10 research outputs found
Plan istraživanja praznih artefakata na poslijeoperacijskim nalazima magnetne rezonance dojke nakon primjene superparamagnetiÄnog željeznog oksida u biopsiji limfng Ävora stražara
Sentinel lymph node biopsy (SLNB) is the gold standard in surgical treatment of early-stage breast cancer. Since June 2015 we have been performing SLNB in our hospital with a new technique which uses superparamagnetic iron oxide (SPIO), commercially known as Sienna+, as tracer and device-magnetometer (SentiMag) for locating axillary lymph nodes which accumulated SPIO particles. Artifacts resulting from SPIO accumulation in the breast tissue were observed on post-operative breast magnetic resonace imaging (MRI) scans in all patients who underwent postoperative breast MRIs. Artifacts were
observed on T1-weighted images, as well as on dynamic and subtraction sequences. We have designed a study that will include a three-year post-operative follow-up of these patients with MRI breast scans in order to evaluate presence or absence of these artifacts and change of artifacts over time. Upon completion of the study indications for using magnetic SLNB may need to be revised.Biopsija limfnog Ävora stražara je zlatni standard u kirurÅ”kom lijeÄenju ranog stadija raka dojke. Od lipnja 2015. godine, u naÅ”oj ustanovi koristi se nova metoda obilježavanja superparamagnetiÄnim željeznim oksidom, komercijalnog imena Sienna+. Za pronalaženje limfnog Ävora s nakupljenim Äesticama željeznog oksida koristi se detektor ā SentiMag. Kod bolesnica kod kojih je uÄinjena poslijeoperacijska magnentna rezonanca dojki uoÄeni su artefakti na T1 mjerenim snimkama, a takoÄer i na dinamiÄkim i subtrakcijskim sekvencama. Osmislili smo studiju kojom Äe se tri godine magnetnom rezonancom pratiti operirane bolesnice. Odredit Äe se prisutnost artefakata, te njihova prisutnost tijekom vremenu. OÄekuju se nove
spoznaje korisne u biopsije limfnog Ävora stražara
Editorial to the Special issue
This special issue of Management ā Journal of Contemporary Management Issues features selected best papers, previously presented at the 14th International Scientific Conference āChallenges of Europe: Design for the Next Generation,ā organized by the Faculty of Economics, Business and Tourism, University of Split, Croatia. This is the largest conference in this part of Europe, with multiple Nobel Prize winners participating as invited speakers.
This issue consists of eight papers covering the topics of entrepreneurship, human resource management, project management education, career development, green policies and sustainability, agro-tourism management, and sharing economy, with a focus on Central, Eastern, and Southeast Europe
Botulin toxin A in lower lid entropium correction
To evaluate the clinical results and report the results of 12 cases of senile involutional entropion of the lower lid treated with botulinum toxi
Plan istraživanja praznih artefakata na poslijeoperacijskim nalazima magnetne rezonance dojke nakon primjene superparamagnetiÄnog željeznog oksida u biopsiji limfng Ävora stražara
Sentinel lymph node biopsy (SLNB) is the gold standard in surgical treatment of early-stage breast cancer. Since June 2015 we have been performing SLNB in our hospital with a new technique which uses superparamagnetic iron oxide (SPIO), commercially known as Sienna+, as tracer and device-magnetometer (SentiMag) for locating axillary lymph nodes which accumulated SPIO particles. Artifacts resulting from SPIO accumulation in the breast tissue were observed on post-operative breast magnetic resonace imaging (MRI) scans in all patients who underwent postoperative breast MRIs. Artifacts were
observed on T1-weighted images, as well as on dynamic and subtraction sequences. We have designed a study that will include a three-year post-operative follow-up of these patients with MRI breast scans in order to evaluate presence or absence of these artifacts and change of artifacts over time. Upon completion of the study indications for using magnetic SLNB may need to be revised.Biopsija limfnog Ävora stražara je zlatni standard u kirurÅ”kom lijeÄenju ranog stadija raka dojke. Od lipnja 2015. godine, u naÅ”oj ustanovi koristi se nova metoda obilježavanja superparamagnetiÄnim željeznim oksidom, komercijalnog imena Sienna+. Za pronalaženje limfnog Ävora s nakupljenim Äesticama željeznog oksida koristi se detektor ā SentiMag. Kod bolesnica kod kojih je uÄinjena poslijeoperacijska magnentna rezonanca dojki uoÄeni su artefakti na T1 mjerenim snimkama, a takoÄer i na dinamiÄkim i subtrakcijskim sekvencama. Osmislili smo studiju kojom Äe se tri godine magnetnom rezonancom pratiti operirane bolesnice. Odredit Äe se prisutnost artefakata, te njihova prisutnost tijekom vremenu. OÄekuju se nove
spoznaje korisne u biopsije limfnog Ävora stražara
Multiparametrijska magnetska rezonancija u procjeni karcinoma prostate
Multiparametric magnetic resonance is assuming an increasingly important role in the diagnosis, initial assessment and monitoring of patients with prostate cancer. This paper offers a more complex insight into the application of magnetic resonance imaging with prostate cancer, with a current literature overview. The focus is on the problem of initial prostate cancer evaluation which strongly affects further decision-making and therapeutic interventions. Clinical suggestions based on the current guidelines are also offered.Multiparametrijska magnetska rezonancija preuzima sve znaÄajniju ulogu u dijagnostici, inicijalnoj procjeni, kao i praÄenju pacijenata s karcinomom prostate. Ovaj rad nudi složeniji uvid u pitanje primjene magnetske rezonancije kod karcinoma prostate, uz pregled trenutne literature iz podruÄja. Posebno težiÅ”te je stavljeno na problem inicijalne procjene karcinoma prostate koje uvelike determinira daljnje odluÄivanje i terapijsko postupanje. PonuÄene su i preporuke temeljene na trenutnim smjernicama
Phase controlled rectifiers
Analiziranjem mosnog diodnog spoja zakljuÄuje se da sklop ispravlja punovalno ispravlja ulazni signal a rezultirani signal je dvostruko manjeg perioda od ulaznog signala i dvostruko veÄe frekvencije. Kod mosnog spoja sa samim omskim otporom dobiva se ispravljeni izlazni signal meÄutim takav oblik izlaznog signala je nepoželjan. Ako se želi postiÄi sklop sa boljim faktorom snage potrebno je paraleleno sa omskim troÅ”ilom spojiti kondenzator koji Äe izgladiti signal i poveÄati faktor snage. Fazno upravljivi sklopovi izlaznim signalom upravljaju pomoÄnim strujnim impulsom koji se dovodi na vrata SCR-a. Ovisno o kutu Ī± strujnog impulsa na izlazu se dobivaju razliÄiti naponski oblici. Teoretska analiza pokazuje da se za kut Ī± = 0 na izlazu dobiva maksimalna srednja vrijednost napona. Važno je naglasiti da u strujne krugove koji ukljuÄuju induktivna troÅ”ila treba dodati filtere signala kako bi se eliminirala neizbježna pojava viÅ”ih harmonika.Results of bridge diode rectifier analisys show that the effects of single phase full wave rectification on the output voltage are as follows: output voltage has its frequency doubled and period halved compared to input voltage. Different circuit loads yield different output voltages, while bridge rectifier with R load offers DC signal its waveform is far from useful in real life applications. Reason behind this is low power factor value which results with high energy losses in the circuit. Solution for this problem is addition of filter capacitors that smooth out the output signal and increase value of power factor. Phase controlled rectifiers are the next improvement from the diode bridge rectifier because the use of SCR allows control of the output signal. Output signal varies depending on the value of the delay angle Ī±. Maximum value of average output signal is achieved when Ī±=0Ā°. Lastly, it is important to emphasize the effect that inductive loads have on rectifier circuits. Inductive loads generate harmonics both in supply system as well as in load circuits so adding filters is inevitable
Role of Multiparametric Magnetic Resonance Imaging in Prostate Cancer Assessment
Multiparametric magnetic resonance is assuming an increasingly important role in the diagnosis, initial assessment and monitoring of patients with prostate cancer. This paper offers a more complex insight into the application of magnetic resonance imaging with prostate cancer, with a current literature overview. The focus is on the problem of initial prostate cancer evaluation which strongly affects further decision-making and therapeutic interventions. Clinical suggestions based on the current guidelines are also offered
Machine learning-based prediction of microsatellite instability and high tumor mutation burden from contrast-enhanced computed tomography in endometrial cancers
Abstract To evaluate whether radiomic features from contrast-enhanced computed tomography (CE-CT) can identify DNA mismatch repair deficient (MMR-D) and/or tumor mutational burden-high (TMB-H) endometrial cancers (ECs). Patients who underwent targeted massively parallel sequencing of primary ECs between 2014 and 2018 and preoperative CE-CT were included (nā=ā150). Molecular subtypes of EC were assigned using DNA polymerase epsilon (POLE) hotspot mutations and immunohistochemistry-based p53 and MMR protein expression. TMB was derived from sequencing, with >ā15.5 mutations-per-megabase as a cut-point to define TMB-H tumors. After radiomic feature extraction and selection, radiomic features and clinical variables were processed with the recursive feature elimination random forest classifier. Classification models constructed using the training dataset (nā=ā105) were then validated on the holdout test dataset (nā=ā45). Integrated radiomic-clinical classification distinguished MMR-D from copy number (CN)-low-like and CN-high-like ECs with an area under the receiver operating characteristic curve (AUROC) of 0.78 (95% CI 0.58ā0.91). The model further differentiated TMB-H from TMB-low (TMB-L) tumors with an AUROC of 0.87 (95% CI 0.73ā0.95). Peritumoral-rim radiomic features were most relevant to both classifications (pāā¤ā0.044). Radiomic analysis achieved moderate accuracy in identifying MMR-D and TMB-H ECs directly from CE-CT. Radiomics may provide an adjunct tool to molecular profiling, especially given its potential advantage in the setting of intratumor heterogeneity