Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers

Neural stem cells within the subventricular zone were identified as cells of origin driving growth of high-grade gliomas, and anatomical involvement of the subventricular zone has been associated with an inferior clinical outcome. Whether the association between poor outcome and subventricular zone involvement also applies to glioma of lower grades is unclear. We therefore analysed a retrospective cohort of 182 patients with glioma grade 2 (according to the WHO 2016 classification) including 78 individuals (43%) with subventricular zone involvement. Patients with and without subventricular zone involvement did not differ in regard to demographics, histopathology, and molecular markers. Notably, subventricular zone involvement was a negative prognostic marker for malignant progression and overall survival on uni- and multivariate analysis. When patients were stratified according to the cIMPACT-NOW update 6, subventricular zone involvement was negatively associated with outcome in IDH-wildtype astrocytomas and 1p19q-codeleted oligodendrogliomas but not in IDH-mutant astrocytomas. Collectively, subventricular zone involvement may represent a risk factor for worse outcome in glioma WHO grade 2 depending on the molecular tumor signature. The present data confirm the relevance of molecular glioma classifications as proposed by the cIMPACT-NOW update 6. These findings warrant evaluation in prospective cohorts

Political trust and historical legacy: the effect of varieties of socialism

This paper, unlike the vast existing literature on political trust, focuses on trust in post-socialist countries, and more specifically on their emerging elites, rather than on their general populations. Studying emerging elites is important in the context of establishing democracy and the survival of democracy. We stipulate that political trust is significantly determined by historical legacy: type of socialist regime, accounting for path dependence and thus, for pre- socialist legacies. Utilizing individual-level data from an institutional survey, we find that distinguishing between different types of socialism is instrumental in explaining trust of emerging elites. Our findings have implications for policies aimed at fostering political trust in post-socialist countries and more importantly for discerning future patterns of political and social developments