Oh! Doctor

https://digitalcommons.library.umaine.edu/mmb-vp/2285/thumbnail.jp

I Found The Sweetest Rose That Grows In Dixieland

Photo of young man; Illustration of lady picking flowershttps://scholarsjunction.msstate.edu/cht-sheet-music/1382/thumbnail.jp

If I Knew You Then As I Know You Now

No cover arthttps://scholarsjunction.msstate.edu/cht-sheet-music/9189/thumbnail.jp

Understanding The Lived Experiences of Black Female College Athletes and Factors that Influence their Anxiety.

To inform the development of culturally and socially appropriate interventions, this study examined the lived experiences of Black female college athletes (BFCA) and identified sources that increase their vulnerability to anxiety. Black Feminist Thought, with sub-tenets of intersectionality and outsider within status, was used as the theoretical foundation to examine the lives of the BFCA. Using an interpretative phenomenological approach, this qualitative study addressed the question: What sociocultural factors affect anxiety in Black female college athletes? Nine Black female college athletes from an NCAA Division I program agreed to participate in this study. Regarding the sources of anxiety, four themes emerged: regimented schedule (subthemes: lack of freedom, decreased choices, and external locus), forced community (subthemes: isolation and team conflict), emphasis on athletics (subthemes: coaching pressures, training pressures, and academic pressures) and navigating marginalization (subthemes: gender & racial stereotypes and gender & racial inequality). Two unexpected themes also materialized: family support and suggested solutions (subthemes: representation and communication). The findings and analysis were based on the data collected and the theoretical lens. The results suggest the need for culturally appropriate interventions to support this specific college athlete population

Effect of random on-site energies on the critical temperature of a lattice Bose gas

We study the effect of random on-site energies on the critical temperature of a non-interacting Bose gas on a lattice. In our derivation the on-site energies are distributed according a Gaussian probability distribution function having vanishing average and variance $v_o^2$. By using the replicated action obtained by averaging on the disorder, we perform a perturbative expansion for the Green functions of the disordered system. We evaluate the shift of the chemical potential induced by the disorder and we compute, for $v_o^2 << 1$, the critical temperature for condensation. We find that, for large filling, disorder slightly enhances the critical temperature for condensation.Comment: To appear in Laser Physics, issue on the LPHYS'08 conference (Trondheim, 2008

EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials

At a meeting of the EU/US/Clinical Trials in Alzheimer’s Disease (CTAD) Task Force in December 2016, an international group of investigators from industry, academia, and regulatory agencies reviewed lessons learned from ongoing and planned prevention trials, which will help guide future clinical trials of AD treatments, particularly in the pre-clinical space. The Task Force discussed challenges that need to be addressed across all aspects of clinical trials, calling for innovation in recruitment and retention, infrastructure development, and the selection of outcome measures. While cognitive change provides a marker of disease progression across the disease continuum, there remains a need to identify the optimal assessment tools that provide clinically meaningful endpoints. Patient- and informant-reported assessments of cognition and function may be useful but present additional challenges. Imaging and other biomarkers are also essential to maximize the efficiency of and the information learned from clinical trials

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

Assessing Philippine stock market integration: Evidences from the 2008 credit crisis

The paper aims to assess the existence of integration between the Philippine stock market and the ASEAN 5+3 and US stock markets. The researchers used both daily and weekly closing stock price indices of all nine (9) countries from January 2000 to January 2010. Testing will be done for the full sample and for two (2) periods, namely the pre crisis (2000-2007) and crisis period (2008-2010), to show the effect of the 2008 credit crisis in the degree of integration among the countries. Using the Johansen and Julius vector error correction model (VECM) approach, the researchers were able to verify that almost all stock markets, except for China and Thailand, influence the long run relationship among stock price indices for the full daily data. Compared to its developing neighbors, the Philippines is adversely affected by well-developed markets such as US, Japan and Singapore. Furthermore, during the crisis, more variable contributed to the long run equilibrium of the stock markets and that the speed of adjustment coefficients became faster implying that the crisis strengthened the degree of integration among stock markets. The weekly samples showed a similar result with daily data but with greater magnitude providing stronger speed of adjustments and more volatile impulse responses and variance decomposition. The paper concludes that the Philippines is integrated with the other markets tested with the recent credit crisis strengthening the integration process. The Philippine\u27s close stock market ties with developed economies also makes it more feasible for it to integrate with regional markets to achieve financial stability