10 research outputs found
The state of logistics in South Africa - perspectives from research
- Publication venue
- Document Transformation Technologies
- Publication date
- 06/07/2009
- Field of study
Paper presented at the 28th Annual Southern African Transport Conference 6 - 9 July 2009 "Sustainable Transport", CSIR International Convention Centre, Pretoria, South Africa.The purpose of this research was to measure the cost of Logistics In South Africa, determine the major cost drivers and assist both the country to manage those drivers and logist clans to manage logistics in this context. The measurement is on an industry and national level and can therefore
relate logistics Input with GDP as well as with industry-level turnover. A quantitative approach, based on a gravity-orientated freight flow model, road transport cost model, real transport costs for other modes, warehousing cost survey and inventory delay calculation for the economy, is followed.The overarching outcome is logistics cost measurement in an extended and detailed model, backdated for five years to establish trends and cost drivers. This leads to specific items that can be considered by industry and managed by government. In the recent past the sensitivity of logistics costs to fuel and interest rates is disconcerting as both items are "administered costs on an industry level and even on a national level for economies relying on imported fuel to move freight over long transport distances.Logisticians manage inventory delay downward relentlessly, but the "Tragedy of the Commons"-effect is overlooked and trade-offs on a national and even industry level often not managed effectively. In contrast, collaboration does not only contribute to micro improvements, but could counter negative trends on a macro level. Eventually the tradeoffs between specialisation, growth and sustainability come into play. The relationship between energy optimisation and environmental consciousness is also illustrated and solutions suggested.This paper was transferred from the original CD ROM created for this conference. The material was published using Adobe Acrobat 8.0 Technology.
The original CD ROM was produced by Document Transformation Technologies Postal Address: PO Box 560 Irene 0062 South Africa. Tel.: +27 12 667 2074 Fax: +27 12 667 2766 E-mail: nigel@doctech URL: http://www.doctech.co.z
Androgen receptor expression in satellite cells of the neonatal levator ani
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
The impact of euthanasia and enucleation on mouse corneal epithelial axon density and nerve terminal morphology
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The role of cell death in sexually dimorphic muscle development: Male-specific muscles are retained in female bax
- Author
- Breedlove
- Breedlove
- Cihak
- Cihak
- de Torres
- Dobrowolny
- Dominov
- Dominov
- Forger
- Forger
- Girgenrath
- Jacob
- Johansen
- Jordan
- Joubert
- Joubert
- Karacan
- Lindsten
- Lino
- Merry
- Miller
- Miyagoe
- Niel
- Nishikawa
- Pramatarova
- Rand
- Sachs
- Sachs
- Sachs
- Schroder
- Schultz
- Schwartz
- Sengelaub
- Soileau
- Sun
- Tobin
- Tobin
- Trachtenberg
- Ueyama
- Ulibarri
- Uo
- Varela
- Venable
- Wainman
- Wallach
- Wee
- Wei
- White
- Publication venue
- 'Wiley'
- Publication date
- Field of study
LIP Woordfeeskoerant 2010
- Author
- Beukes Mari
- Calitz Willemien
- Engel Rozanne
- Esterhuizen Jean
- Ferreira Louise
- Gava Chivimbiso
- Geldenhuys Nikita
- Gertenbach Luke
- Geyer Marisa
- Joubert Niel
- Kgatle Moipone
- Mannya Maphuti
- Matthysen Lynne
- McCain Nicole
- Miller George
- Moolman Renate
- Pienaar Loren
- Scholtz Hein
- Smeets Vanessa
- Strydom Casper
- Swartz Lize
- Theron Nadine
- Tighy Melissa
- Van Biljon Reinhard
- Van der Berg Willem
- Von Benecke Gerda
- Publication venue
- Stellenbosch : University of Stellenbosch
- Publication date
- 01/01/2010
- Field of study
The LIP Woordfeeskoerant is an independent Woordfees festival newspaper
produced by the BPhil (Journalism) class of that specific year in the Department of Journalism, Stellenbosch University.The LIP Woordfeeskoerant is an independent Woordfees festival newspaper
produced by the BPhil (Journalism) class of that specific year in the Department of Journalism, Stellenbosch University
Ăcologie industrielle, Ă©conomie de la fonctionnalitĂ©
- Author
- Adoue Cyril
- Bahers Jean-Baptiste
- Barles Sabine
- Beaurain Christophe
- Binninger Anne-Sophie
- Boutonné Antoine
- Brullot Sabrina
- Buclet Nicolas
- Carnoye Leslie
- Cazals Clarisse
- Cerceau Juliette
- DeldrÚve Valérie
- FiguiĂšre Catherine
- Georgeault Laurent
- Gonzalez Catherine
- Joubert Jérémie
- Junqua Guillaume
- Laforest Valérie
- Lipovac Jean-Christophe
- Lopez-Ferber Miguel
- Maillefert Muriel
- Metereau Renaud
- Niel Johan Van
- Norrant-Romand Caroline
- Ourahmoune Nacima
- Pouchain Delphine
- Robert Isabelle
- Theys Jacques
- Varlet Delphine
- Zaoual Anne-Rysléne
- Publication venue
- 'OpenEdition'
- Publication date
- 04/02/2014
- Field of study
What Role for the EU in the Southern African Customs Union (SACU): Advocate, Cajoler, or Bully?
- Author
- Af Reuters
- Af Reuters
- African National Congress
- Alexander Thompson
- Arne Tostensen
- Bosch Van Den
- Bosch Van Den
- Brigitte Weidlich
- Bueno De Mesquita
- Calle Schlettwein
- Calle Schlettwein
- Christy Van Der Merwe
- Christy Van Der Merwe
- Colin Mccarthy
- Curtis A Bradley
- Daniel L Nielson
- Desie Heita
- Desie Heita
- Europe Africa
- European Communities
- Festus Mogae
- Gerhard Erasmus
- Hancock
- Ibid
- James J Hentz
- Kathleen J Hancock
- Kathleen J. Hancock
- Lolette Kritzinger-Van Niekerk
- Loyiso Langeni
- Loyiso Langeni
- Mareike Meyn
- Mark A Pollack
- Mbongeni Mguni
- Mbongeni Mguni
- Michael J Tierney
- Mose Tjitendero
- Mthunzi Maziya
- Mzwandile Jacks
- Mzwandile Jacks
- Nick Martindale
- Niel Joubert
- Palolla Lehloenya
- Paul Kalenga
- Paul Kalenga
- Peter
- Prof Malema
- Prof Malema
- Richard Gibb
- Robert Davies
- Robert Kirk
- Ronald Hyam
- Sean Woolfrey
- Sean Woolfrey
- Servaas Van Den
- Sifiso Ngwenya
- Stephen Ettinger
- Tanja A Bïżœrzel
- Tanja A Bïżœrzel
- Teetee Zwane
- Terry M Moe
- U S
- Walter Mattli
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Facile Epoxidation Strategy for Producing Amphiphilic Up-Converting Rare-Earth Nanophosphors as Biological Labels
- Author
- Aldana J.
- Auzel F.
- Beaurepaire E.
- Bentzen E. L.
- Boyer J. C.
- Bruchez M.
- Burgos C. E.
- Cai W. B.
- Cai W. B.
- Chan W. C. W.
- Chatterjee D. K.
- Chen Z. G.
- Corstjens P. L. A. M.
- Denk W.
- Dubertret B.
- Ehlert O.
- Fan H.
- Findley T. W.
- Fujioka H.
- Gelb L.
- Heer S.
- Holland G. P.
- Ji X. H.
- Joubert M. F.
- Lahoz F.
- Lahoz F.
- Larson D. R.
- Lezhnina M. M.
- Li Z. Q.
- Lim S. F.
- Mack C. H.
- Mai H. X.
- Maiti S.
- Meiser F.
- Michalet X.
- Mori S.
- Niel G.
- Palmer R. J.
- Rieter W. J.
- Sachleben J. R.
- Sertchook H.
- Sivakumar S.
- Sivakumar S.
- Suyver J. F.
- Van de Rijke F.
- Wang F.
- Wang F.
- Wang L. Y.
- Wang L. Y.
- Wang X.
- Wang X.
- Yadav J. S.
- Yi G. S.
- Yi G. S.
- Yi G. S.
- Zhang P.
- Zhang P.
- Zhelev Z.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Chronic coronary syndromes without standard modifiable cardiovascular risk factors and outcomes: the CLARIFY registry
- Author
- AbardĂa Oliva F J
- Abdel Malak S
- Abdel Wahab H
- Abdul Kareem B B
- Abdul Rahim A A
- Abdul Wahab M Z
- Abdulkader Fuad
- Abdullah A S
- Abdullah C K
- Abduvalieva V
- Abele S
- Aboyans V
- Abtan Jérémie
- Achilli A
- Adam M
- Adamaszek K
- Adamczyk D
- Adamkiewicz A
- Adda M
- Aftab A
- Agrawal A
- Aguar Carrascosa P
- Aguiar C
- Ahuad Guerrero A
- Ahuja R
- Aimouch N
- Aiyegbayo O
- Ajani A
- Akbar M
- Aksyutina N
- Al Mahmeed Wael
- Al Rashdan Ibrahim
- Al Suwaidi Jassim
- Al B
- Al M
- Al-Becker H
- Al-Zaibag Muayed
- Alam A
- Alanazy M
- Alanbaei M
- Albero MartĂnez V
- Albuquerque A
- Alcaravela J
- Alcocer Gamba M
- Alegret Colomer J M
- AlegrĂa Ezquerra E
- Alekseenko V
- Alekseeva T
- Alexanderson E
- Alexopoulos I
- AlFaleh H
- Alford K
- Alhabib K F
- Alitto F
- Alizon F
- Allcock A
- Almeida FernĂĄndez C A
- Altevogt B-M
- Altmann U
- Alvarenga Recalde N
- Alvarez Auñon A
- Alvarez GarcĂa P
- Alves Costa M
- Alves C
- Amiel Oster Sauvinet G
- Amini R
- Amlaiky A
- Amo FernĂĄndez C
- Amor R
- Amoretti R
- Amoros Galito C
- Anastasiou E
- Ancliff H
- AncĂn Viguiristi R
- Andersen L K
- Andreev E
- Andreicheva E
- Andrews M
- Andrews M
- Ang C C
- Angela R
- Anghel M
- Ansalone G
- Anscombe M
- Antia V
- Antoniadis G A
- Antonicelli R
- Antunes J
- Aparici Feal M
- Appeltants H
- Arabadzhi N
- Arafah M
- Arden C
- Ardiaca Capell A
- Ardill J
- Ardouin L
- Arenas LeĂłn J L
- Arfaras V
- Arias Mendoza A
- Arkhipova Y
- Arnau M A
- Arnedillo Pardo J
- Arquero GarcĂa G
- Arrarte Esteban V
- Arroja I
- Arsenescu Georgescu C
- Arsentieva T
- Ashford A
- Ashmak K
- Ashton T H
- Asplanato M
- Assouline S
- Astrakhantseva P
- Astridge P
- Atamanchuk N
- Attia G
- Atueva K
- Aubry J
- Audibert H
- Augarde R
- Auhser F
- Aumjaud A
- Avgerinos C
- Avlonitis S
- Awtar Singh J S
- Ayche M
- Aylward P
- Azzolini P
- Baar M
- Babes K
- Baboshina N
- Bachmann B
- BadarienÄ J
- Badr-Eslam R
- Bahal A
- Baika A
- Bajcsi Ă
- Bakbak A I
- Balai R
- Balbi M
- Baleeva L
- BaleĂłn R
- Balice M A
- Ballet A
- Balogh G
- Banach J
- Banham S
- Banikova A
- Banu M
- Baptista S
- Baquero Alonso M
- Barahona PĂ©rez P
- Baranes C
- Baranova O
- BarauskienÄ G
- Bardachenko L
- BardajĂMayor J L
- Bariaud M
- Baril J F
- Barjhoux C
- Baroudi R
- Barrera Bustillos M
- Barriales Alvarez V
- Barron G
- Basara M
- Bashkirtcev O
- Baslaib F
- Bastian B
- Basto L
- Batalla Celorio A
- Bateman A
- Bates F
- Bath P S
- Batushkin V
- Baurenski L
- Bautista LĂłpez G
- Baverstock M
- Bayakhchan L
- Baylac Domengetroy F
- Bazargani N
- Bdeir M
- Beacock D
- Beale G
- Beaurain C
- Beinhauer A
- Belanger A
- Belcastro F
- Bell J
- Beltrame J F
- Benacka J
- Benett I
- Bennouna M A
- Berdnik K
- Berezhna T
- Berkenboom G
- Berlingieri J
- Bernard A
- Bernard X
- Bernardeau C
- Bernasconi F
- Berrisch S
- Berry P
- Bertarini J A
- Berthezene P
- Berzal MartĂn B
- Better N
- Beyer R
- Bhaskaran R K M
- Bhatt J S
- Bhayat J
- Bianco A
- Biausque F
- Bierge Valero D
- Bietzk R
- Bilous N
- Binet D
- Birkenhagen A
- Biryukova N
- Bishop P
- Bizyaeva N
- Blanc E
- Blanco Castiñeiras J
- Blignaut S
- Blindt R
- Blum I
- BlÀse I
- Bode G
- Bodur G
- Boesch C
- BogdaĆski P
- Boikova L
- Bokuchava N
- Bolidai A
- Bolotova N
- Bonal J
- Bondarenko B
- Bongo S
- Bonhomme R
- Bonnaud X
- Bonnet J L
- Bonnet P
- Bonny A
- Boonyapisit W
- Boonyasirinant T
- Borbola J
- Bories J
- Borodina N
- Bosa Ojeda F
- Bosch R
- Botana Penas C
- Bouchaya T
- Bourachot M L
- Bourazanis I
- Boureux C
- Bourgeois G
- Bourgeois J M
- Bousquet P
- Boutros G
- Boutsikos P
- Bouvy T
- Boyrazian H A
- Bozkova J
- Bradley J
- Bradshaw C
- Bragança G
- Brand N
- Bratishko I
- Brattström A
- Bratu I
- Breuer H-H
- Brice E
- Brindle P
- Briseño J L
- Brisson G
- Brodzicki P
- Brottier L
- Brouillette G
- Brown B
- Brown C
- Brown G
- Brown M
- Brown S
- Brownlie R
- Brscic E
- Brufau Redondo H
- Bruguera Cortada J
- Brumelot F
- Brunehaut Petaut M
- Brunner H
- Brunschwig C
- Bryl W
- Buakhamsri A
- Budanova I
- Buffet P
- Bui C M A
- Bui L
- Bui T T H
- Bukanina E
- Bulakhova E
- Bumbu A
- Bundy C
- Burgess L
- Burlakova L
- Burns R
- ButkuvienÄ I
- Bykovskaya S
- Byun Y S
- Bérubé J
- BĂŒttl A
- BĆaszczak P
- Cabrera Solé R
- Cahill T
- Calaça J
- Calder J
- Caldwell I
- Calmettes P
- Calvo Iglesias F
- Camossa C
- Campbell J
- Cantabrana Miguel S
- Capalneanu R
- Capuano N
- Carda J
- Caridi G
- Carpentier L
- Carpio R Cue
- Carretta D
- Carrillo Calvillo J
- Carrillo Cardoso R
- Carruthers T
- Carvalho De Moura B
- Carvalho J
- Carvalho R
- Casanovas Pié M
- Casas Giménez P
- Casas Juarezy U
- Castellari M
- Castillo Lueña E
- Castillo Moreno J A
- Castillo Orive M
- Castro A
- Castrucci M
- Catarino Carvalho M
- Cattan S
- Cavert B
- Cazenave C
- Centa I
- Ceraulo C
- Cerda Rojas J
- Cernetti C
- Cervenak R
- Ch'ng B S K
- Ch'ng E T
- Cha T J
- Chae I H
- Chaithiraphan V
- Chalkiadakis E
- Challenor V
- Cham Y L
- Chambel De Aguiar J
- Chamou K
- Chan B
- Chan K K
- Chan R
- Chan Y K
- Chandra S
- Chang B C
- Charikova O
- Charles H
- Chartier B
- Chatzioakim G
- Chau N H
- Chauhan N
- Cheah Y W
- Chee K H
- Chee T S
- Chehayeb R
- Chemin P
- Chen L L
- Chen M H
- Chen M Y
- Chen X P
- Chen Y D
- Cheng J
- Chenniappan M S
- Chernozemova A
- Cherry J M
- Chioncel O D
- Chirivella GonzĂĄlez A
- Chiscaneanu T
- Chlewicka I
- Choi H
- Chometon F
- Chonkar N S
- Choo G H
- Choor C K
- Chopo Alcubilla J M
- Choudhury P
- Chouinard G
- Christodorescu R
- Christoforidis C
- Chu C M
- Chua S K
- Chuang H H
- Chukwu A
- Chung A
- Chung E
- Chushak S
- Chyrek R
- ChĂĄvez Paez J
- Chételat C A
- Ciaroni S
- Cicek S
- Cierpka R
- Cieza Lara T A
- Cindea Nica N
- Cinteza M
- Cisowska E
- Claeys M
- Claus M
- Clavette P F
- Cleron S
- Clifford A
- Climent PayĂĄ V
- Cobos Gil M A
- Coetzee K
- Cohen J
- Coimbra S R
- Coimbra S R
- Colin R
- Colivicchi F
- Collette R S
- Colomer MartĂn J L
- Colquhoun D M
- Coman S
- Compson L
- ConcepciĂłn Clemente A
- Cong H L
- Conradie A
- Constance C
- Constantinescu M
- Conte M R
- Correia A
- Cortés Sånchez R
- Costa J
- Costello P
- Cotroneo J
- Cottin Y
- Counsell J T
- Cox S
- Craiu E
- Crawford L
- Cremer Luengo D
- Crespo F
- Cromarty I
- Cross D
- Cullen I
- Cunliffe G
- CustĂłdio M H
- Cygler J
- Czarnecka M
- Czarnecki W
- CzirĂĄki A
- Czuriga I
- CĂ©sar Luis Machado
- d'Alessandro V
- d'Este D
- Dabboura A
- Dalal J
- Dalampyras P
- Dalle Mule J
- Dalrymple J
- Dalton G
- Daly C
- Daly Kieran
- Dan A
- Dan D C
- Dan G A
- Danchin N
- Danchin Nicolas
- Dang L
- Dang V D
- Dang V P
- Daniel R
- Daniels E
- Darnes Soler S
- Dascotte Y
- Dau H
- David C M
- David F
- Davies E
- Davies R
- Davies S
- Davin L
- Davis R
- Davis R
- Davydova N
- Day B
- Dayani A
- Dayasagar Rao V
- de Andrés Novales J
- De Backer T
- de Brito Vianna C
- de Brito Vianna C
- De Castro Aritmendiz R
- De Geeter G
- de JesĂșs Rivera Arellano J
- de JeĂșs Zuñiga Sedano y America Alvarez J
- de Juan Baguda J
- de los Reyes LĂłpez M
- De Meester A
- De Niel C
- De Ridder S
- Dechoux E
- Dedkova S
- Dehayes P
- Deissner M
- Delcoulx E
- Delgado Prieto J L
- Delhomme C
- Dematteo P
- Demianiuk B
- Demina O
- Dendale P
- Denef K
- DereĆ M
- Dernedde C
- Detienne J P
- Dhanki M Al
- Dhesi A
- Di Pasquale P
- Dibon O
- Didier M
- Ding S F
- Dinh H N
- Dixon C
- Dixon S
- Dmitrieva N
- Dmitrieva T
- Do K B
- Do P A
- Do Q H
- Do T C
- Do T Q
- Do V C
- Doan V B
- Dodemant P
- Dominé F
- Donetti J
- Dong J T
- Dong S H
- DongĂł Ă
- Doohan M M
- Dookie T
- Dorian Paul
- Dormagen V
- Dorobantu M
- Doronzo B
- Doucet B
- Doucet J
- Dougall H
- Drexler M
- Dreycopp H
- Dreyfus X
- Drijfhout M
- Drozd J
- Drzewiecka A
- Du Plooy J
- Du Z M
- Dubinina E
- Dubinskaya R
- Dubois J M
- Dubrava J
- Dubs J P
- Duchowska R
- Duclos F
- Ducoudre M
- Ducrocq Grégory
- Dufka A
- Dunn J
- Duprez O
- Durand E
- Durand P
- Dutoya T
- Dymova D
- Dzhkha O
- Dzien A
- DĂaz DĂaz J L
- DĂaz JuĂĄrez R
- DĆŸenkeviÄiĆ«tÄ V
- Eavis P
- Eccleston D S
- Ecina V
- Edwards D
- Ege M
- Eggeling T
- Egido J
- Egloff P
- Egstrup K
- Eidelman S
- Eisele G
- El F
- Elbez Yedid
- Elias R
- Eliseeva N
- Elizondo Sifuentes L A
- Elkohen M
- Elkrail A
- Elliott V
- Ellis R
- Elsby K
- Emonts M
- Enayat D
- Engel R
- Ennouchi D
- Erglis Andrejs
- Erofeev S
- Escande M
- Escobar Cervantes C
- Escobedo de la Peña J
- Escourrou Berdou M C
- Esenokova A
- Esna Ashari G
- Esperon Guillermo Llamas
- Espiga De Macedo M
- Estrella J
- Estriga A
- Etcheverry B
- Everton Biglow C
- Evtukhova L
- Evéquoz D
- Ezcurdia Sasieta J
- Ezekiel D
- Facila Rubio L
- Fagan M
- Falces Salvador C
- Falconer H
- Fallacher M H
- Farcas D
- Farges J L
- Faria A
- Farto E Abreu P
- Fathi R
- Fauchier L
- Faudon B
- Fazekas F
- Fazil M A
- Federico Zaragoza P
- Fedorova N
- Fedoskin V
- Felbermayer M
- Feldman Laurent J
- Feldmann I
- Feldner-Busztin M
- Felice Castro Issa A
- Felice Castro Issa A
- Felis S
- Fellous F
- Feng L L
- Fernandes De Sousa F
- Fernandes A
- Fernandes F
- Fernandes F
- Fernandes J
- Fernandez Valadez E
- FernĂĄndez Alvarez R
- Fernåndez de la Cigoña F
- FernĂĄndez LĂĄzaro L A
- FernĂĄndez LĂ©oz L C
- FernĂĄndez Mouzo R
- FernĂĄndez-Valls GĂłmez M
- Ferrari Roberto
- Ferrari Roberto
- Ferreira Dos Santos J
- Ferreira J
- Ferreira P
- Ferreiro RodrĂguez B
- Ferreyra Solorio C
- Ferrieres J
- FerrĆo E Vasconcelos M F
- Fesenko T
- Fic M
- Fikker K
- Filip W
- Filippova E
- Fillet R
- Fillipova O
- Finlayson J
- Firastrau V
- Fitzgerald B
- Fleming S
- Flores J
- Florescu C
- Foltzer E
- Fong A Y Y
- Fonseca P F
- Fontanet B
- Forclaz A
- Ford Ian
- Ford J C
- Forge B H R
- Forrai R
- Forster T
- Forte De Carvalho J
- Foster E
- Fouquet G
- Fourchard V
- Fournier J B
- Fox Kim M
- Fraboulet J Y
- Franco Aranda C
- Frank U
- Frankiewicz A
- Franklin P
- Franskyavichene L
- Fras Z
- Fras Zlatko
- Frattola A
- Freeman V
- Freire Corzo J
- Freitas J
- Fressonnet R
- Frickel S
- Fridrich J
- Frost L
- Fuantos Delgado M L
- Fuertes Alonso J
- Fuertes Beneitez J
- Fullerton G M
- Furtak R
- Föchterle J
- Földi A
- Gabriilidis S
- GadziĆski W
- Gaglione A
- Galeeva Z
- Galehr E
- Galinier M
- Galve Basilio E
- Gamba Marco Alcocer
- Gamboa M C
- Gamzatov E
- Gao W
- Garandeau M
- Garaud Y
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- Zamorano José Luis
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- Ć lapikienÄ O B
- Publication venue
- Oxford University Press
- Publication date
- 20/05/2024
- Field of study
Background and Aims:
It has been reported that patients without standard modifiable cardiovascular (CV) risk factors (SMuRFsâdiabetes, dyslipidaemia, hypertension, and smoking) presenting with first myocardial infarction (MI), especially women, have a higher in-hospital mortality than patients with risk factors, and possibly a lower long-term risk provided they survive the post-infarct period. This study aims to explore the long-term outcomes of SMuRF-less patients with stable coronary artery disease (CAD).
Methods:
CLARIFY is an observational cohort of 32 703 outpatients with stable CAD enrolled between 2009 and 2010 in 45 countries. The baseline characteristics and clinical outcomes of patients with and without SMuRFs were compared. The primary outcome was a composite of 5-year CV death or non-fatal MI. Secondary outcomes were 5-year all-cause mortality and major adverse cardiovascular events (MACEâCV death, non-fatal MI, or non-fatal stroke).
Results:
Among 22 132 patients with complete risk factor and outcome information, 977 (4.4%) were SMuRF-less. Age, sex, and time since CAD diagnosis were similar across groups. SMuRF-less patients had a lower 5-year rate of CV death or non-fatal MI (5.43% [95% CI 4.08â7.19] vs. 7.68% [95% CI 7.30â8.08], P = 0.012), all-cause mortality, and MACE. Similar results were found after adjustments. Clinical event rates increased steadily with the number of SMuRFs. The benefit of SMuRF-less status was particularly pronounced in women.
Conclusions:
SMuRF-less patients with stable CAD have a substantial but significantly lower 5-year rate of CV death or non-fatal MI than patients with risk factors. The risk of CV outcomes increases steadily with the number of risk factors