Are Textual Recommendations Enough? Guiding Physicians Toward the Design of Machine Learning Pipelines Through a Visual Platform

The prevalence of artificial intelligence (AI) in our daily lives is often exaggerated by the media, leading to a positive public perception while overlooking potential problems. In the field of medicine, it is crucial to educate future healthcare professionals on the advantages and disadvantages of AI and to emphasize the importance of creating fair, ethical, and reproducible models. The KoopaML platform was developed to provide an educational and user-friendly interface for inexperienced users to create AI pipelines. This study analyzes the quantitative and interaction data gathered from a usability test involving physicians from the University Hospital of Salamanca, with the aim of identifying new interaction paradigms to improve the platform’s usability. The results shown that the platform is difficult to learn for inexperienced users due to its contents related to AI. Following these results, a set of improvements are proposed for the next version of KoopaML, focusing on reducing the interactions needed to create the pipelines

Flexible Heuristics for Supporting Recommendations Within an AI Platform Aimed at Non-expert Users

The use of Machine Learning (ML) to resolve complex tasks has become popular in several contexts. While these approaches are very effective and have many related benefits, they are still very tricky for the general audience. In this sense, expert knowledge is crucial to apply ML algorithms properly and to avoid potential issues. However, in some situations, it is not possible to rely on experts to guide the development of ML pipelines. To tackle this issue, we present an approach to provide customized heuristics and recommendations through a graphical platform to build ML pipelines, namely KoopaML, focused on the medical domain.With this approach, we aim not only at providing an easy way to apply ML for non-expert users, but also at providing a learning experience for them to understand how these methods work

Las matemáticas en la educación secundaria obligatoria

Se trata de dos unidades didácticas relativas al área de las matemáticas, ante la necesidad de utilizar conceptos básicos trabajados en otras áreas curriculares, y así desvincular la idea de dicha materia como compartimento estanco, y desarrollar ejercicios prácticos y funcionales, adaptados a los alumnos de segundo ciclo de la E.S.O. La primera unidad didáctica titulada 'El plano del Tesoro' y cuyos autores son Luis V. Fernández Muiños y María Fe Conde Alonso, desarrolla los objetivos antes mencionados centrándose en el estudio de los sistemas de medidas, los sistemas de referencia en el plano y el concepto de escala. La segunda unidad didáctica títulada 'Estadística descriptiva' y elaborada por Ana María Mendoza Ocharán y otros, va dedicada a abarcar contenidos estadísticos para ser desarrollados en tercer curso de E.S.O..MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5; 28014 Madrid; Tel. +34917748000; [email protected]

An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration

Abstract During bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth factors to the injured bone. We developed a biocompatible, 3D polycaprolactone (PCL) melt electro-written membrane to act as a mimetic periosteum. Poly (ethyl acrylate) coating of the PCL membrane allowed functionalization, mediated by fibronectin and low dose recombinant human BMP-2 (rhBMP-2) (10-25 μg/ml), resulting in efficient, sustained osteoinduction in vitro. In vivo, rhBMP-2 functionalized mimetic periosteum demonstrated regenerative potential in the treatment of rat critical-size femoral defects with highly efficient healing and functional recovery (80%-93%). Mimetic periosteum has also proven to be efficient for cell delivery, as observed through the migration of transplanted periosteum-derived mesenchymal cells to the bone defect and their survival. Ultimately, mimetic periosteum demonstrated its ability to deliver key stem cells and morphogens to an injured site, exposing a therapeutic and translational potential in vivo when combined with unprecedentedly low rhBMP-2 doses

An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration

During bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth factors to the injured bone. We developed a biocompatible, 3D polycaprolactone (PCL) melt electro-written membrane to act as a mimetic periosteum. Poly (ethyl acrylate) coating of the PCL membrane allowed functionalization, mediated by fibronectin and low dose recombinant human BMP-2 (rhBMP-2) (10-25 mu g/ml), resulting in efficient, sustained osteoinduction in vitro. In vivo, rhBMP-2 functionalized mimetic periosteum demonstrated regenerative potential in the treatment of rat critical-size femoral defects with highly efficient healing and functional recovery (80%-93%). Mimetic periosteum has also proven to be efficient for cell delivery, as observed through the migration of transplanted periosteum-derived mesenchymal cells to the bone defect and their survival. Ultimately, mimetic periosteum demonstrated its ability to deliver key stem cells and morphogens to an injured site, exposing a therapeutic and translational potential in vivo when combined with unprecedentedly low rhBMP-2 doses

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present