Deworming and Development: Asking the Right Questions, Asking the Questions Right

Two billion people are infected with intestinal worms. In many areas, the majority of schoolchildren are infected, and the World Health Organization (WHO) has called for school-based mass deworming. The key area for debate is not whether deworming medicine works—in fact, the medical literature finds that treatment is highly effective, and thus the standard of care calls for treating any patient known to harbor an infection. As the authors of the Cochrane systematic review point out, a critical issue in evaluating current soil-transmitted helminth policies is whether the benefits of deworming exceed the costs or whether it would be more prudent to use the money for other purposes. While in general we think the Cochrane approach is very valuable, we argue below that many of the underlying studies of deworming suffer from three critical methodological problems: treatment externalities in dynamic infection systems, inadequate measurement of cognitive outcomes and school attendance, and sample attrition. We then argue that the currently available evidence from studies that address these issues is consistent with the consensus view expressed by other reviews and by policymakers that deworming is a very cost-effective way to increase school participation and has a high benefit to cost ratio.Economic

Early Detection of the Wear of Coriolis Flowmeters through In Situ Stiffness Diagnosis

Coriolis flowmeters have been widely employed in a variety of industrial applications. There is a potential that the measuring tube of a Coriolis flowmeter may be eroded when it is used to measure abrasive fluid such as slurry flow. However, it is challenging to verify the structural health of the flowmeter without process interruptions or using on-site calibration devices such as meter provers. This paper presents an in-situ structural health monitoring technique through stiffness diagnosis to identify the potential wear occurring on the measuring tube. To measure the frequency response of a Coriolis flowmeter which strongly depends on the structural characteristics of the tube, the tube is not only excited at a resonant frequency but also at two additional off-resonant frequencies. Through digital processing of the drive and sensor signals, the frequency response is obtained and a stiffness related diagnostic parameter (SRDP) is extracted from a Coriolis flowmeter. The proposed stiffness diagnosis technique was experimentally evaluated on a commercial bent-tube Coriolis flowmeter with dilute sand-water slurry flow. The results illustrate that the slight tube erosion is successfully identified when a relative change in SRDP reaches −1%, showing a good capability for an early detection of tube wear. In addition, the outcomes from recalibration with water suggest that, after the erosion occurs, the flowmeter overestimates the mass flowrate and underestimates the flow density

Measurement technologies for pipeline transport of carbon dioxide-rich mixtures for CCS

Carbon capture and storage (CCS) is necessary to achieve the long-term temperature goals of the Paris Agreement. The mass of CO₂ that will be transported for permanent storage by 2050, to meet the International Energy Agency (IEA)'s Sustainable Development Scenario, is of a similar scale to the current global market of natural gas. Such trading levels require significant and expedited technological efforts. The urgency of the climate goals requires technological innovations to build from existing technologies operating in similar environments. The present work aims to be a stepping stone towards the realisation of the CCS business, which relies on accurate metrology and tight control systems. Here, various established technologies are screened, and for each principle, their possible niches of operation within CCS are identified. Eight technologies were shortlisted and assessed against selected benchmarking criteria. The most promising solutions for the various operative scenarios encompassing bulk flow measurement, structural flow identification, composition, and leak detection are described. All surveyed technologies require further experimental verification for one or more of the operating schemes throughout the CCS value chain. A roadmap to further explore the applicability of various measurement principles in CCS is also provided.Measurement technologies for pipeline transport of carbon dioxide-rich mixtures for CCSpublishedVersio

Iron Deficiency Anemia and School Participation.

Abstract: Iron-deficiency anemia is among the world's most widespread health problems, especially for children, but it is rarely studied by economists. This paper evaluates the impact of a health intervention delivering iron supplementation and deworming drugs to 2-6 year old children through an existing pre-school network in the slums of Delhi, India. At baseline 69 percent of sample children were anemic and 30 percent had intestinal worm infections. Sample pre-schools were randomly divided into groups and gradually phased into treatment. Weight increased significantly among assisted children, and pre-school participation rates rose sharply by 5.8 percentage points -a reduction of one-fifth in school absenteeism -in the first five months of the program. Gains are largest in low socio-economic status areas. Year two estimates are similar, but two methodological problems -sample attrition, and the non-random sorting of new child cohorts into treatment groups -complicate interpretation of the later results

LIPID MAPS: Update to databases and tools for the lipidomics community

LIPID MAPS (LIPID Metabolites and Pathways Strategy), www.lipidmaps.org, provides a systematic and standardized approach to organizing lipid structural and biochemical data. Founded 20 years ago, the LIPID MAPS nomenclature and classification has become the accepted community standard. LIPID MAPS provides databases for cataloging and identifying lipids at varying levels of characterization in addition to numerous software tools and educational resources, and became an ELIXIR-UK data resource in 2020. This paper describes the expansion of existing databases in LIPID MAPS, including richer metadata with literature provenance, taxonomic data and improved interoperability to facilitate FAIR compliance. A joint project funded by ELIXIR-UK, in collaboration with WikiPathways, curates and hosts pathway data, and annotates lipids in the context of their biochemical pathways. Updated features of the search infrastructure are described along with implementation of programmatic access via API and SPARQL. New lipid-specific databases have been developed and provision of lipidomics tools to the community has been updated. Training and engagement have been expanded with webinars, podcasts and an online training school

Plan showing the condition of the harbor of Port Dalhousie in 1845 and the proposed improvements

Historical map showing the First and Second Welland Canal with the Third Welland Canal's proposed new harbor, inner harbor, outer harbor, lighthouse and bridge. Scale [ca. 1:1,920] Relief shown by shading and soundings. Map date: 1845 Digital reproduction of map in the Public Archives of Canada. National Map Collection. Library and Archives Canada. Georeferenced and modified from NMC Map number 4320 by Map, Data and GIS Library, Brock University