Quality of life in rectal cancer patients with permanent colostomy in Xi’an

Purposes: The aim of this study was to observe the quality of life (QOL) in rectal cancer patients with permanent colostomy in different periods after operation. Methods: A 1-,3-,6-month prospective study of QOL in 51 rectal cancer patients with permanent colostomy and 50 ones without permanent colostomy was assessed by using European Organization for Research and Treatment of Cancer (EORTC) QOL-30 and CR38 questionnaires. Results: The variation of QOL in different periods was “v” type. In the 1st postoperative month, these patients had the lowest quality of life scores, accompanied significantly varied functions and severe symptoms. Almost of all indexes of these patients had improved consistently in postoperative periods. The scores of global QOL even better than pre-operative level at 6th months post-operation, but the social function, body image, chemotherapy side effects and financial difficulties had not restored to the baseline level. Patients without permanent colostomy had a better score in most of categories of QOL-30 and CR38. Conclusions: The 1st postoperative month was crucial for patients’ recovery, in which we should pay great attention to these problems which relate to the recovery of rectal cancer patients with permanent colostomy.Keywords: Quality of life, Rectal cancer, Permanent colostomy, EORTC QOL-30 and CR38 questionnairesAfrican Health sciences Vol 14 No. 1 March 201

Simulation of thermal stress and fatigue life prediction of high speed steel work roll during hot rolling considering the initial residual stress

Considerable residual stress is produced during heat treatment. Compressive residual stress at the shell is conductive to improving the thermal fatigue life of a work roll, while tensile stress in the core could cause thermal breakage. In hot rolling, thermal stress occurs under the heating-cooling cycles over the roll surface due to the contact with the hot strip and water spray cooling. The combination of thermal stress and residual stress remarkably influences the life of a work roll. In this paper, finite element method (FEM) simulation of hot rolling is performed by treating the residual stress as the initial stress. Afterwards, the effects of the initial roll temperature and cooling conditions on thermal stress considering the initial residual stress are discussed. Lastly, the thermal fatigue life of a work roll is estimated based on the strain life model. The higher initial roll temperature causes a higher temperature but a lower compressive thermal stress at the roll surface. The surface temperature and compressive stress increase significantly in the insufficient cooling conditions, as well as the center tensile stress. The calculation of the fatigue life of a work roll based on the universal slopes model according to the 10% rule and 20% rule is reasonable compared with experimental results

Numerical Simulation of Thermal Field and Performance Study on H13 Die Steel-Based Wire Arc Additive Manufacturing

In order to explore the relationship between welding thermal cycles and the thermal field during the repair process of dies, a numerical simulation software (SYSWELD) was employed to construct a thermo-mechanical coupled model. The influence of various inter-layer cooling times was investigated on heat accumulation, residual stress, and deformation of the repaired component. The results showed that the numerical simulation results agreed well with experimental data. The temperature within the cladding layer gradually rose as the number of weld beads increased, leading to a more pronounced accumulation of heat. The residual stress exhibited a double-peak profile, where the deformation of the repaired component was large at both ends but small in the middle. The less heat was accumulated in the cladding layer with a prolonged cooling time. Meanwhile, the residual stress and deformation in the repaired component experienced a gradual decrease in magnitude. The numerical simulation results demonstrated that the microstructure of the repaired component predominantly consisted of martensite and residual austenite at the optimal cooling time (300 s). Furthermore, the microhardness and wear resistance of the cladding zone significantly surpassed those of the substrate. In conclusion, this study suggested the prolonged cooling time mitigated heat accumulation, residual stress, and deformation in repaired components, which provided a new direction for future research on the die steel repairments

MODELING HIGH DIMENSIONAL ASSET RETURNS USING A DYNAMIC SKEWED COPULA MODEL

We propose a dynamic skewed copula to model multivariate dependence in asset returns in a flexible yet parsimonious way. We then apply the model to 50 exchange traded funds. The new copula is shown to have better in-sample and out-of-sample performance than existing copulas. In particular, the dynamic model is able to capture increasing dependence patterns during the fixnancial crisis periods. It is crucial for investors to take dynamic dependence structure into account when modeling high dimensional returns.We propose a dynamic skewed copula to model multivariate dependence in asset returns in a flexible yet parsimonious way. We then apply the model to 50 exchange traded funds. The new copula is shown to have better in-sample and out-of-sample performance than existing copulas. In particular, the dynamic model is able to capture increasing dependence patterns during the fixnancial crisis periods. It is crucial for investors to take dynamic dependence structure into account when modeling high dimensional returns

Protective effect of asiaticoside on radiation-induced proliferation inhibition and DNA damage of fibroblasts and mice death

Radiation-induced injuries (RII) mainly result from reactive oxygen species (ROS), which are harmful compounds that can damage DNA. Asiaticoside (AC), one of the main functional components extracted from Centella asiatica, has potent pharmacological effects such as anti-inflammatory and anti-oxidant activity. However, its role in RII remains unclear

Efficient Robust Yield Method for Preparing Bacterial Ghosts by <i>Escherichia coli</i> Phage ID52 Lysis Protein E

Bacterial ghosts (BGs) are nonliving empty bacterial shells without cytoplasm retaining original morphology and identical antigenicity of natural bacteria, making them high potential and promising vaccine candidates and delivery vehicles. However, the low yield of commonly used BGs preparation methods limits its mass production and widely application. In order to improve BGs production, E. coli phage ID52 lysis protein E was introduced to generating BGs for the first time. Above all, we compared the lysis activity of lysis protein of E. coli phage φX174 and E. coli phage ID52 as well as the effects of promoters on the lysis activity of ID52-E, which shown that the lysis activity and BGs formation rate of protein ID52-E was significantly higher than protein φX174-E. Further, the lysis activity of ID52-E was significantly improved under the control of L-arabinose inducible promoter which initial induction OD600 reached as high as 2.0. The applicability of lysis protein ID52-E induced by L-arabinose was proved by preparing probiotic E. coli Nissle 1917 BGs and pathogenic Salmonella typhimurium BGs in mass production. This paper introduced a novel and highly efficient method for BGs preparation depending on recombinant expression of E. coli phage ID52-E under eco-friendly and reasonable price inducer L-arabinose

Prediction of Power Outage Quantity of Distribution Network Users under Typhoon Disaster Based on Random Forest and Important Variables

Typhoons can have disastrous effects on power systems. They may lead to a large number of power outages for distribution network users. Therefore, this paper establishes a model to predict the power outage quantity of distribution network users under a typhoon disaster. Firstly, twenty-six explanatory variables (called global variables) covering meteorological factors, geographical factors, and power grid factors are considered as the input variables. On this basis, the correlation between each explanatory variable and response variable is analyzed. Secondly, we established a global variable model to predict the power outage quantity of distribution network users based on Random Forest (RF) algorithm. Then the importance of each explanatory variable is mined to extract the most important variables. To reduce the complexity of the model and ease the burden of data collection, eight variables are eventually selected as important variables. Afterward, we predict the power outage quantity of distribution network users again using the eight important variables. Thirdly, we compare the prediction accuracy of a model called the No-model that has been used before, Linear Regression (LR), Support Vector Regression (SVR), Decision Tree Regression (DTR), RF-global variable model, and RF-important variable model. Simulation results show that the RF-important variable model proposed in this paper has a better effect. Since fewer variables can save prediction time and make the model simplified, it is recommended to use the RF-important variable model

Effect of Na2CO3 on the Microstructure and Macroscopic Properties and Mechanism Analysis of PVA/CMC Composite Film

Polyvinyl alcohol (PVA)/carboxyl methyl cellulose sodium (CMC)/Na2CO3 composite films with different contents of Na2CO3 were prepared by blending and solution-casting. The effect of Na2CO3 on the microstructure of PVA/CMC composite film was analyzed by Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and atomic force microscopy (AFM). Its macroscopic properties were analyzed by water sorption, solubility, and dielectric constant tests. The results show that the microstructure of PVA/CMC/Na2CO3 composite films was different from that of PVA and PVA/CMC composite films. In addition, compared to PVA and PVA/CMC composite films, the water sorption of PVA/CMC/Na2CO3 composite films relatively increased, the solubility in water significantly decreased, and the dielectric properties significantly improved. All these results indicate that the hydrogen bonding interaction between PVA and CMC increased and the crystallinity of PVA decreased after the addition of Na2CO3. This was also a direct factor leading to increased water sorption, decreased solubility, and enhanced dielectric properties. The reaction mechanism of PVA, CMC, and Na2CO3 is proposed to further evaluate the effect of Na2CO3 on the microstructure and macroscopic properties of PVA/CMC/Na2CO3 composite films

An Amide Alkaloid Isolated from <i>Ephedra sinica</i> Ameliorates OVA-Induced Allergic Asthma by Inhibiting Mast Cell Activation and Dendritic Cell Maturation

Asthma, which is a chronic inflammatory disease of the airways, is usually caused by allergens in which various structures and immune cells are involved. Ephedra sinica, the most commonly used Chinese medicine, has significant clinical effects on asthma, but its components are complex and the mechanism of action has not been fully elucidated. Among its components, we identified an amide alkaloid (EB-A) and investigated its anti-asthmatic activity and the underlying mechanisms. In this study, we replicated an OVA-sensitized/challenged allergic asthma mouse model, and divided the mice into a model (OVA) group, positive drug (Y, 0.5 mg/kg/day) group, and EB-A treatment with low (Low, 10 mg/kg/day) and high dose (High, 20 mg/kg/day) groups. Asthma-related features were analyzed through the airway hyperresponsiveness (AHR), cough and wheeze indexes, allergen-specific IgE, prostaglandin D2 (PDG2), and lung histology in mice. The levels of apoptosis and reactive oxygen species (ROS) in the primary lung cells, cytokines in the serum and broncho-alveolar lavage fluid (BALF), and proteinase-activated receptor-2 (PAR2) pathway activation in the lung tissue were measured to evaluate the inflammatory injury and lung epithelial barrier damage in the mice. Dendritic cell (DC) maturation and mast cell (MC) activation were verified in vitro and in vivo. Furthermore, the effect of a PAR2 activation in lung epithelial cells on the maturation of DCs was evaluated by the co-culture system of (human bronchial epithelial cell lines) 16HBE and bone marrow-derived dendritic cells (BMDCs). The results showed that EB-A inhibited the typical asthmatic phenotypes, as well as lung injury and inflammation, MC activation and degranulation, and DC maturation in the OVA-sensitized/challenged BALB/c mice. In addition, EB-A inhibited the expression of PAR2 in the lung epithelial cells and significantly interfered with the maturation of DCs after inhibiting PAR2. Taken together, our study firstly demonstrated that EB-A could ameliorate OVA-induced allergic asthma by inhibiting MC activation and DC maturation, and the molecular mechanism of EB-A’s anti-asthmatic activity might be mediated by inhibiting PAR2. Our data provide a molecular justification for the use of EB-A in the treatment of allergic asthma