19 research outputs found

    Concentration or representation : the struggle for popular sovereignty

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    There is a tension in the notion of popular sovereignty, and the notion of democracy associated with it, that is both older than our terms for these notions themselves and more fundamental than the apparently consensual way we tend to use them today. After a review of the competing conceptions of 'the people' that underlie two very different understandings of democracy, this article will defend what might be called a 'neo-Jacobin' commitment to popular sovereignty, understood as the formulation and imposition of a shared political will. A people's egalitarian capacity to concentrate both its collective intelligence and force, from this perspective, takes priority over concerns about how best to represent the full variety of positions and interests that differentiate and divide a community

    Additional file 6: Figure S1. of An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

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    SNP annotation and enrichment analysis in different types of functional data. Figure S2. A colon-specific TF-target gene regulatory network for inflammatory bowel disease. (PDF 1073 kb

    Additional file 1: of Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus

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    Table S1. Significant codes from the PheWAS of African Americans vs. Caucasians with SLE. Figure S1. Selected SLE disease criteria codes in the PheWAS of African Americans and Cauasians with SLE. Table S2. Selected SLE criteria codes from the PheWAS of African Americans and Caucasians with SLE. Table S3. Selected codes related to renal, cardiovascular disease, and infection from the PheWAS of African American SLE cases compared to matched African American controls. Table S4. Selected codes related to SLE criteria from the PheWAS of African American SLE cases and matched African American controls. Table S5. Selected codes from the PheWAS of Caucasian SLE cases compared to matched Caucasian controls. Table S6. Conditional logistic regression models with SLE cases and matched controls. (DOCX 134 kb

    Phenotypes and PheWAS of Individuals with Moderate-Severe Loxoscelism.

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    <p>(A) Manhattan plot representing the number of individuals with moderate to severe loxoscelism with each phenotype. The most frequent phenotypes validated the loxoscelism definition and included the toxic effect of venom, acquired hemolytic anemia, fever of unknown origin, and rash/skin eruption. (B) PheWAS for moderate-severe loxoscelism. The blue line represents significance level without correction (<i>p</i> = 0.05). The red line is representative of the adjusted significance threshold using the Bonferroni correction for multiple comparisons (<i>p =</i> 1.2 x 10<sup>−4</sup>). 29 phenotypes showed a significant correlation (p < 1.2 x 10<sup>−4</sup>) with the loxoscelism phenotype when compared to controls.</p
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