappa coefficients, and percent agreement. Results: Kappa coefficients and percent agreement for 9 categorical items ranged from 0.65 to 0.96 and from 64.0% to 98.2%, respectively. Among these items, the lowest Kappas were found for perceived safety (0.65) and reported duration of visits for recreational purposes (0.67). Spearman rank correlation coefficients for travel distance to and on the trail and frequency of trail use during the past 7 days and past 4 weeks ranged from 0.62 to 0.93. Conclusion: Though further assessments of this survey with different populations and types of trails may be warranted, its overall high reliability indicates it can be used by researchers and practitioners in its current form

Atm-Dependent Chk2 Activation Induced By Anticancer Agent, Irofulven

Irofulven (6-hydroxymethylacylfulvene, HMAF, MGI 114) is one of a new class of anticancer agents that are semisynthetic derivatives of the mushroom toxin illudin S. Preclinical studies and..

DNA replication initiation shapes the mutational landscape and expression of the human genome

The interplay between active biological processes and DNA repair is central to mutagenesis. Here, we show that the ubiquitous process of replication initiation is mutagenic, leaving a specific mutational footprint at thousands of early and efficient replication origins. The observed mutational pattern is consistent with two distinct mechanisms, reflecting the two-step process of origin activation, triggering the formation of DNA breaks at the center of origins and local error-prone DNA synthesis in their immediate vicinity. We demonstrate that these replication initiation–dependent mutational processes exert an influence on phenotypic diversity in humans that is disproportionate to the origins’ genomic size: By increasing mutational loads at gene promoters and splice junctions, the presence of an origin significantly influences both gene expression and mRNA isoform usage. Last, we show that mutagenesis at origins not only drives the evolution of origin sequences but also contributes to sculpting regulatory domains of the human genome