Physical Properties of Pit and Fissure Sealants

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67086/2/10.1177_00220345790580042701.pd

Parameters that Affect the Color of Direct Restorative Resins

The effects of thickness, background color, specular reflection, and surface roughness on the color of five commercial restorative resins were studied by reflection spectrophotometry. As thickness increased, values of luminous reflectance and excitation purity increased for a black background but decreased for a white background. Opacity increased dramatically as thickness increased from 1.3 to 3.9 mm.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67249/2/10.1177_00220345780570090701.pd

Effect of a Light-Emitting Diode on Composite Polymerization Shrinkage and Hardness

Purpose: : This study evaluated the effect of light-emitting diodes (LEDs) on polymerization shrinkage and bottom-to-top hardness ratios of composites. Materials and Methods : Six LEDs (Elipar FreeLight, 3M ESPE, St. Paul, MN, USA; Versalux, Centrix, Shelton, CT, USA; Ultra-Lume LED2, Ultradent, South Jordan, UT, USA; Zap LED only, CMS-Dental/Soft-Core Texas, North Richland Hills, TX, USA; Zap dual light; and L.E.Demetron I, Kerr Manufacturing Inc., Orange, CA, USA) and a quartz-tungsten-halogen (QTH) light (Optilux 501, Kerr Manufacturing Inc.) were tested. Ten specimens each of a microhybrid (Point 4, Kerr Manufacturing, Inc.) and a hybrid (Filtek Z250, 3M ESPE, St. Paul, MN, USA) composite, measuring 2 mm thick by 5 mm in diameter, were polymerized using each of the lights. Linear shrinkage was recorded using a contactless displacement instrument. Ten specimens were also polymerized with each light to determine the Knoop hardness number (KHN) at the top and bottom surfaces. Results : For the microhybrid, Zap dual light had the least volumetric shrinkage 2.08% (± 0.33) and Elipar FreeLight had the highest 3.02% (± 0.73). There was no significant difference ( p < .05) in shrinkage for the LEDs when compared with the Optilux 501. The hybrid showed the least amount of shrinkage with the L.E.Demetron I, 1.42% (± 0.12), and the greatest with the Zap dual light, 2.47% (± 0.31). The Ultra-Lume LED2 ( p < .05) and Zap LED and dual light ( p < .001) had significantly greater shrinkage than did the Optilux 501. Zap LED had the lowest depth of cure with a bottom KHN of 11.46 (± 2.71) and 33.62 (± 3.57) for the microhybrid and hybrid, respectively. The L.E.Demetron I had the highest bottom hardness value for the microhybrid, with a value of 40.65 (± 1.50). The Optilux 501 had the highest bottom hardness value for the hybrid, with a value of 62.03 (± 0.82). The Zap LED and dual light and Versalux lights had significantly lower bottom-to-top hardness ratios than did the QTH ( p < .001) with the microhybrid. Conclusions : There was no statistically significant difference in shrinkage for the microhybrid with any of the lights tested. The hybrid, however, showed significantly less shrinkage with the halogen compared with the Ultra-Lume LED2 and Zap LED and dual light. All LEDs had equal or lower bottom hardness values than did the QTH, except for L.E.Demetron I with the microhybrid.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74916/1/j.1708-8240.2005.tb00096.x.pd

Effects of Cement Bases on the Stresses and Deflections in Composite Restorations

A model was used to show that tensile and shear stresses can occur in sufficient magnitude to cause failure in a cement base supporting a composite material in a posterior Class I restoration. Highest values of stress were observed when lining materials with a low modulus were used.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68080/2/10.1177_00220345760550010301.pd

The Radial Extent and Warp of the Ionized Galactic Disk. I. A VLBA Survey of Extragalactic Sources Toward the Anticenter

We report multifrequency Very Long Baseline Array observations of twelve active galactic nuclei seen toward the Galactic anticenter. All of the sources are at |b| < 10 degrees and seven have |b| < 0.5 degrees. Our VLBA observations can detect an enhancement in the angular broadening of these sources due to an extended H II disk, if the orientation of the H II disk in the outer Galaxy is similar to that of the H I disk. Such an extended H II disk is suggested by the C IV absorption in a quasar's spectrum, the appearance of H I disks of nearby spiral galaxies, and models of Ly-alpha cloud absorbers and the Galactic fountain. We detect eleven of the twelve sources at one or more frequencies; nine of the sources are compact and suitable for an angular broadening analysis. A preliminary analysis of the observed angular diameters suggests that the H II disk does not display considerable warping or flaring and does not extend to large Galactocentric distances (R >~ 100 kpc). A companion paper (Lazio & Cordes 1997) combines these observations with those in the literature and presents a more comprehensive analysis.Comment: 19 pages, LaTeX2e with AASTeX macro aaspp4, accepted for publication in ApJS, Vol. 115, 1998 April; Figures 1, 3, and 4 included, for figures of individual sources see http://astrosun.tn.cornell.edu/students/lazio/Anticenter/anticenterI.htm

On the Enhanced Interstellar Scattering Toward B1849+005

(Abridged) This paper reports new Very Large Array (VLA) and Very Long Baseline Array (VLBA) observations of the extragalactic source B1849+005 at frequencies between 0.33 and 15 GHz and the re-analysis of archival VLA observations at 0.33, 1.5, and 4.9 GHz. The structure of this source is complex but interstellar scattering dominates the structure of the central component at least to 15 GHz. An analysis of the phase structure functions of the interferometric visibilities shows the density fluctuations along this line of sight to be anisotropic (axial ratio = 1.3) with a frequency-independent position angle, and having an inner scale of roughly a few hundred kilometers. The anisotropies occur on length scales of order 10^{15} cm (D/5 kpc), which within the context of certain magnetohydrodynamic turbulence theories indicates the length scale on which the kinetic and magnetic energy densities are comparable. A conservative upper limit on the velocity of the scattering material is 1800 km/s. In the 0.33 GHz field of view, there are a number of other sources that might also be heavily scattered. Both B1849+005 and PSR B1849+00 are highly scattered, and they are separated by only 13'. If the lines of sight are affected by the same ``clump'' of scattering material, it must be at least 2.3 kpc distant. However, a detailed attempt to account for the scattering observables toward these sources does not produce a self-consistent set of parameters for such a clump. A clump of H\alpha emission, possibly associated with the H II region G33.418-0.004, lies between these two lines of sight, but it seems unable to account for all of the required excess scattering.Comment: 23 pages, LaTeX2e AASTeX, 13 figures in 14 PostScript files, accepted for publication in Ap

Color Stability of Restorative Resins Under Accelerated Aging

The color stability of seven commercial composite resins, an unfilled resin, and three glazes was studied under conditions of accelerated aging by reflection spectrophotometry and visually with Munsell color tabs. After aging for 900 hours, most of the resins had lower values of luminous reflectance and excitation purity and higher values of dominant wavelength and contrast ratio compared to values at baseline.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66937/2/10.1177_00220345780570111101.pd

The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men

&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Genome-wide association studies (GWAS) have identified 6q25, which incorporates the oestrogen receptor alpha gene (ESR1), as a quantitative trait locus for areal bone mineral density (BMD(a)) of the hip and lumbar spine. The aim of this study was to determine the influence of this locus on other bone health outcomes; calcaneal ultrasound (QUS) parameters, radial peripheral quantitative computed tomography (pQCT) parameters and markers of bone turnover in a population sample of European men.&lt;/p&gt; &lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; Eight single nucleotide polymorphisms (SNP) in the 6q25 locus were genotyped in men aged 40-79 years from 7 European countries, participating in the European Male Ageing Study (EMAS). The associations between SNPs and measured bone parameters were tested under an additive genetic model adjusting for centre using linear regression.&lt;/p&gt; &lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; 2468 men, mean (SD) aged 59.9 (11.1) years had QUS measurements performed and bone turnover marker levels measured. A subset of 628 men had DXA and pQCT measurements. Multiple independent SNPs showed significant associations with BMD using all three measurement techniques. Most notably, rs1999805 was associated with a 0.10 SD (95%CI 0.05, 0.16; p = 0.0001) lower estimated BMD at the calcaneus, a 0.14 SD (95%CI 0.05, 0.24; p = 0.004) lower total hip BMD(a), a 0.12 SD (95%CI 0.02, 0.23; p = 0.026) lower lumbar spine BMD(a) and a 0.18 SD (95%CI 0.06, 0.29; p = 0.003) lower trabecular BMD at the distal radius for each copy of the minor allele. There was no association with serum levels of bone turnover markers and a single SNP which was associated with cortical density was also associated with cortical BMC and thickness.&lt;/p&gt; &lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our data replicate previous associations found between SNPs in the 6q25 locus and BMD(a) at the hip and extend these data to include associations with calcaneal ultrasound parameters and radial volumetric BMD.&lt;/p&gt

Prevalence and severity of antipsychotic related constipation in patients with schizophrenia: a retrospective descriptive study

<p>Abstract</p> <p>Background</p> <p>Antipsychotic are the cornerstone in the treatment of schizophrenia. They also have a number of side-effects. Constipation is thought to be common, and a potential serious side-effect, which has received little attention in recent literature.</p> <p>Method</p> <p>We performed a retrospective study in consecutively admitted patients, between 2007 and 2009 and treated with antipsychotic medication, linking different electronic patient data to evaluate the prevalence and severity of constipation in patients with schizophrenia under routine treatment conditions.</p> <p>Results</p> <p>Over a period of 22 months 36.3% of patients (99) received at least once a pharmacological treatment for constipation. On average medication for constipation was prescribed for 273 days. Severe cases (N = 50), non-responsive to initial treatment, got a plain x-ray of the abdomen. In 68.4% fecal impaction was found.</p> <p>Conclusion</p> <p>A high prevalence of constipation, often severe and needing medical interventions, was confirmed during the study period. Early detection, monitoring over treatment and early intervention of constipation could prevent serious consequences such as ileus.</p

Association between depressive symptoms and incident cardiovascular diseases

Importance: It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVD). Objective: To characterize the association between depressive symptoms and CVD incidence across the spectrum of lower mood. Design, setting and participants: A pooled analysis of individual-participant-data from the Emerging Risk Factors Collaboration (ERFC; 162,036 participants; 21 cohorts; baseline surveys, 1960-2008; latest follow-up, March 2020) and UK Biobank (UKB; 401,219 participants; baseline surveys, 2006-2010; latest follow-up, March 2020). Eligible participants had information about self-reported depressive symptoms and no CVD history at baseline. Exposure: Depressive symptoms were recorded using validated instruments. ERFC scores were harmonized across studies to a scale representative of the Centre for Epidemiological Studies Depression scale (CES-D; range 0-60; ≥16 indicates possible depressive disorder). UKB recorded the Patient Health Questionnaire-2 (PHQ-2; range 0-6; ≥3 indicates possible depressive disorder). Main Outcomes and Measures: Primary outcomes were incident fatal/nonfatal coronary heart disease (CHD), stroke and CVD (composite of CHD and stroke). Hazard ratios (HRs) per 1-SD higher log-CES-D or PHQ-2 adjusted for age, sex, smoking and diabetes were reported. Results: Among 162,036 participants from the ERFC, 73% were female, mean (SD) age at baseline was 63 (9) years, and 5,078 CHD and 3,932 stroke events were recorded (median follow-up, 9.5-years). Associations with CHD, stroke and CVD were log-linear. HRs (95%CI) per 1SD higher depression score for CHD, stroke and CVD respectively were 1.07 (1.03-1.11), 1.05 (1.01-1.10), and 1.06 (1.04-1.08). This reflects, 36 versus 29 CHD events, 28 versus 25 stroke events, and 63 versus 54 CVD events per 1000 individuals over 10 years in the highest versus lowest quintile of CES-D (geometric mean CES-D score, 19 versus 1). Among 401,219 participants from the UKB, 55% were female, mean baseline age was 56 (8) years, and 4607 CHD and 3253 stroke events were recorded (median follow-up, 8.1-years). HRs per 1SD higher depression score for CHD, stroke and CVD respectively were 1.11 (1.08-1.14), 1.10 (1.06-1.14) and 1.10 (1.08-1.13). This reflects, 21 versus 14 CHD events, 15 versus 10 stroke events, and 36 versus 25 CVD events per 1000 individuals over 10 years in those with PHQ2 ≥4 versus 0. The magnitude and statistical significance of the HRs were not materially changed after adjustment for additional risk factors. Conclusions and Relevance: In a pooled analysis of 563,255 participants in 22 cohorts, baseline depressive symptoms were associated with CVD incidence, including at symptom levels below the threshold indicative of a depressive disorder. However, the magnitude of associations was modest.Lisa Pennells, Stephen Kaptoge and Sarah Spackman are funded by a British Heart Foundation Programme Grant (RG/18/13/33946). Steven Bell was funded by the National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). Tom Bolton is funded by the National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). Angela Wood is supported by a BHF-Turing Cardiovascular Data Science Award and by the EC-Innovative Medicines Initiative (BigData@Heart). John Danesh holds a British Heart Foundation Professorship and a National Institute for Health Research Senior Investigator Award.* *The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care