21 research outputs found
Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate
Spo艂eczno-ekonomiczne i przestrzenne przemiany struktur regionalnych Vol. 2
Praca recenzowana / peer-reviewed pape
The use of the LiDAR data-based digital terrain model in studies of river channels, on the example of the Skawica and the Sopotnia Wielka rivers
Od lat 80-90. XX w. rozwijana jest technika pozyskiwania danych przestrzennych za pomoc膮 teledetekcyjnego skaningu laserowego (LiDAR), kt贸ra znalaz艂a zastosowanie w wielu dziedzinach nauki m.in. w geografii, archeologii i in偶ynierii. W tym artykule dokonano oceny tych danych w identyfikacji niekt贸rych naturalnych i antropogenicznych form w korytach dw贸ch g贸rskich ciek贸w (Skawicy i Sopotni Wielkiej). Interpretacja numerycznego modelu terenu wygenerowanego z danych LiDAR, po艂膮czona z weryfikacj膮 terenow膮 pokaza艂a, 偶e mo偶liwa jest precyzyjna identyfikacja prog贸w rzecznych, kt贸rych wysoko艣膰 wynosi艂a co najmniej 0,8 m (zosta艂y odnalezione wszystkie formy), a cz臋艣ciowo nawet mniejszych (do 0,5 m). Zaproponowano te偶 spos贸b wizualizacji danych LiDAR, u艂atwiaj膮cy identyfikacje tego typu obiekt贸w oraz om贸wiono ich wp艂yw na wyniki analiz hydrologicznych.The technology of obtaining spatial information by remote sensing with LiDAR (Light Detection and Ranging), used in geographical, archaeological and engineering studies, has been developed since the 1980s and 1990s. This paper presents the results of evaluation of the LiDAR data-based digital elevation model in identifying small forms of mountain river beds. The interpretation of this model was verified by field mapping conducted in two streams in the Polish Carpathians, i.e. those of the Skawica and the Sopotnia Wielka. Considerable possibilities of identifying channel forms such as rapids or cascades, with a height of up to 0.8 m (and in the case of some structures up to 0.5 m), were observed. The way of interpretation of these structures and their potential influence on LiDAR-based hydrological analyses were also discussed
Geochemical analyses of recent sediments from Lake Morzycko against selected physiographic parameters of the S艂ubia River catchment (Western Poland)
This paper presents the results of a study on the content of lithogeochemical components (organic matter, Na, K, Mg, Ca, Mn, Fe, Cu and Zn) and grain-size composition of mineral matter in the bottom sediments of Morzycko Lake (My艣lib贸rz Lakeland, NW Poland). This lake is large (342.7 ha) and deep (69 m). The catchment has a typical forested character (mainly in the middle part of the S艂ubia River valley) with agricultural area (mainly in the upland areas north of the lake). The diversity of concentrations of metals was analysed based on 44 samples from 22 representative sites, including surface sediments and sediments from 5 cm below the current lake bed. The results showed that the chemical composition and granulometry of bottom sediments depends on contemporary morphogenetic processes in the catchment of the S艂ubia River. Geochemical and grain-size indices varied due to changes in biological productivity, intensity of weathering of postglacial material making up the catchment, and potential for migration of metals to the lake with surface or underground runoff. An important aspect in assessing the degree of enrichment of the sediments in trace elements is the location of shallow parts of the lake near the tourist districts of Mory艅
Synthesis of a new series of aryl/heteroarylpiperazinyl derivatives of 8-acetyl-7-hydroxy-4-methylcoumarin with low nanomolar 5-HT1A affinities
HBK-14 and HBK-15, triple 5-HT1A, 5-HT7 and 5-HT3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice
5-HT1A and 5-HT2A receptors affinity, docking studies and pharmacological evaluation of a series of 8-acetyl-7-hydroxy-4-methylcoumarin derivatives
E-commerce and last mile delivery technologies in the European countries
Society, companies and institutions are involved in a digital transformation that can be pervaded in various industries or sectors, and this also applies to communication, sales and distribution channels. The possibilities of e-commerce have also increased and world trade has been further developed. In 2020, more than two billion people bought goods or services over the Internet. Customer satisfaction depends on the solution of the last mile process, the method of picking up shipments as well as the time and place of picking up the shipment. The most common forms of off-premises delivery are automated parcel locker or machine (APM) and pick-up and drop-off delivery (PUDO). The aim of the paper is to analyse the level of the PUDO and APM network in European countries and in the V4 countries with regard to the size of the country and the population. For this purpose, it was necessary to focus on determining the population per 1 PUDO and the number of inhabitants per 1 APM in individual European countries and subsequently in the V4 countries. The obtained data were processed and recalculated in Excel. The results showed that within European countries the best values were achieved by Finland with 526 inhabitants per 1 PUDO and Spain with 188 inhabitants per 1 APM. Regarding the V4 countries, the Czech Republic achieved the best value in the case of inhabitants on PUDO with 729 inhabitants per 1 PUDO and in the case of APM Poland with 3,184 inhabitants per 1 APM
Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems
Oxidation Behavior of the Monolayered La2Zr2O7, Composite La2Zr2O7 + 8YSZ, and Double-Ceramic Layered La2Zr2O7/La2Zr2O7 + 8YSZ/8YSZ Thermal Barrier Coatings
The degradation process of thermal barrier coatings (TBCs) such as monolayered La2Zr2O7, composite 50% La2Zr2O7 + 50% 8YSZ, and double-ceramic layer (DCL) La2Zr2O7/50% La2Zr2O7 + 50% 8YSZ/8YSZ was investigated. Coatings were deposited using the atmospheric plasma spraying (APS) process (ceramic layer and bond-coat) on the Ni-based superalloy substrate with Ni-22Cr-10Al-1Y bond-coat. The thickness of the ceramic top-coats in all cases were 300 µm. In the case of La2Zr2O7/8YSZ, the internal sublayer was built from 8YSZ powder whereas the outer from La2Zr2O7. Between both sublayers’ “composite” a 50% La2Zr2O7 + 50% 8YSZ zone was present. The “composite” 50% La2Zr2O7 + 50% 8YSZ TBC system was sprayed from two different feedstock powders with equal weight ratios. In the first part of the investigation, the microstructural characterization of the TBCs was presented. The main goals were related to the characterization of the degradation processes in different TBC systems with special emphasis on the phenomenon in the thermally grown oxide (TGO) zone related to oxidation, and the phenomenon related to phase stability in ceramic top-coats as related to temperature influence. The oxidation test was carried out in air at 1100 °C for 500 h. In the second step of the investigation, the numerical simulation of the monolayered TBC 8YSZ and La2Zr2O7 systems was analyzed from the stress distribution point of view. Additionally, the two-layered TBC coating of the DCL type was also analyzed