Lithium-Ion Performance and Abuse Evaluation Using Lithium Technologies 9Ah cell

Lithium-ion batteries in a pouch form offer high energy density and safety in their designs and more recently they are offering performance at higher rates. Lithium Technologies 9Ah high-power pouch cells were studied at different rates, thermal environments, under vacuum and several different conditions of abuse including overcharge, over-discharge and external short circuit. Results of this study will be presented

Doktor Kot, Doktor Sla - book doctors, plant doctors and the segmentation of the medical market place in Meghalaya, northeast India.

Despite decades of research on India's plural health care market, the practices of many local health traditions outside the allopathic and codified traditions are under-studied. Drawing on interview and observational data, this paper explores the space in which indigenous traditional Khasi healers in Meghalaya state, northeast India, practice. Khasi indigenous healers describe themselves as doktor sla, plant doctors, to distinguish themselves from doktor kot, or book doctors. This distinction operates as a rhetorical resource, utilised to carve a distinct sphere of expertise in relation to the allopathic sector, and to mark claims for the specifically local appropriateness of traditional practices within a shifting market of state-sponsored provision. Khasi healers are a heterogeneous group who treat a wide variety of conditions, including physical ailments which have no obvious correlates in biomedical systems, and musculoskeletal disorders, with which they have recognised expertise. In addition to claiming these discrete strengths, healers also present themselves as accommodating deficiencies in biomedicine, including inherent generic weaknesses of allopathic care as well as specific local gaps in rural health care provision. Thus, the expertise niches of traditional healers have evolved through their interactions with, and the needs of, the community, but also through managing a shifting boundary with biomedical practitioners, who are explicitly sceptical of their efficacy, but tacitly accepting of the ways in which they manage the gaps in biomedical provision. While codified non-biomedical traditions in India have engaged in universalising professionalising projects, in this setting at least, non-codified practitioners have instead utilised discourses of localism

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

Bloom syndrome (BS) is a hereditary disorder characterized by pre- and postnatal growth retardation, genomic instability, and cancer. BLM, the gene defective in BS, encodes a DNA helicase thought to participate in genomic maintenance. We show that BS human fibroblasts undergo extensive apoptosis after DNA damage specifically when DNA replication forks are stalled. Damage during S, but not G1, caused BLM to rapidly form foci with γH2AX at replication forks that develop DNA breaks. These BLM foci recruited BRCA1 and NBS1. Damaged BS cells formed BRCA1/NBS1 foci with markedly delayed kinetics. Helicase-defective BLM showed dominant-negative activity with respect to apoptosis, but not BRCA1/NBS1 recruitment, suggesting catalytic and structural roles for BLM. Strikingly, inactivation of p53 prevented the death of damaged BS cells and delayed recruitment of BRCA1/NBS1. These findings suggest that BLM is an early responder to damaged replication forks. Moreover, p53 eliminates cells that rapidly assemble BRCA1/NBS1 without BLM, suggesting that BLM is essential for timely BRCA1/NBS1 function

Fertility intentions and use of contraception among monogamous couples in northern Malawi in the context of HIV testing: a cross-sectional analysis.

CONTEXT: Knowledge of HIV status may influence fertility desires of married men and women. There is little knowledge about the importance of this influence among monogamously married couples and how knowledge of HIV status influences use of contraception among these couples. METHODOLOGY: We carried out a cross-sectional analysis of interview data collected between October 2008 and September 2009 on men aged 15-59 years and women aged 15-49 years who formed 1766 monogamously married couples within the Karonga Prevention Study demographic surveillance study in northern Malawi. RESULTS: 5% of men and 4% of women knew that they were HIV positive at the time of interview and 81% of men and 89% of women knew that they were HIV negative. 73% of men and 83% of women who knew that they were HIV positive stated that they did not want more children, compared to 35% of men and 38% of women who knew they were HIV negative. Concordant HIV positive couples were more likely than concordant negative couples to desire to stop child bearing (odds ratio 11.5, 95%CI 4.3-30.7, after adjusting for other factors) but only slightly more likely to use contraceptives (adjusted odds ratio 1.5 (95%CI 0.8-3.3). CONCLUSION: Knowledge of HIV positive status is associated with an increase in the reported desire to cease childbearing but there was limited evidence that this desire led to higher use of contraception. More efforts directed towards assisting HIV positive couples to access and use reproductive health services and limit HIV transmission among couples are recommended

Impact of cyclooxygenase inhibitors in the Women's Health Initiative hormone trials: secondary analysis of a randomized trial.

OBJECTIVES: We evaluated the hypothesis that cyclooxygenase (COX) inhibitor use might have counteracted a beneficial effect of postmenopausal hormone therapy, and account for the absence of cardioprotection in the Women's Health Initiative hormone trials. Estrogen increases COX expression, and inhibitors of COX such as nonsteroidal anti-inflammatory agents appear to increase coronary risk, raising the possibility of a clinically important interaction in the trials. DESIGN: The hormone trials were randomized, double-blind, and placebo-controlled. Use of nonsteroidal anti-inflammatory drugs was assessed at baseline and at years 1, 3, and 6. SETTING: The Women's Health Initiative hormone trials were conducted at 40 clinical sites in the United States. PARTICIPANTS: The trials enrolled 27,347 postmenopausal women, aged 50-79 y. INTERVENTIONS: We randomized 16,608 women with intact uterus to conjugated estrogens 0.625 mg with medroxyprogesterone acetate 2.5 mg daily or to placebo, and 10,739 women with prior hysterectomy to conjugated estrogens 0.625 mg daily or placebo. OUTCOME MEASURES: Myocardial infarction, coronary death, and coronary revascularization were ascertained during 5.6 y of follow-up in the estrogen plus progestin trial and 6.8 y of follow-up in the estrogen alone trial. RESULTS: Hazard ratios with 95% confidence intervals were calculated from Cox proportional hazard models stratified by COX inhibitor use. The hazard ratio for myocardial infarction/coronary death with estrogen plus progestin was 1.13 (95% confidence interval 0.68-1.89) among non-users of COX inhibitors, and 1.35 (95% confidence interval 0.86-2.10) among continuous users. The hazard ratio with estrogen alone was 0.92 (95% confidence interval 0.57-1.48) among non-users of COX inhibitors, and 1.08 (95% confidence interval 0.69-1.70) among continuous users. In a second analytic approach, hazard ratios were calculated from Cox models that included hormone trial assignment as well as a time-dependent covariate for medication use, and an interaction term. No significant interaction was identified. CONCLUSIONS: Use of COX inhibitors did not significantly affect the Women's Health Initiative hormone trial results

La col·lecció numismàtica del Museu d’Alcoi. Època medieval

Presentem l’última part de la col·lecció numismàtica del Museu Arqueològic Municipal d’Alcoi, que correspon en aquest cas a les monedes d’època medieval. Es tracta d’un repertori de 29 peces, moltes inèdites, de les quals 13 són monedes islàmiques i 15 cristianes, a més a més d’un getó

The numismatic collection of the Alcoi Archaeological Museum (Spain). Modern times

152 monedes, tant espanyoles com estrangeres, que abracen un període cronològic comprés entre els segles XV i la primera dècada del s. XIX, les quals, gairebé totes, són inèdites. Paraules clau: Col·lecció numismàtica. Època moderna. Monedes. Getó.Museum (Spain). The set is composed of 152 coins, ranging from the 15th century up to the first decade of 19th century AD, all of them as yet unpublished. Key words: Numismatic collection. Modern times. Coins. Thick-lipped.Se presenta la catalogación del fondo numismático de época moderna de la colección del Museu Arqueològic Municipal de Alcoi. Se trata de un repertorio de 152 monedas, tanto españolas como extranjeras, que abarcan un período cronológico comprendido entre los siglos XV y la primera década del s. XIX, prácticamente todas ellas inéditas. Palabras clave: Colección numismática. Época Moderna. Monedas. Jetón

La col·lecció numismàtica del Museu d’Alcoi. Època contemporània

Es presenta la catalogació del fons numismàtic d’època contemporània de la col•lecció del Museu Arqueològic Municipal d’Alcoi. Es tracta d’un repertori de 101 monedes i medalles, tant espanyoles com estrangeres, que abracen un període cronològic comprés entre els segles XIX i XX; gairebé totes aquestes són inèdites. Paraules clau: Col•lecció numismàtica. Època contemporània. Monedes. Medalles.In this article we present the catalogue of the Contemporary Age numismatic holdings from the collection of the Alcoi Municipal Archaeological Museum (Alicante, Spain). This set or ensemble is composed of 101 coins and medals, encompassing between the 19th and 20th centuries AD, almost all of them as yet unpublished. Key words: Numismatic collection. Contemporary Age. Coins. Medals.Se presenta la catalogación del fondo numismático de época contemporánea de la colección del Museu Arqueològic Municipal de Alcoi. Se trata de un repertorio de 101 monedas y medallas, tanto españolas como extranjeras, que abarcan un período cronológico comprendido entre los siglos XIX-XX, prácticamente todas ellas inéditas. Palabras clave: Colección numismática. Época contemporánea. Monedas. Medallas

PBH in single field inflation: the effect of shape dispersion and non-Gaussianities

Primordial black holes (PBHs) may result from high peaks in a random field of cosmological perturbations. In single field inflationary models, such perturbations can be seeded as the inflaton overshoots a small barrier on its way down the potential. PBHs are then produced through two distinct mechanisms, during the radiation era. The first one is the familiar collapse of large adiabatic overdensities. The second one is the collapse induced by relic bubbles where the inflaton field is trapped in a false vacuum. The latter are due to rare backward fluctuations of the inflaton which prevented it from overshooting the barrier in horizon sized regions. We consider (numerically and analytically) the effect of non-Gaussianities on the threshold for overdensities to collapse into a PBH. Since typical high peaks have some dispersion in their shape or profile, we also consider the effect of such dispersion on the corresponding threshold for collapse. With these results we estimate the most likely channel for PBH production as a function of the non-Gaussianity parameter fNL. We also compare the threshold for collapse coming from the perturbative versus the non perturbative template for the non-Gaussianity arising in this model. We show that i) for fNL gsim 3.5, the population of PBH coming from false vacuum regions dominates over that which comes from the collapse of large adiabatic overdensities, ii) the non-perturbative template of the non-Gaussianities is important to get accurate results. iii) the effect of the dispersion is small in determining the threshold for the compaction function, although it can be appreciable in determining the threshold amplitude for the curvature perturbation at low fNL. We also confirm that the volume averaged compaction function provides a very accurate universal estimator for the threshold