Plan istraživanja praznih artefakata na poslijeoperacijskim nalazima magnetne rezonance dojke nakon primjene superparamagnetičnog željeznog oksida u biopsiji limfng čvora stražara

Sentinel lymph node biopsy (SLNB) is the gold standard in surgical treatment of early-stage breast cancer. Since June 2015 we have been performing SLNB in our hospital with a new technique which uses superparamagnetic iron oxide (SPIO), commercially known as Sienna+, as tracer and device-magnetometer (SentiMag) for locating axillary lymph nodes which accumulated SPIO particles. Artifacts resulting from SPIO accumulation in the breast tissue were observed on post-operative breast magnetic resonace imaging (MRI) scans in all patients who underwent postoperative breast MRIs. Artifacts were observed on T1-weighted images, as well as on dynamic and subtraction sequences. We have designed a study that will include a three-year post-operative follow-up of these patients with MRI breast scans in order to evaluate presence or absence of these artifacts and change of artifacts over time. Upon completion of the study indications for using magnetic SLNB may need to be revised.Biopsija limfnog čvora stražara je zlatni standard u kirurškom liječenju ranog stadija raka dojke. Od lipnja 2015. godine, u našoj ustanovi koristi se nova metoda obilježavanja superparamagnetičnim željeznim oksidom, komercijalnog imena Sienna+. Za pronalaženje limfnog čvora s nakupljenim česticama željeznog oksida koristi se detektor – SentiMag. Kod bolesnica kod kojih je učinjena poslijeoperacijska magnentna rezonanca dojki uočeni su artefakti na T1 mjerenim snimkama, a također i na dinamičkim i subtrakcijskim sekvencama. Osmislili smo studiju kojom će se tri godine magnetnom rezonancom pratiti operirane bolesnice. Odredit će se prisutnost artefakata, te njihova prisutnost tijekom vremenu. Očekuju se nove spoznaje korisne u biopsije limfnog čvora stražara

Editorial to the Special issue

This special issue of Management – Journal of Contemporary Management Issues features selected best papers, previously presented at the 14th International Scientific Conference “Challenges of Europe: Design for the Next Generation,” organized by the Faculty of Economics, Business and Tourism, University of Split, Croatia. This is the largest conference in this part of Europe, with multiple Nobel Prize winners participating as invited speakers. This issue consists of eight papers covering the topics of entrepreneurship, human resource management, project management education, career development, green policies and sustainability, agro-tourism management, and sharing economy, with a focus on Central, Eastern, and Southeast Europe

Botulin toxin A in lower lid entropium correction

To evaluate the clinical results and report the results of 12 cases of senile involutional entropion of the lower lid treated with botulinum toxi

Plan istraživanja praznih artefakata na poslijeoperacijskim nalazima magnetne rezonance dojke nakon primjene superparamagnetičnog željeznog oksida u biopsiji limfng čvora stražara

Sentinel lymph node biopsy (SLNB) is the gold standard in surgical treatment of early-stage breast cancer. Since June 2015 we have been performing SLNB in our hospital with a new technique which uses superparamagnetic iron oxide (SPIO), commercially known as Sienna+, as tracer and device-magnetometer (SentiMag) for locating axillary lymph nodes which accumulated SPIO particles. Artifacts resulting from SPIO accumulation in the breast tissue were observed on post-operative breast magnetic resonace imaging (MRI) scans in all patients who underwent postoperative breast MRIs. Artifacts were observed on T1-weighted images, as well as on dynamic and subtraction sequences. We have designed a study that will include a three-year post-operative follow-up of these patients with MRI breast scans in order to evaluate presence or absence of these artifacts and change of artifacts over time. Upon completion of the study indications for using magnetic SLNB may need to be revised.Biopsija limfnog čvora stražara je zlatni standard u kirurškom liječenju ranog stadija raka dojke. Od lipnja 2015. godine, u našoj ustanovi koristi se nova metoda obilježavanja superparamagnetičnim željeznim oksidom, komercijalnog imena Sienna+. Za pronalaženje limfnog čvora s nakupljenim česticama željeznog oksida koristi se detektor – SentiMag. Kod bolesnica kod kojih je učinjena poslijeoperacijska magnentna rezonanca dojki uočeni su artefakti na T1 mjerenim snimkama, a također i na dinamičkim i subtrakcijskim sekvencama. Osmislili smo studiju kojom će se tri godine magnetnom rezonancom pratiti operirane bolesnice. Odredit će se prisutnost artefakata, te njihova prisutnost tijekom vremenu. Očekuju se nove spoznaje korisne u biopsije limfnog čvora stražara

Multiparametrijska magnetska rezonancija u procjeni karcinoma prostate

Multiparametric magnetic resonance is assuming an increasingly important role in the diagnosis, initial assessment and monitoring of patients with prostate cancer. This paper offers a more complex insight into the application of magnetic resonance imaging with prostate cancer, with a current literature overview. The focus is on the problem of initial prostate cancer evaluation which strongly affects further decision-making and therapeutic interventions. Clinical suggestions based on the current guidelines are also offered.Multiparametrijska magnetska rezonancija preuzima sve značajniju ulogu u dijagnostici, inicijalnoj procjeni, kao i praćenju pacijenata s karcinomom prostate. Ovaj rad nudi složeniji uvid u pitanje primjene magnetske rezonancije kod karcinoma prostate, uz pregled trenutne literature iz područja. Posebno težište je stavljeno na problem inicijalne procjene karcinoma prostate koje uvelike determinira daljnje odlučivanje i terapijsko postupanje. Ponuđene su i preporuke temeljene na trenutnim smjernicama

Phase controlled rectifiers

Analiziranjem mosnog diodnog spoja zaključuje se da sklop ispravlja punovalno ispravlja ulazni signal a rezultirani signal je dvostruko manjeg perioda od ulaznog signala i dvostruko veće frekvencije. Kod mosnog spoja sa samim omskim otporom dobiva se ispravljeni izlazni signal međutim takav oblik izlaznog signala je nepoželjan. Ako se želi postići sklop sa boljim faktorom snage potrebno je paraleleno sa omskim trošilom spojiti kondenzator koji će izgladiti signal i povećati faktor snage. Fazno upravljivi sklopovi izlaznim signalom upravljaju pomoćnim strujnim impulsom koji se dovodi na vrata SCR-a. Ovisno o kutu α strujnog impulsa na izlazu se dobivaju različiti naponski oblici. Teoretska analiza pokazuje da se za kut α = 0 na izlazu dobiva maksimalna srednja vrijednost napona. Važno je naglasiti da u strujne krugove koji uključuju induktivna trošila treba dodati filtere signala kako bi se eliminirala neizbježna pojava viših harmonika.Results of bridge diode rectifier analisys show that the effects of single phase full wave rectification on the output voltage are as follows: output voltage has its frequency doubled and period halved compared to input voltage. Different circuit loads yield different output voltages, while bridge rectifier with R load offers DC signal its waveform is far from useful in real life applications. Reason behind this is low power factor value which results with high energy losses in the circuit. Solution for this problem is addition of filter capacitors that smooth out the output signal and increase value of power factor. Phase controlled rectifiers are the next improvement from the diode bridge rectifier because the use of SCR allows control of the output signal. Output signal varies depending on the value of the delay angle α. Maximum value of average output signal is achieved when α=0°. Lastly, it is important to emphasize the effect that inductive loads have on rectifier circuits. Inductive loads generate harmonics both in supply system as well as in load circuits so adding filters is inevitable

Role of Multiparametric Magnetic Resonance Imaging in Prostate Cancer Assessment

Multiparametric magnetic resonance is assuming an increasingly important role in the diagnosis, initial assessment and monitoring of patients with prostate cancer. This paper offers a more complex insight into the application of magnetic resonance imaging with prostate cancer, with a current literature overview. The focus is on the problem of initial prostate cancer evaluation which strongly affects further decision-making and therapeutic interventions. Clinical suggestions based on the current guidelines are also offered

Machine learning-based prediction of microsatellite instability and high tumor mutation burden from contrast-enhanced computed tomography in endometrial cancers

Abstract To evaluate whether radiomic features from contrast-enhanced computed tomography (CE-CT) can identify DNA mismatch repair deficient (MMR-D) and/or tumor mutational burden-high (TMB-H) endometrial cancers (ECs). Patients who underwent targeted massively parallel sequencing of primary ECs between 2014 and 2018 and preoperative CE-CT were included (n = 150). Molecular subtypes of EC were assigned using DNA polymerase epsilon (POLE) hotspot mutations and immunohistochemistry-based p53 and MMR protein expression. TMB was derived from sequencing, with > 15.5 mutations-per-megabase as a cut-point to define TMB-H tumors. After radiomic feature extraction and selection, radiomic features and clinical variables were processed with the recursive feature elimination random forest classifier. Classification models constructed using the training dataset (n = 105) were then validated on the holdout test dataset (n = 45). Integrated radiomic-clinical classification distinguished MMR-D from copy number (CN)-low-like and CN-high-like ECs with an area under the receiver operating characteristic curve (AUROC) of 0.78 (95% CI 0.58–0.91). The model further differentiated TMB-H from TMB-low (TMB-L) tumors with an AUROC of 0.87 (95% CI 0.73–0.95). Peritumoral-rim radiomic features were most relevant to both classifications (p ≤ 0.044). Radiomic analysis achieved moderate accuracy in identifying MMR-D and TMB-H ECs directly from CE-CT. Radiomics may provide an adjunct tool to molecular profiling, especially given its potential advantage in the setting of intratumor heterogeneity