CPI-E On Every Desktop!

Christian Periodical Index-Electronic is now beginning its third year of \u27-Production. Initial subscriptions to the index were made following conference in 1999 after the official ribbon cutting at Lee University in Cleveland, Tennessee. Since that time we have seen many libraries subscribe. The electronic version is available in both cd-rom format and via the Internet. Libraries have successfully setup access both by ip recognition and by password for patrons accessing the library\u27s databases remotely. This year the CPI Team decided to make a more conscious effort to market the product with several initiatives underway. These include direct mailings with a newly designed brochure, vendor booths at some strategic conferences in addition to our own ACL conference and a regular column in The Christian Librarian. This is our inaugural article for the column

The Evolution of Note Taking: A Study on Traditional Hard Copy Methods vs The Emerging Soft Copy Method

Being that we both have grown up in the midst of the digital age, we have seen many things evolve, develop, and go electronic; including the way students choose to learn in the classroom. It seems that more and more students are choosing to take notes via laptop, tablet, or smart phone, but with that said it also appears that just as many students are choosing to stick with the more traditional pen and paper way of note taking as well. For our research, we have studied the benefits that may attract students to either note taking method, as well as, researched the cons that may cause students to reject adopting either of the two. Finally, we discuss where note taking may be headed in the future. The answer matters to us because through our research we have been able to come across several studies in which discuss the benefits on digital devices in the classroom. We also find this topic interesting to research and see if the findings in the studies are true and if there are better methods for students to learn in a college classroom environment

Kava - the unfolding story: Report on a work-in-progress.

Journal of Alternative and Complementary Medicine, 8(3), 237-263

Methods in antibody discovery

Antibodies are an essential part of adaptive immunity and can be raised against almost any molecule. The ability to bind a wide variety of molecules with exquisite specificity, causes antibodies to be highly desirable tools for research and in medicine. Beginning with the discovery of antibodies in 1890 by Behring and Kitasato, the scientific community was aware of the enormous therapeutic potential of molecules that can be induced to bind any disease-causing factor. However, the realization of this potential was stifled by the lack of techniques to isolate and produce antibodies of defined specificity. Since then, versatile antibody discovery methods have been developed, however, initial antibody isolation and characterization remain a bottleneck in the antibody discovery process. The work presented here improves upon existing methods of antibody discovery. Development of a novel yeast surface display strain reduces selection times by half and expedites downstream development by use of a native antibody format that translates effortlessly into full-length antibodies. The combination of antibody yeast surface display and mass-spectrometry based protein sequencing of serum antibodies successfully isolates SARS-CoV-2 binders from infected donors. Additionally, examination of the role of antibody light chains leads to insights into repertoire diversity and sparks an innovative approach to antibody heavy and light chain pairing. Cumulatively, the synergistic use of these antibody discovery methods yields 49 SARS-CoV-2 neutralizing antibodies against a variety of spike protein epitopes. Four antibodies and their binding mode were structurally characterized, revealing overlap with known antigenic supersites of the spike protein, and a unique quaternary binding mode at the receptor binding domain.Biochemistr

Stability and Change of Personality across the Life Course: The Impact of Age and Major Life Events on Mean-Level and Rank-Order Stability of the Big Five

Does personality change across the entire life course, and are those changes due to intrinsic maturation or major life experiences? This longitudinal study investigated changes in the mean levels and rank order of the Big Five personality traits in a heterogeneous sample of 14,718 Germans across all of adulthood. Latent change and latent moderated regression models provided four main findings: First, age had a complex curvilinear influence on mean levels of personality. Second, the rank-order stability of Emotional Stability, Extraversion, Openness, and Agreeableness all followed an inverted U-shaped function, reaching a peak between the ages of 40 and 60, and decreasing afterwards, whereas Conscientiousness showed a continuously increasing rank-order stability across adulthood. Third, personality predicted the occurrence of several objective major life events (selection effects) and changed in reaction to experiencing these events (socialization effects), suggesting that personality can change due to factors other than intrinsic maturation.. - Fourth, when events were clustered according to their valence, as is commonly done,. - effects of the environment on changes in personality were either overlooked or. - overgeneralized. In sum, our analyses show that personality changes throughout the life. - span, but with more pronounced changes in young and old ages, and that this change is. - partly attributable to social demands and experiences.personality development, Big Five, life events, stability, adulthood