New limits on "odderon" amplitudes from analyticity constraints

In studies of high energy $pp$ and $\bar pp$ scattering, the odd (under crossing) forward scattering amplitude accounts for the difference between the $pp$ and $\bar pp$ cross sections. Typically, it is taken as $f_-=-\frac{p}{4\pi}Ds^{\alpha-1}e^{i\pi(1-\alpha)/2}$ ($\alpha\sim 0.5$), which has $\Delta\sigma, \Delta\rho\to0$ as $s\to\infty$, where $\rho$ is the ratio of the real to the imaginary portion of the forward scattering amplitude. However, the odd-signatured amplitude can have in principle a strikingly different behavior, ranging from having $\Delta\sigma\to$non-zero constant to having $\Delta\sigma \to \ln s/s_0$ as $s\to\infty$, the maximal behavior allowed by analyticity and the Froissart bound. We reanalyze high energy $pp$ and $\bar pp$ scattering data, using new analyticity constraints, in order to put new and precise limits on the magnitude of ``odderon'' amplitudes.Comment: 13 pages LaTex, 6 figure

Photochemically Mediated Ring Expansion of Indoles and Pyrroles with Chlorodiazirines: Synthetic Methodology and Thermal Hazard Assessment

We demonstrate that arylchlorodiazirines serve as photo-activated halocarbene precursors for the selective one-carbon ring expansion of N-substituted pyrroles and indoles to the corresponding pyridinium and quinolinium salts. Preliminary investigations indicate that the same strategy also enables the conversion of N-substituted pyrazoles to pyrimidinium salts. The N-substituent of the substrate plays an essential role in: (1) increasing substrate scope by preventing product degradation, (2) enhancing yields by suppressing co-product inhibition, and (3) activating the azinium products towards subsequent synthetic manipulations. This latter point is illustrated by subjecting the quinolinium salts to four complementary partial reductions, which provide concise access to ring-expanded products with different degrees of increased C(sp3) character. Thermal analysis of the diazirines by differential scanning calorimetry (DSC) provides detailed insight into their energetic properties, and highlights the safety benefits of photolyzing—rather than thermolyzing—these reagents

Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity.

Circadian rhythms persist in almost all organisms and are crucial for maintaining appropriate timing in physiology and behaviour. Here, we describe a mouse mutant where the central mammalian pacemaker, the suprachiasmatic nucleus (SCN), has been genetically ablated by conditional deletion of the transcription factor Zfhx3 in the developing hypothalamus. Mutants were arrhythmic over the light-dark cycle and in constant darkness. Moreover, rhythms of metabolic parameters were ablated in vivo although molecular oscillations in the liver maintained some rhythmicity. Despite disruptions to SCN cell identity and circuitry, mutants could still anticipate food availability, yet other zeitgebers - including social cues from cage-mates - were ineffective in restoring rhythmicity although activity levels in mutants were altered. This work highlights a critical role for Zfhx3 in the development of a functional SCN, while its genetic ablation further defines the contribution of SCN circuitry in orchestrating physiological and behavioral responses to environmental signals

Gene-based mapping of trehalose biosynthetic pathway genes reveals association with source- and sink-related yield traits in a spring wheat panel

Trehalose 6-phosphate (T6P) signalling regulates carbon use and allocation and is a target to improve crop yields. However, the specific contributions of trehalose phosphate synthase (TPS) and trehalose phosphate phosphatase (TPP) genes to source- and sink-related traits remain largely unknown. We used enrichment-capture sequencing on TPS and TPP genes to estimate and partition the genetic variation of yield-related traits in a spring wheat (Triticum aestivum) breeding panel specifically built to capture the diversity across the 75,000 CIMMYT wheat cultivar collection. Twelve phenotypes were correlated to variation in TPS and TPP genes including plant height and biomass (source), spikelets per spike, spike growth, and grain filling traits (sink) which showed indications of both positive and negative gene selection. Individual genes explained proportions of heritability for biomass and grain-related traits. Three TPS1 homeologues were particularly significant for trait variation. Epistatic interactions were found within and between the TPS and TPP gene families for both plant height and grain-related traits. Gene-based prediction improved predictive ability for grain weight when gene effects were combined with the whole-genome markers. Our study has generated a wealth of information on natural variation of TPS and TPP genes related to yield potential which confirms the role for T6P in resource allocation and in affecting traits such as grain number and size confirming other studies which now opens up the possibility of harnessing natural genetic variation more widely to better understand the contribution of native genes to yield traits for incorporation into breeding programmes

XIM: X-Ray Inspection Module for Automatic High Speed Inspection of Turbine Blades and Automated Flaw Detection and Classification

Under military manufacturing technology funding, a production prototype X-ray Inspection Module (XIM) has been established at General Electric Corporate Research and Development (GE-CRD) and delivered to Quality Technology (QT), General Electric Aircraft Engine Business Group (GE-AEBG). A company funded production unit has been built by GE-AEBG and delivered to the GE-AEBG manufacturing facility in Madisonville, Kentucky where it is in use in production. Computerized tomography (CT) and digital fluoroscopy (DF) images are produced with the system. The CT images provide an image cross-section, and the DF images are much like chest X-rays.The system was designed to automatically inspect and analyze flaws present in turbine blades. It was applied to two flaw types; each type in a different turbine blade. The image processing is performed on complex gray scale images with varying background. The XIM system may be used either automatically or in a manual mode with a trained operator to interpret the images and make quality decisions

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

[This corrects the article DOI: 10.1038/s42003-018-0226-0.]

The spin dependence of high energy proton scattering

Motivated by the need for an absolute polarimeter to determine the beam polarization for the forthcoming RHIC spin program, we study the spin dependence of the proton-proton elastic scattering amplitudes at high energy and small momentum transfer.We examine experimental evidence for the existence of an asymptotic part of the helicity-flip amplitude phi_5 which is not negligible relative to the largely imaginary average non-flip amplitude phi_+. We discuss theoretical estimates of r_5, essentially the ratio of phi_5 to phi_+, based upon extrapolation of low and medium energy Regge phenomenological results to high energies, models based on a hybrid of perturbative QCD and non-relativistic quark models, and models based on eikonalization techniques. We also apply the model-independent methods of analyticity and unitarity.The preponderence of evidence at available energy indicates that r_5 is small, probably less than 10%. The best available experimental limit comes from Fermilab E704:those data indicate that |r_5|<15%. These bounds are important because rigorous methods allow much larger values. In contradiction to a widely-held prejudice that r_5 decreases with energy, general principles allow it to grow as fast as ln(s) asymptotically, and some models show an even faster growth in the RHIC range. One needs a more precise measurement of r_5 or to bound it to be smaller than 5% in order to use the classical Coulomb-nuclear interference technique for RHIC polarimetry. As part of this study, we demonstrate the surprising result that proton-proton elastic scattering is self-analysing, in the sense that all the helicity amplitudes can, in principle, be determined experimentally at small momentum transfer without a knowledge of the magnitude of the beam and target polarization

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing

Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we combine low-coverage (0.15×) sequencing with a new method to impute the ancestral haplotype space in 1,887 commercially available outbred mice. We mapped 156 unique quantitative trait loci for 92 phenotypes at a 5% false discovery rate. Gene-level mapping resolution was achieved at about one-fifth of the loci, implicating Unc13c and Pgc1a at loci for the quality of sleep, Adarb2 for home cage activity, Rtkn2 for intensity of reaction to startle, Bmp2 for wound healing, Il15 and Id2 for several T cell measures and Prkca for bone mineral content. These findings have implications for diverse areas of mammalian biology and demonstrate how genome-wide association studies can be extended via low-coverage sequencing to species with highly recombinant outbred populations

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function