Vision based interface system for hands free control of an intelligent wheelchair

<p>Abstract</p> <p>Background</p> <p>Due to the shift of the age structure in today's populations, the necessities for developing the devices or technologies to support them have been increasing. Traditionally, the wheelchair, including powered and manual ones, is the most popular and important rehabilitation/assistive device for the disabled and the elderly. However, it is still highly restricted especially for severely disabled. As a solution to this, the Intelligent Wheelchairs (IWs) have received considerable attention as mobility aids. The purpose of this work is to develop the IW interface for providing more convenient and efficient interface to the people the disability in their limbs.</p> <p>Methods</p> <p>This paper proposes an intelligent wheelchair (IW) control system for the people with various disabilities. To facilitate a wide variety of user abilities, the proposed system involves the use of face-inclination and mouth-shape information, where the direction of an IW is determined by the inclination of the user's face, while proceeding and stopping are determined by the shapes of the user's mouth. Our system is composed of electric powered wheelchair, data acquisition board, ultrasonic/infra-red sensors, a PC camera, and vision system. Then the vision system to analyze user's gestures is performed by three stages: detector, recognizer, and converter. In the detector, the facial region of the intended user is first obtained using Adaboost, thereafter the mouth region is detected based on edge information. The extracted features are sent to the recognizer, which recognizes the face inclination and mouth shape using statistical analysis and <it>K</it>-means clustering, respectively. These recognition results are then delivered to the converter to control the wheelchair.</p> <p>Result & conclusion</p> <p>The advantages of the proposed system include 1) accurate recognition of user's intention with minimal user motion and 2) robustness to a cluttered background and the time-varying illumination. To prove these advantages, the proposed system was tested with 34 users in indoor and outdoor environments and the results were compared with those of other systems, then the results showed that the proposed system has superior performance to other systems in terms of speed and accuracy. Therefore, it is proved that proposed system provided a friendly and convenient interface to the severely disabled people.</p

A well-balanced lattice Boltzmann model for binary fluids based on the incompressible phase-field theory

Spurious velocities arising from the imperfect offset of the undesired term at the discrete level are frequently observed in numerical simulations of equilibrium multiphase flow systems using the lattice Boltzmann equation (LBE) method. To capture the physical equilibrium state of two-phase fluid systems and eliminate spurious velocities, a well-balanced LBE model based on the incompressible phase-field theory is developed. In this model, the equilibrium distribution function for the Cahn-Hilliard (CH) equation is designed by treating the convection term as a source to avoid the introduction of undesired terms, enabling achievement of possible discrete force balance. Furthermore, this approach allows for the attainment of a divergence-free velocity field, effectively mitigating the impact of artificial compression effects and enhancing numerical stability. Numerical tests, including a flat interface problem, a stationary droplet, and the coalescence of two droplets, demonstrate the well-balanced properties and improvements in the stability of the present model

快速康复外科理念在妇科经腹手术围手术期护理中的应用分析

Objective: In order to speed up the rehabilitation of patients, reduce the incidence of complications, shorten the hospitalization time, and improve the satisfaction of patients, explore the application value of fast track surgery in perioperative nursing intervention. Methods: Retrospectived analysis the 120 cases patients with ovarian cysts, uterine fibroids and other gynecological diseases, in the hospital, from January to December in 2014. And randomly divided them into control group and experimental group, each group of 60 cases. Patients in control group were treated with traditional nursing intervention, and the experimental group was treated with the concept of rapid rehabilitation surgery nursing interventions. Compared of the two groups of patients in hospital time, the first defecation time, hospitalization expenses, satisfaction with care and postoperative complications. Results: The experimental group’s hospitalization time, defecation time, incidence of complications were significantly lower than the control group’s, but the nursing satisfaction was significantly higher than that of the control group’s (р&lt;0.05). Conclusion: The application of the concept of rapid rehabilitation surgery in perioperative nursing intervention can effectively accelerate the rehabilitation of patients, shorten hospitalization time, reduce the costs of hospitalization, and reduce the incidence of complications. And the clinical application effect is good. It is worth to be further promoted.目的 分析探讨快速康复外科理念对妇科围手术期进行护理干预的应用价值，以便加快患者的康复，减少并发症的发生，缩短住院时间，提高患者满意度。方法 回顾性分析本院2014年1月—12月收治的120例患卵巢囊肿、子宫肌瘤等疾病的妇科患者，将其随机分为对照组和试验组，每组各60例。对照组患者采用传统的护理干预措施，试验组患者采用快速康复外科理念进行护理干预。比较两组患者的住院时间、首次排便时间、住院费用、对护理的满意度以及术后并发症的发生情况。结果 试验组患者的住院时间、排便时间、并发症的发生率均显著低于对照组，护理满意度明显高于对照组（р&lt;0.05）。结论 应用快速康复外科理念对妇科围手术期患者进行护理干预能够有效加快患者的康复，缩短住院时间，减少住院费用，降低并发症的发生率，具有良好的临床应用效果，值得进一步推广使用

Common genetic variants in ADCY5 and gestational glycemic traits.

Two meta-analysis of genome wide association studies identified two variants at adenylate cyclase 5 (ADCY5) associated with type 2 diabetes mellitus, fasting and 2-hour glucose in non-pregnant individuals of European descent. The objective of our study was to explore the role of common variants in ADCY5 on gestational glycemic traits, including plasma glucose, insulin values, β cell function and insulin resistance in the fasted state as well as plasma glucose 1 hour after a 50-gram glucose challenge test among Chinese Han women. Homoeostasis model assessment (HOMA) was used to quantify β cell function (HOMA1-β and HOMA2-β) and insulin resistance (HOMA1-IR and HOMA2-IR). Thirty-five single nucleotide polymorphisms (SNPs) in ADCY5 were genotyped in 929 unrelated Chinese Han women with singleton pregnancies. Three SNPs (rs6797915, rs9856662 and rs9875803) displayed evidence for association with plasma glucose 1 hour after a 50-gram glucose challenge test (P = 0.042, 0.018 and 0.018, respectively), one (rs6777397) displayed evidence for association with HOMA1-β (P = 0.014), and one (rs6762009) displayed evidence for association with HOMA1-IR (P = 0.033). These results provide additional insight into the effects of genetic variation within ADCY5 in glucose metabolism, especially during pregnancy and in non-European descent populations

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.

Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone formation through phosphorylation of serine 14 (S14) on Inhibitor of DNA binding 2 (Id2). This enhances Id2 protein stability by means of escape from proteasomal degradation, and steers its localization to the growth cone, where Id2 interacts with radixin that is critical for growth cone formation. Knockdown of Id2, or abrogation of Id2 phosphorylation at S14, greatly impairs axon growth and the architecture of growth cone. Intriguingly, reinstatement of Akt/Id2 signaling after injury in mouse hippocampal slices redeemed growth promoting ability, leading to obvious axon regeneration. Our results suggest that Akt/Id2 signaling is a key module for growth cone formation and axon growth, and its augmentation plays a potential role in CNS axonal regeneration

Comparison of Clinical Outcomes Following Gefitinib and Erlotinib Treatment in Non–Small-Cell Lung Cancer Patients Harboring an Epidermal Growth Factor Receptor Mutation in Either Exon 19 or 21

Background:Gefitinib and erlotinib, small-molecule kinase inhibitors that block epidermal growth factor receptor (EGFR) signaling, have demonstrated a dramatic response rate and prolonged progression-free survival (PFS) in patients harboring an activating EGFR mutation. We compared the clinical outcomes in gefitinib- and erlotinib-treated patients harboring EGFR mutations who had recurrent or metastatic non–small-cell lung cancer (NSCLC).Methods:A total of 375 patients with recurrent or metastatic stage IIIB/IV NSCLC, who had either exon 19 deletion or the L858R mutation in exon 21, and had received either gefitinib (n = 228) or erlotinib (n = 147), were included in the study. A matched-pair case-control study design was implemented in the analysis, where 121 pairs of gefitinib-treated and erlotinib-treated patients were matched according to sex, smoking history, Eastern Cooperative Oncology Group performance status, and types of EGFR mutation.Results:The median age of all patients was 58 years (range, 30–84), and more than half of patients had never been smokers (63.6%). Most patients had adenocarcinoma (98.3%) and good Eastern Cooperative Oncology Group performance status (0, 1) (90.9%). The median number of cycles of EGFR tyrosine kinase inhibitor (TKI) treatment was 12.7 in the gefitinib group and 10.8 in the erlotinib group. Of the 242 patients, 63 (26%) received EGFR TKI as first-line therapy. The overall response rates and disease control rates in the gefitinib- or erlotinib-treated groups were 76.9% versus 74.4% (p = 0.575) and 90.1% versus 86.8%, respectively (p = 0.305). There was no statistically significant difference with regard to PFS (median, 11.7 versus 9.6; p = 0.056) between the gefitinib- and erlotinib-treated groups. For patients receiving EGFR TKI as the first-line treatment, there was no significant difference between the two treatment groups in overall response rates (76.7% and 90.0%) (p = 0.431) and median PFS (11.7 versus 14.5 months) (p = 0.507).Conclusion:In NSCLC patients harboring EGFR mutation, treatment with gefitinib and erlotinib resulted in similar effectiveness

Basaloid Squamous Cell Carcinoma in Nasal Cavity

Basaloid squamous cell carcinoma (BSCC) is often founded in the head and neck region. However, BSCC in the sinonasal tract is rare. We report here on the case of a 58-yr-old woman who presented with nasal obstruction and epistaxis. Computed tomography and examination of the nasal cavity revealed a tumor mass that originated from the right inferior turbinate with erosion of the nasal floor. The tumor that was attached to the inferior turbinate, the lateral nasal wall and the eroded right side hard palate, and so all this was resected. Histopathologic examination of the excised tumor confirmed BSCC in the nasal cavity. We report here on a nasal cavity BSCC that was treated with partial maxillectomy only