Evaluating the efficacy of tuberculosis advocacy, communication and social mobilization (ACSM) activities in Pakistan : a cross-sectional study

BACKGROUND: Tuberculosis (TB) continues to be a major public health and development problem within many low- and middle-income countries. Although Advocacy, Communication and Social Mobilization (ACSM) activities have been undertaken in high TB burden countries to remediate these issues, there is little empirical evidence of the efficacy of these approaches. The purpose of this study was therefore to examine the efficacy of an ACSM program undertaken within Pakistan. Pakistan was chosen because it has received considerable funding for ACSM related activities and is one of 22 high-burden TB countries. METHODS: The program was evaluated by surveying a stratified random sample of 2,400 participants across 57 districts of Pakistan. Participants were categorized into one of three groups: aware of both media and community ACSM activities (Aware(Media)&(Community)), aware of ACSM media activities only (Aware(Media)), or unaware of any ACSM activities (Unaware(Media)&(Community)). RESULTS: Independent measures ANCOVA revealed complex differences in knowledge, attitudes, and intended behaviors towards TB between the three groups. In general, Unaware(Media)&(Community) cases had a poorer understanding of TB and its treatment, whilst awareness of ACSM activities was highest among literate and urban dwelling Pakistanis. Preferred sources of TB information were also found to vary by gender, geographic location, and literacy. CONCLUSIONS: Whilst highlighting improvements in knowledge and attitudes toward TB, the results also provide invaluable insights into areas where further work needs to be done to address deficits in TB understanding, particularly among rural and illiterate Pakistanis. Equally important, the findings have implications for future TB ACSM initiatives in Pakistan in terms of leveraging the preferred media channels of key demographic segments and exploring the degree to which exposure to multiple channels of communication may have an additive effect on health knowledge

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.

Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the kinases that control inflammatory signaling, less is known about the opposing phosphatases. Here we report that deletion of the gene encoding PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) protects mice from lethal lipopolysaccharide (LPS) challenge and live Escherichia coli infection. Investigation of PHLPP1 function in macrophages reveals that it controls the magnitude and duration of inflammatory signaling by dephosphorylating the transcription factor STAT1 on Ser727 to inhibit its activity, reduce its promoter residency, and reduce the expression of target genes involved in innate immunity and cytokine signaling. This previously undescribed function of PHLPP1 depends on a bipartite nuclear localization signal in its unique N-terminal extension. Our data support a model in which nuclear PHLPP1 dephosphorylates STAT1 to control the magnitude and duration of inflammatory signaling in macrophages

The Response to a Perturbation in the Reflection Amplitude

We apply inverse scattering theory to calculate the functional derivative of the potential $V(x)$ and wave function $\psi(x,k)$ of a one-dimensional Schr\"odinger operator with respect to the reflection amplitude $r(k)$.Comment: 16 pages, no figure

When nutritional guidelines and life collide: family fruit and vegetable socialisation practices in low socioeconomic communities

Parents play a critical role in promoting fruit and vegetable consumption, for eating patterns established early in life tend to persist into adulthood. Despite this, the factors that facilitate or inhibit parents’ capacity to socialise fruit and vegetable consumption into their children’s daily diets remain poorly defined. Thirty-eight semi-structured interviews with residents, allied healthcare professionals, community leaders, community programme leaders and a local government leader living or working in two low socioeconomic suburbs were consequently conducted to ascertain factors exogenous and endogenous to the family unit that shaped parental food socialisation practices. Budgetary and time constraints emerged as exogenous factors that constrained fruit and vegetable socialisation. Constraining effects were also found for a range of endogenous factors, including commensal experiences, children’s food fussiness and the feeding styles employed by parents. As such, while many caregivers may wish to socialise fruit and vegetable consumption into their children’s daily diets, their capacity to do so is often inhibited by factors beyond their volitional control. Failure to take heed of these factors could therefore result in the development of social marketing campaigns that are ineffective at best or give rise to unintentionally harmful outcomes at worst

Is There a Fundamental Line for Disk Galaxies?

We show that there are strong local correlations between metallicity, surface brightness, and dynamical mass-to-light ratio within M33, analogous to the fundamental line of dwarf galaxies identified by Prada & Burkert (2002). Using near-infrared imaging from 2MASS, the published rotation curve of M33, and literature measurements of the metallicities of HII regions and supergiant stars, we demonstrate that these correlations hold for points at radial distances between 140 pc and 6.2 kpc from the center of the galaxy. At a given metallicity or surface brightness, M33 has a mass-to-light ratio approximately four times as large as the Local Group dwarf galaxies; other than this constant offset, we see broad agreement between the M33 and dwarf galaxy data. We use analytical arguments to show that at least two of the three fundamental line correlations are basic properties of disk galaxies that can be derived from very general assumptions. We investigate the effect of supernova feedback on the fundamental line with numerical models and conclude that while feedback clearly controls the scatter in the fundamental line, it is not needed to create the fundamental line itself, in agreement with our analytical calculations. We also compare the M33 data with measurements of a simulated disk galaxy, finding that the simulation reproduces the trends in the data correctly and matches the fundamental line, although the metallicity of the simulated galaxy is too high, and the surface brightness is lower than that of M33.Comment: 14 pages, 14 figures (5 in color). Accepted for publication in Ap

Characterizing K2 Candidate Planetary Systems Orbiting Low-mass Stars. I. Classifying Low-mass Host Stars Observed during Campaigns 1–7

We present near-infrared spectra for 144 candidate planetary systems identified during Campaigns 1–7 of the NASA K2 Mission. The goal of the survey was to characterize planets orbiting low-mass stars, but our Infrared Telescope Facility/SpeX and Palomar/TripleSpec spectroscopic observations revealed that 49% of our targets were actually giant stars or hotter dwarfs reddened by interstellar extinction. For the 72 stars with spectra consistent with classification as cool dwarfs (spectral types K3–M4), we refined their stellar properties by applying empirical relations based on stars with interferometric radius measurements. Although our revised temperatures are generally consistent with those reported in the Ecliptic Plane Input Catalog (EPIC), our revised stellar radii are typically 0.13 [subscript ⊙](39%) larger than the EPIC values, which were based on model isochrones that have been shown to underestimate the radii of cool dwarfs. Our improved stellar characterizations will enable more efficient prioritization of K2 targets for follow-up studies