Additional file 2: of Differentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer

Figure S1. A Manhattan plot showing all individual CpG sites and their p values. Figure S2A-P. Differences in beta-value between pre- and post-transplant samples per patient all DMRs. The different dots represent the individual CpG sites within the DMR. Figure S3A-P. CpG sites within each region that differ more than 0.05 in beta-value, colored per patient. The y-axis shows beta-value and the x-axis time in years after transplantation. Time points after transplantation are clustered in 0–1 years (N = 3), 1–3 years (N = 3), 3–5 years (N = 2) and 5+ years (N = 3). (DOCX 2008 kb

Additional file 1: of Differentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer

Table S1. Sequences of the PCR and sequence primers, amplicon sizes and PCR programs used for the technical validation. (PDF 548 kb

Broadening spectrum of bovine spongiform encephalopathies

Until recently the etiology of bovine spongiform encephalopathy (BSE) was considered uniform. The infectious agent was thought to be a single strain of prion (posttranslationally altered form of normal prion protein: PrPSc) retaining its biochemical and biological characteristics during interspecies transmission. However, alternate PrPSc signatures through large-scale screening have recently been detected. In addition, genetic alterations governing susceptibility to prion infection and a mutation (E211K) capable of eliciting spontaneous BSE have been demonstrated. Thus, the spectrum of BSEs have broadened and three PrPSc variants (BSE-C, BSE-H and BSE-L) are now defined. Moreover, a new condition resembling BSE, idiopathic brainstem neuronal chromatolysis (IBNC), has been described that may also turn out to be a prion disease. Since one of the new BSE variants, L-type BSE, proved highly pathogenic detection and further characterization of the new conditions are essential

Additional file 1: Figure S1. of The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

The mean proportion of the leukocyte fractions in the buffy coat samples collected before and after intervention with folic acid and vitamin B12 (n=44) or placebo (n=43). Estimates of the leukocyte fractions were based on the Houseman method

Additional file 3: Table S2a and S2b. of The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

Differentially methylated positions and regions related to serum levels of folate, vitamin B12 of plasma homocysteine. Overview of the top-10 of a) differentially methylated positions as well as b) regions related to serum levels of folate, vitamin B12 of plasma homocysteine

Additional file 2: Table S1. of The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

Top-100 positions that are differentially methylated after intervention with folic acid and vitamin B12. Overview of the top-100 positions that are differentially methylated (Benjamini-Hochberg adjusted p-value <0.05) after intervention with folic acid and vitamin B12 (FA/vB12). Changes for DNA methylation in the intervention group as well as the placebo group are presented as % beta-values and can range from 0-100 %

Additional file 9: of Blood lipids influence DNA methylation in circulating cells

Comparison between EWAS and MR estimates (with 95 % confidence intervals). (PDF 109 kb

Additional file 7: of Blood lipids influence DNA methylation in circulating cells

The HDL-C PS is nominally associated with confounder neutrophil counts. (CSV 202 bytes

Additional file 7: of Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

a Correlation between DNA methylation and gene expression of PcG complex proteins. b Overlap between genes associated in cis and in trans with the transcriptome clock [37]. (TIF 531 kb

Intervention dans le Podcast les Arts du FLE pour faire le point sur la perspective actionnelle en classe de langues

Ce podcast est disponible en ligne, à l'adresse suivante :https://agi.to/podcast/arts-du-fle-08-actionne-ton-approche/Ce numéro 8 des Arts du FLE (émission spécialisée en FLE) propose un dossier spécial approches pédagogiques et perspective actionnelle. J'en suis l'invitée et j'y réponds de manière détaillée pendant près d'une heure aux questions de l'animateur et créateur de ce Podcast, Sébastien Durietz (en poste actuellement à l'ONU, à New-York)