SNP-SNP interaction with Parkinson's disease risk according to the models from the Lesnick <i>et al.</i> publication.

<p>SNP-SNP interaction with Parkinson's disease risk according to the models from the Lesnick <i>et al.</i> publication.</p

Association results for the putative axon guidance pathway model with Parkinson's risk.

<p>note: A score for each subject was calculated based on the coefficients given in the Lesnick paper.</p><p>Odds ratio represents the increase for each one unit change in the score.</p

Dot plot showing regression scores of individual cases and controls in the Celera and Thessaly sample sets.

<p>A score was calculated for each individual as the sum of the specified main and interaction effects shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002707#pone-0002707-t002" target="_blank">Table 2</a>.</p

Simulation analysis.

<p>(A) Histogram of randomly-selected SNPs and highly-selected SNPs, both generated under a null model and uncorrected for multiple testing. The selected SNPs were obtained by taking the most significant SNP from a set of 1,400 null SNPs. The random SNPs were obtained by randomly-selecting a marker from the 198k SNPs. The 200 presented data points were generated from 200 iterations of the simulation. (B) Distribution of −log(<i>P</i>-value) for global likelihood ratio test from the observed method and the permuted method that mimic Lesnick's model selection scheme (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002707#s4" target="_blank">Materials and Methods</a>). <i>P</i>-values were tallied from 500 observed models and 500 permuted models.</p

Odds ratio analysis for the groups defined by predicted PD probability in the Thessaly sample set.

*<p>Because we didn't have data in the nominal groups that Lesnick et al. defined (our predicted probabilities ranged from 0.328 to 0.634), we did not use the Lesnick et al. groupings. To be able to calculate odds ratios we broke the predicted probabilities into quartiles and calculated the odds ratios for each of the groups.</p>**<p>Wald test with 3 degrees of freedom.</p

Single marker association with Parkinson's disease risk according to the models from the Lesnick <i>et al.</i> publication.

*<p>ADD: log additive; DOM: Mendelian dominant; REC, Mendelian recessive.</p>**<p>Lesnick et al. PLoS Genet 3(6): e98. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002707#pone-0002707-t001" target="_blank">Table 1</a>.</p

Perancangan Interior Cafe Salon Di Malang

Malang City has good prospect in the culinary fields such as cafes and salon, because the consumptive lifestyle as become a trend in Malang City. Cafe is often used as a place to gather and meet the culinary needs, while salon is often used as a place to let saturation off and body pampering. These perspectives brings Malang into a need of a space to fulfill consumer consumptive pattern and to release saturation in Malang City. This design uses the concept of "Care and Relax". The aim of this concept is to create a space needed by the people which is a place that provides comfortable, serene and relax interior for the people inside. This concept also functions to give warm athmosphere. The application of care in the design is by proximity, protection, openess, and attention while the application of relax in the design is by calmness, roomy and light

Ideogram for chromosome 22 from a patient with a fetal microdeletion in the DiGeorge region.

<p>Ideogram for chromosome 22 from a patient with a fetal microdeletion in the DiGeorge region.</p

Microarray data for maternal DNA for the patient in Fig 6.

<p>Microarray data for maternal DNA for the patient in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0167130#pone.0167130.g006" target="_blank">Fig 6</a>.</p

Follow-up of Clinical Samples Positive for Fetal Aneuploidies on Non-invasive Prenatal Screening

<p>Follow-up of Clinical Samples Positive for Fetal Aneuploidies on Non-invasive Prenatal Screening</p