Investigation at Supersonic Speeds of the Variation with Reynolds Number and Mach Number of the Total, Base, and Skin-friction Drag of Seven Boattail Bodies of Revolution Designed for Minimum Wave Drag

Results are presented from an investigation of the variation with Reynolds number and Mach number of the total, base, and skin-friction drag of seven boattail bodies of revolution designed for minimum wave drag according to the theory of NACA-TN-2550. The tests covered a Reynolds number range from approximately 1.0 x 10(6) to 10.0 x 10(6) at Mach numbers of 1.62, 1.93, and 2.41 respectively

Investigation at supersonic speeds of the variation with Reynolds number and Mach number of the total, base, and skin-friction drag of seven boattail bodies of revolution designed for minimum wave drag

An investigation has been conducted in the Langley 9-inch supersonic tunnel to determine the effect of the variation with Reynolds number and Mach number of the total, base, and skin-friction drag at zero lift of seven boattail bodies of revolution designed for minimum wave drag according to NACA TN 2550. The tests covered a Reynolds number range from approximately 1.0 x 10(6) to 10.0 x 10(6) at Mach numbers of 1.62, 1.93, and 2.41, respectively. The results show that base drag and, in general, the total drag increase with increasing values of the ratio of base area to maximum area B/S(sub max), although the results reported in NACA TN 3054 showed that the wave drag decreased with increasing values of B/S(sub max). The laminar skin-friction drag is in agreement with the theoretical predictions used, and, within the Mach number range of these tests, the simple Blasius incompressible theory gives a satisfactory prediction. Except for values of B/S (sub max) near 1, the Reynolds number of transition increases with increasing Mach number and as this ratio approaches 1 this variation is seen to reverse. These variations in Reynolds number of transition with Mach number appear to be associated with the changes in pressure gradient over the rear of the bodies

An Interactive Text Message Survey as a Novel Assessment for Bedtime Routines in Public Health Research: Observational Study.

BACKGROUND: Traditional research approaches, especially questionnaires and paper-based assessments, limit in-depth understanding of the fluid dynamic processes associated with child well-being and development. This includes bedtime routine activities such as toothbrushing and reading a book before bed. The increase in innovative digital technologies alongside greater use and familiarity among the public creates unique opportunities to use these technical developments in research. OBJECTIVE: This study aimed to (1) examine the best way of assessing bedtime routines in families and develop an automated, interactive, text message survey assessment delivered directly to participants' mobile phones and (2) test the assessment within a predominately deprived sociodemographic sample to explore retention, uptake, feedback, and effectiveness. METHODS: A public and patient involvement project showed clear preference for interactive text surveys regarding bedtime routines. The developed interactive text survey included questions on bedtime routine activities and was delivered for seven consecutive nights to participating parents' mobile phones. A total of 200 parents participated. Apart from the completion of the text survey, feedback was provided by participants, and data on response, completion, and retention rates were captured. RESULTS: There was a high retention rate (185/200, 92.5%), and the response rate was high (160/185, 86.5%). In total, 114 participants provided anonymized feedback. Only a small percentage (5/114, 4.4%) of participants reported problems associated with completing the assessment. The majority (99/114, 86.8%) of participants enjoyed their participation in the study, with an average satisfaction score of 4.6 out of 5. CONCLUSIONS: This study demonstrated the potential of deploying SMS text message-based surveys to capture and quantify real-time information on recurrent dynamic processes in public health research. Changes and adaptations based on recommendations are crucial next steps in further exploring the diagnostic and potential intervention properties of text survey and text messaging approaches

Perceived Barriers and Facilitators for Bedtime Routines in Families with Young Children.

OBJECTIVES: Bedtime routines are a highly recurrent family activity with important health, social and behavioural implications. This study examined perceived barriers to, and facilitators of, formulating, establishing, and maintaining optimal bedtime routines in families with young children. DESIGN: Participants completed a semi-structured interview based on the Theoretical Domains Framework (TDF). Analysis followed a deductive approach. PARTICIPANTS: A total of 32 parents participated in the study. Most participants (N = 30) were females, were white (N = 25) and stay at home parents (N = 12). RESULTS: Key barriers included lack of appropriate knowledge and sources of information, problematic skills development, social influences, cognitive overload, and lack of motivation for change. Facilitators included social role, access to resources, positive intentions, beliefs about consequences and reinforcement. In particular, optimal bedtime routines were less likely to be enacted when parents were tired/fatigued and there was a strong effect of habit, with suboptimal routines maintained over time due to past experiences and a lack of awareness about the importance of a good bedtime routine. CONCLUSIONS: Several theory-based, and potentially modifiable, determinants of optimal bedtime routines were identified in this study, providing important information for future interventions. Several of the key determinants identified were transient (tiredness) and/or non-conscious (habit), suggesting that future interventions may need to be deployed in real time, and should extend beyond conventional techniques

Bedtime Routine Characteristics and Activities in Families with Young Children in the North of England.

Bedtime routines have been shown to have significant associations with health, wellbeing and development outcomes for children and parents. Despite the importance of bedtime routines, most research has been carried out in the United States, with little information on bedtime routine characteristics and activities for families in other countries such as the United Kingdom and England in particular. Additionally, little is known about the possible effects of weekends vs. weekdays on the quality of bedtime routines. Finally, traditional, retrospective approaches have been most used in capturing data on bedtime routines, limiting our understanding of a dynamic and complex behaviour. The aim of this study was to explore bedtime routine characteristics and activities in families in the North of England with a real-time, dynamic data collection approach and to examine possible effects of weekend nights on the quality of bedtime routines. In total, 185 parents with children ages 3 to 7 years old provided data around their bedtime routine activities using an automated text-survey assessment over a 7-night period. Information on socio-economic and demographic characteristics were also gathered during recruitment. A small majority of parents managed to achieve all crucial elements of an optimal bedtime routine every night, with 53% reporting brushing their children's teeth every night, 25% reading to their children every night and 30% consistently putting their children to bed at the same time each night. Results showed significant differences between weekend (especially Saturday) and weekday routines (F(1, 100) = 97.584, p < 0.001), with an additional effect for parental employment (F(1, 175) = 7.151, p < 0.05). Results highlight variability in bedtime routine activities and characteristics between families. Many families undertook, in a consistent manner, activities that are closely aligned with good practices and recommendations on what constitutes an optimal bedtime routine, while others struggled. Routines remained relatively stable during weekdays but showed signs of change over the weekend. Additional studies on mechanisms and elements affecting the formation, development and maintenance of bedtime routines are needed alongside studies on supporting and assisting families to achieve optimal routines

Role of Oxidative Stress and Neuroinflammation Response in Pain Brain Regions after Traumatic Brain Injury

Traumatic brain injury (TBI) affects approximately 3 million people annually, with 70-80% presenting with pain symptoms. Research has shown that increased reactive oxygen species (ROS) and neuroinflammation play a role in both pain and TBI, but the roles and interaction of oxidative stress and inflammation in TBI-related pain remain unclear. The purpose of the current study is to establish molecular data supporting proposed alterations in ROS and neuroinflammation in a mouse model of TBI in pain-related brain regions and to quantify how levels of these mediators change over time. Once the time course is determined, it will allow for optimal use of various interventions such as antioxidant and anti-inflammatory treatment. Male (n=54) and female (n=27) mice ages 7-14 weeks were exposed to moderate level TBI or sham control surgery. Microdissections from pain-related brain regions, such as anterior cingulate cortex, amygdala, and periaqueductal gray were taken at 24 hours (n= 26 males, 9 females), 7 days (n= 13 males, 9 females), and 14 days (n= 15 males, 9 females) post-TBI and used to quantify ROS and inflammatory cytokine levels using a cell-based fluorescence assay and an enzyme-linked absorbance assay, respectively. Data demonstrated complex patterns of ROS and cytokine activation that varied with region and time post-injury. These data will provide information leading to optimal intervention strategies to mitigate the increased oxidative stress and neuroinflammation post-TBI

A modified version of the BSID-II scales for cognitive matching of infants with and without Down syndrome

Background Many measures of infants’ early cognitive development, including the BSID-II, mix together test items that assess a number of different developmental domains including language, attention, motor functioning and social abilities, and some items contribute to the assessment of more than one domain. Consequently, the scales may lead to under- or over-estimates of cognitive abilities in some clinical samples and may not be the best measure to use for matching purposes. Method To address this issue we created a modified form of the BSID-II (the BSI-M) to provide a ‘purer’ assessment of the general cognitive capacities in infants with DS from 6 through to 18 months of age. We excluded a number of items that implicated language, motor, attentional and social functioning from the original measure. This modified form was administered to 17 infants with Down's syndrome when 6-, 12- and 18-months-old and to 41 typically developing infants at 4-, 7- and 10-months. Results The results suggested that the modified form continued to provide a meaningful and stable measure of cognitive functioning and revealed that DS infants may score marginally higher in terms of general cognitive abilities when using this modified form than they might when using the standard BSID-II scales. Conclusions This modified form may be useful for researchers who need a ‘purer’ measure with which to match infants with Down syndrome and other infants with IDs on cognitive functioning