The Incorporation of Scientific Discourse in Yamamura Bochō's "Prismist" Poetry (1914-1916)

Yamamura Bochō (1884-1924) is mainly remembered as the author of "Seisanryōhari" (The Sacred Prism, 1915), a collection of "shi" (modern poetry in non-traditional forms) that represents the culmination of his experiments in diction and imagery. One of the most striking elements of his ‘prismist’ poetry is the presence of scientific language, coming from the domains of geology, botany, biology, and medicine. In this paper, I adopt a historical and textual perspective to attempt an analysis of the incorporation of scientific discourse in Bochō’s poetry. Particular emphasis is placed on the European and Japanese debate on the ‘new science’ and on the similarities to the treatment of this topic by Bochō and the discourses of the historical European avant-garde (especially Italian Futurism)

Liquidity spillovers in sovereign bond and CDS markets: an analysis of the Eurozone sovereign debt crisis

At the end of 2009, countries in the Eurozone (euro area) began to experience a sudden divergence of bond yields as the market perception of sovereign default risk increased. The theory of complete markets suggests that sovereign debt and credit default swap (CDS) credit spreads should track each other closely. In addition, liquidity risk should be priced into both instruments in such a way that buying exposure to the same default risk is identically priced. We use a time-varying vector autoregression framework to establish the credit and liquidity spread interactions over the 2009-2010 crisis period. We find substantial variation in the patterns of the transmission effect between maturities and across countries. Our major result is that, for several countries, including Greece, Ireland and Portugal the liquidity of the sovereign CDS market has a substantial time varying influence on sovereign bond credit spreads. This evidence is of particular importance in the current policy context. © 2011 Elsevier B.V

Credit derivatives and the default risk of large complex financial institutions

This paper proposes and implements a multivariate model of the coevolution of the first and second moments of two broad credit default swap indices and the equity prices of sixteen large complex financial institutions. We use this empirical model to build a bank default risk model, in the vein of the classic Merton-type, which utilises a multi-equation framework to model forward-looking measures of market and credit risk using the credit default swap (CDS) index market as a measure of the conditions of the global credit environment. In the first step, we estimate the dynamic correlations and volatilities describing the evolution of the CDS indices and the banks’ equity prices and then impute the implied assets and their volatilities conditional on the evolution and volatility of equity. In the second step, we show that there is a substantial ‘asset shortfall’ and that substantial capital injections and/or asset insurance are required to restore the stability of our sample institutions to an acceptable level following large shocks to the aggregate level of credit risk in financial markets

Microbiome manipulation with faecal microbiome transplantation as a therapeutic strategy in Clostridium difficile infection

Faecal microbiome transplantation (FMT) has generated huge recent interest as it presents a potential solution to a significant clinical problem—the increasing incidence of Clostridium difficile infection (CDI). In the short term, however, there remain many practical questions regarding its use, including the optimal selection of donors, material preparation and the mechanics of delivery. In the longer term, enhanced understanding of the mechanisms of action of FMT may potentiate novel therapies, such as targeted manipulation of the microbiome in CDI and beyond

Mattia Damiani (1705–1776), poet and scientist in eighteenth century Tuscany

Mattia Damiani da Volterra (1705–1776), “renowned Doctor,” was the author in 1754 of a collection of scientifi c poems, Le Muse Fisiche (The Physical Muses) on two subjects: Newtonian physics and the plurality of the worlds. Damiani’s interest in science was precocious, but even at that, it was superimposed on his studies in jurisprudence completed in Pisa in 1726. In 2003, Damiani’s lost text, De Hygrometris et eorum defectibus disputatio (Disputation about hygrometers and their defects), which was printed in 1726 in Pisa, was brought to light. It characterizes him as a young scientist who refl ected upon the properties and limits of laboratory instruments and on nascent aspects of climatology. In this Disputation, a delightful amalgamation of scientifi c and humanistic literature is pursued. A discussion of the properties and limits of contemporary hygrometers and a comparison of the Cartesian and Newtonian hypotheses about cloud formations are interspersed with quotations of verses on natural phenomena, mostly from poems of the classic age—a prelude to the author’s future involvement in writing scientifi c verses. The poetry of Damiani, which often shows a musicality comparable to that of the poet Giacomo Leopardi (1798–1837), deserves to be recognized and saved from oblivion. Especially remarkable is the implicit “multimedia” project of a union among science, poetry, theater, and music. The rediscovered Disputation about hygrometers opens a new window on the personages involved and on the evolution of meteorological concepts in Europe in the context of the then-new Galilean and Newtonian physics

Prophylactic and Therapeutic Breast Conservation in BRCA1/2 Mutation Carriers

Breast-conserving therapy (BCT) for sporadic breast cancer has been widely accepted by surgeons and patients alike. While BCT is associated with a higher risk of ipsilateral breast tumor recurrence (IBTR), it has not been shown to decrease overall survival (OS) in comparison with mastectomy. Many women with a BRCA1/2 mutation opt for mastectomy instead of breast-conserving measures at the time of a breast cancer diagnosis. In some cases, this is due to fear of aggressive disease, but to date, there have been no studies offering strong evidence that breast conservation should not be offered to these women. BRCA1/2-associated breast cancer has not been found to be more aggressive or resistant to treatment than comparable sporadic tumors, and no study has shown an actual survival advantage for mastectomy in appropriately treated affected mutation carriers. This paper reviews the available literature for breast conservation and surgical decision making in BRCA1/2 mutation carriers

An Untranslated cis-Element Regulates the Accumulation of Multiple C4 Enzymes in Gynandropsis gynandra Mesophyll Cells.

C4 photosynthesis is a complex phenotype that allows more efficient carbon capture than the ancestral C3 pathway. In leaves of C4 species, hundreds of transcripts increase in abundance compared with C3 relatives and become restricted to mesophyll (M) or bundle sheath (BS) cells. However, no mechanism has been reported that regulates the compartmentation of multiple enzymes in M or BS cells. We examined mechanisms regulating CARBONIC ANHYDRASE4 (CA4) in C4 Gynandropsis gynandra. Increased abundance is directed by both the promoter region and introns of the G. gynandra gene. A nine-nucleotide motif located in the 5' untranslated region (UTR) is required for preferential accumulation of GUS in M cells. This element is present and functional in three additional 5' UTRs and six 3' UTRs where it determines accumulation of two isoforms of CA and pyruvate,orthophosphate dikinase in M cells. Although the GgCA4 5' UTR is sufficient to direct GUS accumulation in M cells, transcripts encoding GUS are abundant in both M and BS. Mutating the GgCA4 5' UTR abolishes enrichment of protein in M cells without affecting transcript abundance. The work identifies a mechanism that directs cell-preferential accumulation of multiple enzymes required for C4 photosynthesis.We would like to thank the BBSRC for funding.This is the author accepted manuscript. The final version is available from the American Society of Plant Biologists via http://dx.doi.org/10.​1105/​tpc.​15.​0057

The range of peripapillary retinal nerve fibre layer and optic disc parameters, in children aged up to but not including 18 years of age who were born prematurely:protocol for a systematic review

Proposed list of data for extraction from full text articles. (DOCX 15 kb

Environmental controls of billfish species in the Indian Ocean and implications for their management and conservation

Abstract Background and aim Billfish are epipelagic marine predators facing increasing pressures such as overfishing and rising global temperatures. Overfishing is a major concern, as they are caught by industrial longline fishers targeting tuna. Billfish are targeted by multiple fishing sectors, which provides food, socio-economic and cultural benefits. To support effective billfish management and conservation, it is essential to understand their spatial distribution and the environmental factors that may influence it. Location The focus of this study is the Indian Ocean (IO), where there are gaps in understanding the interactions between fisheries and billfish distribution. Three of six billfish species are at risk from overfishing. Therefore, determining their distribution is crucial to their management and conservation. Methods Using Ocean Biogeographic Information System (OBIS) occurrence data, Indian Ocean Tuna Commission (IOTC) catch data, and environmental covariates, we applied species distribution models to investigate the spatial extent of the realized niches of six billfish species in the IO. We also determined the role and relative importance of environmental drivers. Moreover, we evaluated the association between species’ spatial distribution and the fishing effort distribution. Results We found niche partitioning and overlap among the six species identified spatial distribution, with higher species richness in the northern region of the IO and off the East coast of Africa. Temperature, mixed layer depth and salinity were identified as the most important predictors of species distribution, with moderately warm and stable environments preferred by most billfish species. Areas with high species richness and high fishing effort overlap were primarily found in the Areas Beyond National Jurisdiction (ABNJ). In contrast, areas with high species diversity richness and low fishing effort were found mainly in the Exclusive Economic Zone (EEZ). Main conclusion Spatial overlap between fishing effort and billfish projected distribution suggests inadvertent fishing pressure on billfish populations as they are caught together with targeted tuna. Spatial distribution transcends maritime zones, reinforcing a need to formulate effective management policies for marine areas beyond national jurisdictions