Evidence for the Adverse Effect of Starvation on Bone Quality: A Review of the Literature

Malnutrition and starvation’s possible adverse impacts on bone health and bone quality first came into the spotlight after the horrors of the Holocaust and the ghettos of World War II. Famine and food restrictions led to a mean caloric intake of 200–800 calories a day in the ghettos and concentration camps, resulting in catabolysis and starvation of the inhabitants and prisoners. Severely increased risks of fracture, poor bone mineral density, and decreased cortical strength were noted in several case series and descriptive reports addressing the medical issues of these individuals. A severe effect of severely diminished food intake and frequently concomitant calcium- and Vitamin D deficiencies was subsequently proven in both animal models and the most common cause of starvation in developed countries is anorexia nervosa. This review attempts to summarize the literature available on the impact of the metabolic response to Starvation on overall bone health and bone quality

Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels

A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.National Institutes of Health (U.S.) (RO1 DE016516)National Institutes of Health (U.S.) (R01 EB000244)Damon Runyon Cancer Research Foundation (DFS-#2050-10

A Merged Catalog of Clusters of Galaxies from Early SDSS Data

We present a catalog of 799 clusters of galaxies in the redshift range z_est = 0.05 - 0.3 selected from ~400 deg^2 of early SDSS commissioning data along the celestial equator. The catalog is based on merging two independent selection methods -- a color-magnitude red-sequence maxBCG technique (B), and a Hybrid Matched-Filter method (H). The BH catalog includes clusters with richness \Lambda >= 40 (Matched-Filter) and N_gal >= 13 (maxBCG), corresponding to typical velocity dispersion of \sigma_v >~ 400 km s^{-1} and mass (within 0.6 h^{-1) Mpc radius) >~ 5*10^{13} h^{-1} M_sun. This threshold is below Abell richness class 0 clusters. The average space density of these clusters is 2*10^{-5} h^3 Mpc^{-3}. All NORAS X-ray clusters and 53 of the 58 Abell clusters in the survey region are detected in the catalog; the 5 additional Abell clusters are detected below the BH catalog cuts. The cluster richness function is determined and found to exhibit a steeply decreasing cluster abundance with increasing richness. We derive observational scaling relations between cluster richness and observed cluster luminosity and cluster velocity dispersion; these scaling relations provide important physical calibrations for the clusters. The catalog can be used for studies of individual clusters, for comparisons with other sources such as X-ray clusters and AGNs, and, with proper correction for the relevant selection functions, also for statistical analyses of clusters.Comment: AASTeX, 62 pages, including 14 figures and 4 tables, submitted to ApJS. Paper with full-resolution figures at http://astro.princeton.edu/~feng/sdss_cluster.p

The Surface Array planned for IceCube-Gen2

IceCube-Gen2, the extension of the IceCube Neutrino Observatory, will feature three main components: an optical array in the deep ice, a large-scale radio array in the shallow ice and firn, and a surface detector above the optical array. Thus, IceCube-Gen2 will not only be an excellent detector for PeV neutrinos, but also constitutes a unique setup for the measurement of cosmic-ray air showers, where the electromagnetic component and low-energy muons are measured at the surface and high-energy muons are measured in the ice. As for ongoing enhancement of IceCube’s current surface array, IceTop, we foresee a combination of elevated scintillation and radio detectors for the Gen2 surface array, aiming at high measurement accuracy for air showers. The science goals are manifold: The in-situ measurement of the cosmic-ray flux and mass composition, as well as more thorough tests of hadronic interaction models, will improve the understanding of muons and atmospheric neutrinos detected in the ice, in particular, regarding prompt muons. Moreover, the surface array provides a cosmic-ray veto for the in-ice detector and contributes to the calibration of the optical and radio arrays. Last but not least, the surface array will make major contributions to cosmic-ray science in the energy range of the transition from Galactic to extragalactic sources. The increased sensitivities for photons and for cosmic-ray anisotropies at multi-PeV energies provide a chance to solve the puzzle of the origin of the most energetic Galactic cosmic rays and will serve IceCube’s multimessenger mission

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts. June 4-7, 2019, Szczyrk, Polan