Threadable Curves

We define a plane curve to be threadable if it can rigidly pass through a point-hole in a line L without otherwise touching L. Threadable curves are in a sense generalizations of monotone curves. We have two main results. The first is a linear-time algorithm for deciding whether a polygonal curve is threadable---O(n) for a curve of n vertices---and if threadable, finding a sequence of rigid motions to thread it through a hole. We also sketch an argument that shows that the threadability of algebraic curves can be decided in time polynomial in the degree of the curve. The second main result is an O(n polylog n)-time algorithm for deciding whether a 3D polygonal curve can thread through hole in a plane in R^3, and if so, providing a description of the rigid motions that achieve the threading.Comment: 16 pages, 12 figures, 12 references. v2: Revised with brief addendum after Mikkel Abrahamsen pointed us to a relevant reference on "sweepable polygons." v3: Major revisio

Alien Registration- Rogers, Joseph (Rumford, Oxford County)

https://digitalmaine.com/alien_docs/12311/thumbnail.jp

Development of a minimally invasive molecular biomarker for early detection of lung cancer

The diagnostic evaluation of ever smokers with pulmonary nodules represents a growing clinical challenge due to the implementation of lung cancer screening. The high false-positive rate of screening frequently results in the use of unnecessary invasive procedures in patients who are ultimately diagnosed as benign, clearly highlighting the need for additional diagnostic approaches. We previously derived and validated a bronchial epithelial gene-expression biomarker to detect lung cancer in ever smokers. However, bronchoscopy is not always chosen as a diagnostic modality. Given that bronchial and nasal epithelial gene-expression are similarly altered by cigarette smoke exposure, we sought to determine if cancer-associated gene-expression might also be detectable in the more readily accessible nasal epithelium. Nasal epithelial brushings were prospectively collected from ever smokers undergoing diagnostic evaluation for lung cancer in the AEGIS-1 (n=375) and AEGIS-2 (n=130) clinical trials and gene-expression profiled using microarrays. The computational framework used to discover biomarkers in these data was formalized and implemented in an open-source R-package. We identified 535 genes in the nasal epithelium of AEGIS-1 patients whose expression was associated with lung cancer status. Using matched bronchial gene-expression data from a subset of these patients, we found significantly concordant cancer-associated gene-expression alterations between the two airway sites. A nasal lung cancer classifier derived in the AEGIS-1 cohort that combined clinical factors and nasal gene-expression had significantly higher AUC (0.81) and sensitivity (0.91) than the clinical-factor model alone in independent samples from the AEGIS-2 cohort. These results support that the airway epithelial field of lung cancer-associated injury extends to the nose and demonstrates the potential of using nasal gene-expression as a non-invasive biomarker for lung cancer detection. The framework for deriving this biomarker was generalized and implemented in an open-source R-package. The package provides a computational pipeline to compare biomarker development strategies using microarray data. The results from this pipeline can be used to highlight the optimal model development parameters for a given dataset leading to more robust and accurate models. This package provides the community with a novel and powerful tool to facilitate biomarker discovery in microarray data

Poor Relief in the Metropolis.

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Barriers to recovery and recommendations for change: the Pennsylvania Consensus Conference on psychiatry\u27s role.

OBJECTIVE: Recovery has emerged over the past decade as a dominant theme in public mental health care. METHODS: The 2006 Pennsylvania Consensus Conference brought together 24 community psychiatrists to explore the barriers they experienced in promoting recovery and their recommendations for change. RESULTS: Twelve barriers were identified and classified into one of three categories: psychiatry knowledge, roles, and training; the need to transform public mental health systems and services; and environmental barriers to opportunity. Participants made 22 recommendations to address these barriers through changes in policies, programs, and psychiatric knowledge and practice. CONCLUSIONS: The recommendations identify areas for change that can be accomplished through individual psychiatrist action and organized group efforts

How would you react? : exploring heterosexual women's reactions to confrontations of their own homonegative behaviour

To date, little research has explored the utility of inter-personal confrontation as a strategy for the reduction of homonegative attitudes and/or behaviours among heterosexual women. Consequently, the purpose of the current study was to explore three unique aspects of such confrontations among a sample of heterosexual women from the University of Saskatchewan. These three aspects were: 1) to what extent do high- and low-prejudiced women’s reactions to confrontations of subtle homonegative behaviour differ; 2) what differences exist in the way that heterosexual women respond to bias directed towards gay men than to bias directed towards lesbian women; 3) what effect does the vested interest of a confronter have on heterosexual women’s reaction to confrontations of homonegative behaviour. A 2(target condition) X 2(modern homonegativity endorsement) X 4(confronter type) between-subjects design was used wherein 286 female volunteers completed a questionnaire booklet developed for the project. The questionnaire booklet asked participants to first imagine themselves in a scenario where they would be confronted for engaging in subtle homonegative behaviour and to then indicated how they would think, feel, and behave in response to such a confrontation. The results indicated that low-prejudice participants reacted with greater negative-self directed affect (e.g., guilt) and compunction (e.g., apologize for behaviour) than high-prejudice participants when confronted by either a gay man or lesbian woman. Such reactions are important as they mark the initiation of a self-regulatory cycle that allows the individual to avoid such biased behaviour in the future. Limitations of the study and directions for future research concerning inter-personal confrontations of homonegativity are also presented

Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research

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