105 research outputs found
Tensor network states and geometry
Tensor network states are used to approximate ground states of local
Hamiltonians on a lattice in D spatial dimensions. Different types of tensor
network states can be seen to generate different geometries. Matrix product
states (MPS) in D=1 dimensions, as well as projected entangled pair states
(PEPS) in D>1 dimensions, reproduce the D-dimensional physical geometry of the
lattice model; in contrast, the multi-scale entanglement renormalization ansatz
(MERA) generates a (D+1)-dimensional holographic geometry. Here we focus on
homogeneous tensor networks, where all the tensors in the network are copies of
the same tensor, and argue that certain structural properties of the resulting
many-body states are preconditioned by the geometry of the tensor network and
are therefore largely independent of the choice of variational parameters.
Indeed, the asymptotic decay of correlations in homogeneous MPS and MERA for
D=1 systems is seen to be determined by the structure of geodesics in the
physical and holographic geometries, respectively; whereas the asymptotic
scaling of entanglement entropy is seen to always obey a simple boundary law --
that is, again in the relevant geometry. This geometrical interpretation offers
a simple and unifying framework to understand the structural properties of, and
helps clarify the relation between, different tensor network states. In
addition, it has recently motivated the branching MERA, a generalization of the
MERA capable of reproducing violations of the entropic boundary law in D>1
dimensions.Comment: 18 pages, 18 figure
Many body physics from a quantum information perspective
The quantum information approach to many body physics has been very
successful in giving new insight and novel numerical methods. In these lecture
notes we take a vertical view of the subject, starting from general concepts
and at each step delving into applications or consequences of a particular
topic. We first review some general quantum information concepts like
entanglement and entanglement measures, which leads us to entanglement area
laws. We then continue with one of the most famous examples of area-law abiding
states: matrix product states, and tensor product states in general. Of these,
we choose one example (classical superposition states) to introduce recent
developments on a novel quantum many body approach: quantum kinetic Ising
models. We conclude with a brief outlook of the field.Comment: Lectures from the Les Houches School on "Modern theories of
correlated electron systems". Improved version new references adde
Bioinformatics tools for cancer metabolomics
It is well known that significant metabolic change take place as cells are transformed from normal to malignant. This review focuses on the use of different bioinformatics tools in cancer metabolomics studies. The article begins by describing different metabolomics technologies and data generation techniques. Overview of the data pre-processing techniques is provided and multivariate data analysis techniques are discussed and illustrated with case studies, including principal component analysis, clustering techniques, self-organizing maps, partial least squares, and discriminant function analysis. Also included is a discussion of available software packages
Group B Streptococcus vaccine development: present status and future considerations, with emphasis on perspectives for low and middle income countries.
Globally, group B Streptococcus (GBS) remains the leading cause of sepsis and meningitis in young infants, with its greatest burden in the first 90 days of life. Intrapartum antibiotic prophylaxis (IAP) for women at risk of transmitting GBS to their newborns has been effective in reducing, but not eliminating, the young infant GBS disease burden in many high income countries. However, identification of women at risk and administration of IAP is very difficult in many low and middle income country (LMIC) settings, and is not possible for home deliveries. Immunization of pregnant women with a GBS vaccine represents an alternate pathway to protecting newborns from GBS disease, through the transplacental antibody transfer to the fetus in utero. This approach to prevent GBS disease in young infants is currently under development, and is approaching late stage clinical evaluation. This manuscript includes a review of the natural history of the disease, global disease burden estimates, diagnosis and existing control options in different settings, the biological rationale for a vaccine including previous supportive studies, analysis of current candidates in development, possible correlates of protection and current status of immunogenicity assays. Future potential vaccine development pathways to licensure and use in LMICs, trial design and implementation options are discussed, with the objective to provide a basis for reflection, rather than recommendations
A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism
Genome-scale metabolic models (GEMs) represent extensive knowledgebases that provide a platform for model simulations and integrative analysis of omics data. This study introduces Yeast8 and an associated ecosystem of models that represent a comprehensive computational resource for performing simulations of the metabolism of Saccharomyces cerevisiae––an important model organism and widely used cell-factory. Yeast8 tracks community development with version control, setting a standard for how GEMs can be continuously updated in a simple and reproducible way. We use Yeast8 to develop the derived models panYeast8 and coreYeast8, which in turn enable the reconstruction of GEMs for 1,011 different yeast strains. Through integration with enzyme constraints (ecYeast8) and protein 3D structures (proYeast8DB), Yeast8 further facilitates the exploration of yeast metabolism at a multi-scale level, enabling prediction of how single nucleotide variations translate to phenotypic traits
The Influence of Law and Economics Scholarship on Contract Law: Impressions Twenty-Five Years Later
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