Simone Weil\u27s Spiritual Critique of Modern Science: An Historical-Critical Assessment

This paper evaluates Simone Weil\u27s philosophy and theology of science from the perspective of an historical phenomenology of science

Cartesian Certainty and the Infinity of the Will

This paper interprets Descartes\u27 conception of certainty as most fundamentally a function of the human will, controlling the cognitive encounter with the world

The American anti-colonial tradition and international accountability for dependent peoples: A study of the American role in the establishment of the League of Nations mandates system and the United Nations trusteeship system.

This thesis examines the American anti-colonial tradition's role in establishing the principle of international accountability for administering dependent peoples in the League of Nations mandates and the United Nations trusteeship systems. Where relevant, British ideas and schemes are compared with American ones in so far as this helps to understand the latter and where the final outcomes were based on Anglo-American compromises. It contributes to the literature on international relations in two main areas. First, it analyses the formulation, development and inter-relation of the American anticolonial tradition and international accountability. Second, it is the first study of the interplay of those two concepts within the context of differing Anglo-American views on creating the mandates and trusteeship systems. There are eight chapters. Chapter 1 introduces the main objectives and themes. Chapters 2 and 3, the conceptual heart of the thesis, examine imperial and colonial relationships, the American anti-colonial tradition, and international accountability for dependent peoples. Chapter 4 focuses on the interplay of those concepts and the American role in establishing the League mandates system. Chapters 5, 6 and 7 do the same regarding the United Nations trusteeship system. Chapter 7 also contains a postscript on trusteeship developments since 1945. Chapter 8 summarises the thesis' conclusions. Throughout, the methodological approach is analytical and historical rather than theoretical. The overall conclusion is that so long as the national interests of the United States were protected, the American anti-colonial tradition did play the major role in establishing the principle of international accountability within both the mandates and the trusteeship systems. The determination and anti-colonial sentiments of Presidents Woodrow Wilson and Franklin Roosevelt were especially important. American policy was usually based on the right of all peoples to freedom; the practical application of this precept hastened the demise of Western European-style colonialism

Adsorption of Carbon Dioxide, Ammonia, Formaldehyde, and Water Vapor on Regenerable Carbon Sorbents

Results are presented on the development of reversible sorbents for the combined carbon dioxide, moisture, and tracecontaminant (TC) removal for use in Extravehicular Activities (EVAs), and more specifically in the Primary Life Support System (PLSS). The currently available life support systems use separate units for carbon dioxide, trace contaminants, and moisture control, and the longterm objective is to replace the above three modules with a single one. Furthermore, the current TCcontrol technology involves the use of a packed bed of acidimpregnated granular charcoal, which is nonregenerable, and the carbonbased sorbent under development in this project can be regenerated by exposure to vacuum at room temperature. In this study, several carbon sorbents were fabricated and tested for simultaneous carbon dioxide, ammonia, formaldehyde, and water sorption. Multiple adsorption/vacuumregeneration cycles were demonstrated at room temperature, and also the enhancement of formaldehyde sorption by the presence of ammonia in the gas mixture

An incomplete correlation between pre-salt topography, top reservoir erosion, and salt deformation in deep-water Santos Basin (SE Brazil)

In deep-water Santos Basin, SE Brazil, hypersaline conditions during the Aptian resulted in the accumulation of halite and carnallite over which stratified evaporites, carbonates and shales were folded, translated downslope and thrusted above syn-rift structures. As a result, high-quality 3D seismic data reveal an incomplete relationship between pre-salt topography and the development of folds and thrusts in Aptian salt and younger units. In the study area, three characteristics contrast with known postulates on passive margins’ fold-and-thrust belts: a) the largest thrusts do not necessarily occur where the salt is thicker, b) synthetic-to-antithetic fault ratios are atypically high on the distal margin, and c) regions of intense folding do not necessarily coincide with the position of the larger syn-rift horsts and ramps below the salt. Regions marked by important erosion and truncation of pre-salt strata, uplifted and exposed sub-aerially before the deposition of Aptian salt, can form structural lows at present or be part of horsts uplifted after the Aptian. This is an observation that suggests significant intra-salt shear drag above pre-salt structural highs during Aptian-Late Cretaceous gravitational gliding, but not on younger horsts and ramps reactivated after the main phase of salt movement. Either formed by drag or sub-aerial erosion, strata truncation below the Aptian salt does not correlate with the present-day pre-salt structure in terms of its magnitude and distribution. In addition, there is a marked increase in deformation towards the distal margin, where low-angle thrusts are ubiquitous on seismic data. The geometry and large synthetic-to-antithetic fault ratios of post-salt strata on the distal margin lead us to consider a combination of gravitational gliding of salt from the northwest and ridge push from the east as responsible for the observed styles of salt deformation

The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA

BACKGROUND: Upon exposure to agents that damage DNA, Saccharomyces cerevisiae undergo widespread reprogramming of gene expression. Such a vast response may be due not only to damage to DNA but also damage to proteins, RNA, and lipids. Here the transcriptional response of S. cerevisiae specifically induced by DNA damage was discerned by exposing S. cerevisiae to a panel of three "radiomimetic" enediyne antibiotics (calicheamicin γ(1)(I), esperamicin A1 and neocarzinostatin) that bind specifically to DNA and generate varying proportions of single- and double-strand DNA breaks. The genome-wide responses were compared to those induced by the non-selective oxidant γ-radiation. RESULTS: Given well-controlled exposures that resulted in similar and minimal cell death (~20–25%) across all conditions, the extent of gene expression modulation was markedly different depending on treatment with the enediynes or γ-radiation. Exposure to γ-radiation resulted in more extensive transcriptional changes classified both by the number of genes modulated and the magnitude of change. Common biological responses were identified between the enediynes and γ-radiation, with the induction of DNA repair and stress response genes, and the repression of ribosomal biogenesis genes. Despite these common responses, a fraction of the response induced by gamma radiation was repressed by the enediynes and vise versa, suggesting that the enediyne response is not entirely "radiomimetic." Regression analysis identified 55 transcripts with gene expression induction associated both with double- or single-strand break formation. The S. cerevisiae "DNA damage signature" genes as defined by Gasch et al. [1] were enriched among regulated transcripts associated with single-strand breaks, while genes involved in cell cycle regulation were associated with double-strand breaks. CONCLUSION: Dissection of the transcriptional response in yeast that is specifically signaled by DNA strand breaks has identified that single-strand breaks provide the signal for activation of transcripts encoding proteins involved in the DNA damage signature in S. cerevisiae, and double-strand breaks signal changes in cell cycle regulation genes

Torrefaction Processing for Human Solid Waste Management

This study involved a torrefaction (mild pyrolysis) processing approach that could be used to sterilize feces and produce a stable, odor-free solid product that can be stored or recycled, and also to simultaneously recover moisture. It was demonstrated that mild heating (200-250 C) in nitrogen or air was adequate for torrefaction of a fecal simulant and an analog of human solid waste (canine feces). The net result was a nearly undetectable odor (for the canine feces), complete recovery of moisture, some additional water production, a modest reduction of the dry solid mass, and the production of small amounts of gas and liquid. The liquid product is mainly water, with a small Total Organic Carbon content. The amount of solid vs gas plus liquid products can be controlled by adjusting the torrefaction conditions (final temperature, holding time), and the current work has shown that the benefits of torrefaction could be achieved in a low temperature range (< 250 C). These temperatures are compatible with the PTFE bag materials historically used by NASA for fecal waste containment and will reduce the energy consumption of the process. The solid product was a dry material that did not support bacterial growth and was hydrophobic relative to the starting material. In the case of canine feces, the solid product was a mechanically friable material that could be easily compacted to a significantly smaller volume (approx. 50%). The proposed Torrefaction Processing Unit (TPU) would be designed to be compatible with the Universal Waste Management System (UWMS), now under development by NASA. A stand-alone TPU could be used to treat the canister from the UWMS, along with other types of wet solid wastes, with either conventional or microwave heating. Over time, a more complete integration of the TPU and the UWMS could be achieved, but will require design changes in both units

Differential expression analysis with global network adjustment

&lt;p&gt;Background: Large-scale chromosomal deletions or other non-specific perturbations of the transcriptome can alter the expression of hundreds or thousands of genes, and it is of biological interest to understand which genes are most profoundly affected. We present a method for predicting a gene’s expression as a function of other genes thereby accounting for the effect of transcriptional regulation that confounds the identification of genes differentially expressed relative to a regulatory network. The challenge in constructing such models is that the number of possible regulator transcripts within a global network is on the order of thousands, and the number of biological samples is typically on the order of 10. Nevertheless, there are large gene expression databases that can be used to construct networks that could be helpful in modeling transcriptional regulation in smaller experiments.&lt;/p&gt; &lt;p&gt;Results: We demonstrate a type of penalized regression model that can be estimated from large gene expression databases, and then applied to smaller experiments. The ridge parameter is selected by minimizing the cross-validation error of the predictions in the independent out-sample. This tends to increase the model stability and leads to a much greater degree of parameter shrinkage, but the resulting biased estimation is mitigated by a second round of regression. Nevertheless, the proposed computationally efficient “over-shrinkage” method outperforms previously used LASSO-based techniques. In two independent datasets, we find that the median proportion of explained variability in expression is approximately 25%, and this results in a substantial increase in the signal-to-noise ratio allowing more powerful inferences on differential gene expression leading to biologically intuitive findings. We also show that a large proportion of gene dependencies are conditional on the biological state, which would be impossible with standard differential expression methods.&lt;/p&gt; &lt;p&gt;Conclusions: By adjusting for the effects of the global network on individual genes, both the sensitivity and reliability of differential expression measures are greatly improved.&lt;/p&gt

Multidisciplinary Care of Patients with Intrahepatic Cholangiocarcinoma: Updates in Management

Cholangiocarcinoma is a highly fatal primary cancer of the bile ducts which arises from malignant transformation of bile duct epithelium. While being an uncommon malignancy with an annual incidence in the United States of 5000 new cases, the incidence has been increasing over the past 30 years and comprises 3% of all gastrointestinal cancers. Cholangiocarcinoma can be classified into intrahepatic (ICC) and extrahepatic (including hilar and distal bile duct) according to its anatomic location within the biliary tree with respect to the liver. This paper reviews the management of ICC, focusing on the epidemiology, risk factors, diagnosis, and surgical and nonsurgical management