Expert consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the determination of biomarkers in pancreatic and biliary tract cancer

Biliary tract cancer; Predictive value; Targeted therapiesCáncer de vías biliares; Valor predictivo; Terapias dirigidasCàncer de vies biliars; Valor predictiu; Teràpies dirigidesPancreatic cancer and biliary tract cancer have a poor prognosis. In recent years, the development of new diagnostic techniques has enabled the identification of the main genetic alterations involved in the development of these tumours. Multiple studies have assessed the ability of certain biomarkers, such as BRCA in pancreatic cancer, IDH1 or FGFR2 in biliary tract cancer and microsatellite instability or NTRK fusions in an agnostic tumour fashion, to predict response to treatment. In this consensus, a group of experts selected by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviewed the role played by these mutations in the process of carcinogenesis and their clinical implications. As a result, this article proposes a series of recommendations to optimize the determination of these biomarkers to help standardize the diagnosis and treatment of these tumours.SEOM and SEAP acknowledge the financial support for this project in the form of unrestricted collaboration in the logistics from AstraZeneca

Helium identification with LHCb

The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using $pp$ collision data at $\sqrt{s}=13\,{\rm TeV}$ recorded by the LHCb experiment in the years 2016 to 2018, corresponding to an integrated luminosity of $5.5\,{\rm fb}^{-1}$. A total of around $10^5$ helium and antihelium candidates are identified with negligible background contamination. The helium identification efficiency is estimated to be approximately $50\%$ with a corresponding background rejection rate of up to $\mathcal O(10^{12})$. These results demonstrate the feasibility of a rich programme of measurements of QCD and astrophysics interest involving light nuclei

Study of Bc+→χcπ+B_c^+ \rightarrow \chi_c \pi^+ decays

International audienceA study of $B_c^+ \rightarrow \chi_c \pi^+$ decays is reported using proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity of 9fb$^{-1}$. The decay $B_c^+ \rightarrow \chi_{c2} \pi^+$ is observed for the first time, with a significance exceeding seven standard deviations. The relative branching fraction with respect to the $B_c^+ \rightarrow J/\psi \pi^+$ decay is measured to be $$\frac{\mathcal{B}_{B_c^+ \rightarrow \chi_{c2} \pi^+}} {\mathcal{B}_{B_c^+ \rightarrow J/\psi \pi^+}} = 0.37 \pm 0.06 \pm 0.02 \pm 0.01 ,$$ where the first uncertainty is statistical, the second is systematic, and the third is due to the knowledge of the $\chi_c \rightarrow J/\psi \gamma$ branching fraction. No significant $B_c^+ \rightarrow \chi_{c1} \pi^+$ signal is observed and an upper limit for the relative branching fraction for the $B_c^+ \rightarrow \chi_{c1} \pi^+$ and $B_c^+ \rightarrow \chi_{c2} \pi^+$ decays of $$\frac{\mathcal{B}_{B_c^+ \rightarrow \chi_{c1} \pi^+}} {\mathcal{B}_{B_c^+ \rightarrow \chi_{c2} \pi^+}} < 0.49$$ is set at the 90% confidence level

Observation of Λb0→Λc+Dˉ(∗)0K−\Lambda_{b}^{0} \to \Lambda_{c}^{+} \bar{D}^{(*)0} K^{-} and Λb0→Λc+Ds∗−\Lambda_{b}^{0} \to \Lambda_{c}^{+} D_{s}^{*-} decays

International audienceThe decays $\Lambda_b^0 \to \Lambda_c^+\bar{D}^{(*)0}K^-$ and $\Lambda_b^0 \to \Lambda_c^+ D_s^{*-}$ are observed for the first time, in proton-proton collision data at $\sqrt{s}=13$TeV corresponding to an integrated luminosity of 5.4 fb${}^{-1}$ collected with the LHCb detector. Their ratios of branching fractions with respect to the $\Lambda_b^0\!\to\Lambda_c^+\mathrm{D}_s^-$ mode are measured to be \begin{align*} \begin{split} \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+\bar{D}^0 K^-)}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 0.1908 {}_{-0.0034}^{+0.0036} {}_{-0.0018}^{+0.0016} \pm 0.0038 \\ \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+\bar{D}^{*0} K^-)}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 0.589 {}_{-0.017}^{+0.018} {}_{-0.018}^{+0.017} \pm 0.012 \\ \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^{*-})}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 1.668 \pm 0.022 {}_{-0.055}^{+0.061}\ , \end{split} \end{align*} where the first uncertainties are statistical, the second systematic, and the third, for the $\Lambda_b^0 \to \Lambda_c^+ \bar{D}^{(*)0} K^-$ decays, are due to the uncertainties on the branching fractions of the $D_s^- \to K^- K^+ \pi^-$ and $\bar{D}^0 \to K^+\pi^-$ decay modes. The measured branching fractions probe factorization assumptions in effective theories and provide the normalization for future pentaquark searches in $\Lambda_b^0 \to \Lambda_c^+ \bar{D}^{(*)0}K^-$ decay channels

Determination of short- and long-distance contributions in B0→K∗0μ+μ−B^{0}\to K^{*0}\mu^+\mu^- decays

International audienceAn amplitude analysis of the $B^0 \to K^{*0} \mu^+\mu^-$ decay is presented. The analysis is based on data collected by the LHCb experiment from proton-proton collisions at $\sqrt{s} = 7,\,8$ and $13$ TeV, corresponding to an integrated luminosity of $4.7$ fb$^{-1}$. For the first time, Wilson coefficients and non-local hadronic contributions are accessed directly from the unbinned data, where the latter are parameterised as a function of $q^2$ with a polynomial expansion. Wilson coefficients and non-local hadronic parameters are determined under two alternative hypotheses: the first relies on experimental information alone, while the second one includes information from theoretical predictions for the non-local contributions. Both models obtain similar results for the parameters of interest. The overall level of compatibility with the Standard Model is evaluated to be between 1.8 and 1.9 standard deviations when looking at the $\mathcal{C}_9$ Wilson coefficient alone, and between 1.3 and 1.4 standard deviations when considering the full set of $\mathcal{C}_9, \, \mathcal{C}_{10}, \, \mathcal{C}_9^\prime$ and $\mathcal{C}_{10}^\prime$ Wilson coefficients. The ranges reflect the theoretical assumptions made in the analysis

Charge-dependent curvature-bias corrections using a pseudomass method

International audienceMomentum measurements for very high momentum charged particles, such as muons from electroweak vector boson decays, are particularly susceptible to charge-dependent curvature biases that arise from misalignments of tracking detectors. Low momentum charged particles used in alignment procedures have limited sensitivity to coherent displacements of such detectors, and therefore are unable to fully constrain these misalignments to the precision necessary for studies of electroweak physics. Additional approaches are therefore required to understand and correct for these effects. In this paper the curvature biases present at the LHCb detector are studied using the pseudomass method in proton-proton collision data recorded at centre of mass energy $\sqrt{s}=13$ TeV during 2016, 2017 and 2018. The biases are determined using $Z\to\mu^+\mu^-$ decays in intervals defined by the data-taking period, magnet polarity and muon direction. Correcting for these biases, which are typically at the $10^{-4}$ GeV$^{-1}$ level, improves the $Z\to\mu^+\mu^-$ mass resolution by roughly 20% and eliminates several pathological trends in the kinematic-dependence of the mean dimuon invariant mass

A measurement of ΔΓs\Delta \Gamma_{s}

Using a dataset corresponding to 9 fb$^{−1}$ of integrated luminosity collected with the LHCb detector between 2011 and 2018 in proton-proton collisions, the decay-time distributions of the decay modes ${B}_s^0\to J/{\psi \eta}^{\prime }$ and ${B}_s^0\to J/\psi {\pi}^{+}{\pi}^{-}$ are studied. The decay-width difference between the light and heavy mass eigenstates of the ${B}_s^0$ meson is measured to be ∆Γ$_{s}$ = 0.087 ± 0.012 ± 0.009 ps$^{−1}$, where the first uncertainty is statistical and the second systematic.[graphic not available: see fulltext]Using a dataset corresponding to $9~\mathrm{fb}^{-1}$ of integrated luminosity collected with the LHCb detector between 2011 and 2018 in proton-proton collisions, the decay-time distributions of the decay modes $B_s^0 \rightarrow J/\psi \eta'$ and $B_s^0 \rightarrow J/\psi \pi^{+} \pi^{-}$ are studied. The decay-width difference between the light and heavy mass eigenstates of the $B_s^0$ meson is measured to be $\Delta \Gamma_s = 0.087 \pm 0.012 \pm 0.009 \, \mathrm{ps}^{-1}$, where the first uncertainty is statistical and the second systematic