Bounds on Bess Model Parameters from Vector-Boson Production in e+e- Collisions

The BESS model is the Higgs-less alternative to the standard model of electroweak interaction, based on nonlinearly realized spontaneous symmetry breaking. Since it is nonrenormalizable, new couplings (not existing in the SM) are induced at each loop order. On the basis of the one loop induced vector-boson self-couplings we study the two- and three-vector-boson-production processes in $e^+e^-$ collisions at $\sqrt{s}=500 GeV$, the expected energy of the next $e^+e^-$ linear collider (NLC). Assuming that NLC results will agree with the SM predictions within given accuracy we identify the bounds for the free parameters of the BESS model.Comment: December 1992, 8 pages LaTeX, 6 figures (not included but available on request), BI-TP 92/59, LMU-92/1

Attribution of diabetes to the development of severe liver disease in the general population

Background and Aims: Diabetes is associated with advanced liver disease and predicts mortality regardless of the primary aetiology of the liver disease. Even a family history of diabetes has been linked to advanced liver fibrosis in non-alcoholic fatty liver disease (NAFLD). However, the fraction of liver-related outcomes in the general population that are attributable to diabetes remains unclear. Methods: The population attributable fraction (PAF) of diabetes for liver disease as a time-dependent exposure was estimated in the Finnish FINRISK study (n = 28 787) and the British Whitehall II study (n = 7855). We also assessed the predictive ability of a family history of diabetes for liver-related outcomes. Incident diabetes data were from drug purchase/reimbursement and healthcare registries (FINRISK) or follow-up examinations (Whitehall II). Incident severe liver outcomes were identified through linkage with national healthcare registries. Results: Diabetes was associated with a two-fold risk of liver-related outcomes in both the FINRISK (HR, 1.92; p <.001) and Whitehall II (HR, 2.37; p <.001) cohorts, and this remained significant after adjusting for multiple confounders. PAF analyses demonstrated that diabetes explained 12–14% of the risk for severe liver-related outcomes after 10 and 20 years of follow-up. Also, maternal diabetes increased the risk of liver-related outcomes in the FINRISK (HR, 1.43; p =.044) and Whitehall II (HR, 2.04; p =.051) cohorts. Conclusion: Approximately 12%–14% of severe liver-related outcomes are attributable to diabetes at the population level. The association between maternal diabetes and liver disease might suggest a mitochondrial genetic mechanism

Rapidly Progressive Malignant Rhabdoid Tumor of the Omentum in an Adult. A Case Report and Review of the Literature

Introduction: Malignant Rhabdoid Tumors (MRT) are exceedingly rare neoplasms that characteristically occur in infants and children and sparsely develop in adults. Primary MRTs of the omentum are particularly rare.Presentation of Case: A previously healthy 24-year-old male who presented with progressive abdominal distention and nausea. Further investigations revealed ascites with multifocal omental-based tumors. Biopsy with immunohistochemistry demonstrated dually positive cells for cytokeratin and vimentin and loss of Integrase Interactor 1 (INI1), and Next generation sequencing showed a copy number loss of SMARCB1 which established the diagnosis of malignant rhabdoid tumor. The patient’s clinical course was characterized by rapid local and metastatic progression with subsequent clinical deterioration, and he expired within three weeks of his initial presentation.Conclusion: Herein we describe the clinical course, difficulty with diagnosis, and paucity of treatment options for a rare and very aggressive malignant tumor. The ideal treatment regimen for MRTs has yet to be elucidated and additional studies are required to discern therapies that offer benefit

Measuring of free endotoxin in alum-precipitated vaccine of haemorrhagic septicaemia by limulus amebocyte lysate test

Summary Haemorrhagic septicaemia (HS) vaccine which is prepared in Razi Institute is used in endemic areas of Iran. Aluminum-hydroxide gel was used as adjuvant for preparing this vaccine. Post-vaccinal shock reactions were the main complaint after use of this vaccine. In a previous study, we could improve the vaccine by alum-precipitation Pasteurella multocida cells and removing the liquid phase. In this study, the amount of free endotoxin in aluminum-hydroxide and alum-HS vaccines was determined. It was found that endotoxin level was considerably decreased from 0.22 EU/ml to 0.03 EU/ml after alum-precipitation

Waist and hip circumference are independently associated with the risk of liver disease in population-based studies

Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 toPeer reviewe

Using Simulated Annealing to Solve the Daily Drayage Problem with Hard Time Windows

Drayage is the stage of the intermodal transport that deals with transport of freight on trucks among the intermodal terminal, and customers and suppliers that are located in its hinterland. This work proposes an algorithm based on simulated annealing heuristics to solve the operations of drayage. This algorithm has been used to solve battery problems, demonstrating the validity and suitability of its results, which were compared with exact method