15,044 research outputs found
Further development of an in vitro model for studying the penetration of chemicals through compromised skin
A new in vitro model based on the electrical resistance properties of the skin barrier has been established in this laboratory. The model utilises a tape stripping procedure in dermatomed pig skin that removes a specific proportion of the stratum corneum, mimicking impaired barrier function observed in humans with damaged skin. The skin penetration and distribution of chemicals with differing physicochemical properties, namely; Benzoic acid, 3-Aminophenol, Caffeine and Sucrose has been assessed in this model. Although, skin penetration over 24 h differed for each chemical, compromising the skin did not alter the shape of the time course profile, although absorption into receptor fluid was higher for each chemical. Systemic exposure (receptor fluid, epidermis and dermis), was marginally higher in compromised skin following exposure to the fast penetrant, Benzoic acid, and the slow penetrant Sucrose. The systemically available dose of 3-Aminophenol increased to a greater extent and the absorption of Caffeine was more than double in compromised skin, suggesting that Molecular Weight and Log Pow, are not the only determinants for assessing systemic exposure under these conditions. Although further investigations are required, this in vitro model may be useful for prediction of dermal route exposure under conditions where skin barrier is impaired
The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases
The intestinal microbiota is recognized to play a role in the defense against infection, but conversely also acts as a reservoir for potentially pathogenic organisms. Disruption to the microbiome can increase the risk of invasive infection from these organisms; therefore, strategies to restore the composition of the gut microbiota are a potential strategy of key interest to mitigate this risk. Fecal (or Intestinal) Microbiota Transplantation (FMT/IMT), is the administration of minimally manipulated screened healthy donor stool to an affected recipient, and remains the major ‘whole microbiome’ therapeutic approach at present. Driven by the marked success of using FMT in the treatment of recurrent Clostridioides difficile infection, he potential use of FMT in treating other infectious diseases is an area of active research. In this Review, we discuss key examples of this treatment based on recent findings relating to the interplay between microbiota and infection, and potential further exploitations of FMT/IMT
Stellar Collisions and the Interior Structure of Blue Stragglers
Collisions of main sequence stars occur frequently in dense star clusters. In
open and globular clusters, these collisions produce merger remnants that may
be observed as blue stragglers. Detailed theoretical models of this process
require lengthy hydrodynamic computations in three dimensions. However, a less
computationally expensive approach, which we present here, is to approximate
the merger process (including shock heating, hydrodynamic mixing, mass
ejection, and angular momentum transfer) with simple algorithms based on
conservation laws and a basic qualitative understanding of the hydrodynamics.
These algorithms have been fine tuned through comparisons with the results of
our previous hydrodynamic simulations. We find that the thermodynamic and
chemical composition profiles of our simple models agree very well with those
from recent SPH (smoothed particle hydrodynamics) calculations of stellar
collisions, and the subsequent stellar evolution of our simple models also
matches closely that of the more accurate hydrodynamic models. Our algorithms
have been implemented in an easy to use software package, which we are making
publicly available (see http://vassun.vassar.edu/~lombardi/mmas/). This
software could be used in combination with realistic dynamical simulations of
star clusters that must take into account stellar collisions.Comment: This revised version has 37 pages, 13 figures, 4 tables; submitted to
ApJ; for associated software package, see
http://vassun.vassar.edu/~lombardi/mmas/ This revised version presents
additional comparisons with SPH results and slightly improved merger recipe
Near-Field Analysis of Terahertz Pulse Generation From Photo-Excited Charge Density Gradients
Excitation of photo-current transients at semiconductor surfaces by subpicosecond optical pulses gives rise to emission of electromagnetic pulses of terahertz (THz) frequency radiation. To correlate the THz emission with the photo-excited charge density distribution and the photo-current direction, we mapped near-field and far-field distributions of the generated THz waves from GaAs and Fe-doped InGaAs surfaces. The experimental results show that the charge dynamics in the plane of the surface can radiate substantially stronger THz pulses than the charge dynamics in the direction normal to the surface, which is generally regarded as the dominant origin of the emission
Does enforcement deter cartels? A tale of two tails
This paper investigates the deterrent impact of anti-cartel enforcement. It is shown theoretically that if enforcement is effective in deterring and constraining cartels then there will be fewer cartels with low overcharges and fewer with high overcharges. This prediction provides an indirect method for testing whether the enforcement of competition law is effective. Using historical data on legal cartels to generate the counterfactual, we find significantly less mass in the tails of the overcharge distribution, compared to illegal cartels. This result is robust to controlling for confounding factors, and we interpret this as the first tentative confirmation of effective deterrence
Atmospheric extinction coefficients in the band for several major international observatories: Results from the BiSON telescopes, 1984 to 2016
Over 30 years of solar data have been acquired by the Birmingham Solar
Oscillations Network (BiSON), an international network of telescopes used to
study oscillations of the Sun. Five of the six BiSON telescopes are located at
major observatories. The observational sites are, in order of increasing
longitude: Mount Wilson (Hale) Observatory (MWO), California, USA; Las Campanas
Observatory (LCO), Chile; Observatorio del Teide, Iza\~{n}a, Tenerife, Canary
Islands; the South African Astronomical Observatory (SAAO), Sutherland, South
Africa; Carnarvon, Western Australia; and the Paul Wild Observatory, Narrabri,
New South Wales, Australia. The BiSON data may be used to measure atmospheric
extinction coefficients in the band (approximately 700-900 nm),
and presented here are the derived atmospheric extinction coefficients from
each site over the years 1984 to 2016.Comment: 15 pages, 10 figures, 4 tables. Accepted by Astronomical Journal:
2017 July 2
Wideband Electrically Controlled Vernier Frequency Tunable Terahertz Quantum Cascade Laser
Frequency tuning in terahertz frequency quantum cascade lasers is challenging because of low thermal and current tuning coefficients. Moreover, photonic designs like Vernier selection based sampled gratings, used in telecom lasers to tune emission frequency, are unsuitable due to the long terahertz wavelengths and will require impractically long cavities (>15 mm). Here, we report the first wideband frequency tuning from a monolithic device exploiting Vernier selection rules using a coupled-cavity laser with a defect engineered photonic lattice. A precisely positioned defect lattice allows us to engineer the free spectral range and finesse of one of the cavities, similar to a sampled grating but using shorter cavity lengths (<4 mm). A coupled-cavity was used to tune the emission frequency. We achieve frequency tuning over 209 GHz, including mode hop-free continuous tuning of ∼6–21 GHz across six frequency bands, controlled through Stark shift, cavity-pulling, localized Joule heating, and thermal effects
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