1,864 research outputs found
The effects of degassing on magmatic gas waves and long period eruptive precursors at silicic volcanoes
Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 125 (10), (2020): e2020JB019755, https://doi.org/10.1029/2020JB019755Cyclical ground deformation, associated seismicity, and elevated degassing are important precursors to explosive eruptions at silicic volcanoes. Regular intervals for elevated activity (6–30 hr) have been observed at volcanoes such as Mount Pinatubo in the Philippines and Soufrière Hills in Montserrat. Here, we explore a hypothesis originally proposed by Michaut et al. (2013, https://doi.org/10.1038/ngeo1928) where porosity waves containing magmatic gas are responsible for the observed periodic behavior. We use two‐phase theory to construct a model where volatile‐rich, bubbly, viscous magma rises and decompresses. We conduct numerical experiments where magma gas waves with various frequencies are imposed at the base of the model volcanic conduit. We numerically verify the results of Michaut et al. (2013, https://doi.org/10.1038/ngeo1928) and then expand on the model by allowing magma viscosity to vary as a function of dissolved water and crystal content. Numerical experiments show that gas exsolution tends to damp the growth of porosity waves during decompression. The instability and resultant growth or decay of gas wave amplitude depends strongly on the gas density gradient and the ratio of the characteristic magma extraction rate to the characteristic magma degassing rate (Damköhler number, Da). We find that slow degassing can lead to a previously unrecognized filtering effect, where low‐frequency gas waves may grow in amplitude. These waves may set the periodicity of the eruptive precursors, such as those observed at Soufrière Hills Volcano. We demonstrate that degassed, crystal‐rich magma is susceptible to the growth of gas waves which may result in the periodic behavior.J. S. J. and D. B. were supported by NSF grant EAR‐1645057. C. M. has received financial support of the IDEXLyon Project of the University of Lyon in the frame of the Programme Investissements dAvenir (ANR‐16‐IDEX‐0005)
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Charge Detection Mass Spectrometry Reveals Conformational Heterogeneity in Megadalton-Sized Monoclonal Antibody Aggregates
Aggregation of protein-based therapeutics can occur during development, production, or storage and can lead to loss of efficacy and potential toxicity. Native mass spectrometry of a covalently linked pentameric monoclonal antibody complex with a mass of ∼800 kDa reveals several distinct conformations, smaller complexes, and abundant higher-order aggregates of the pentameric species. Charge detection mass spectrometry (CDMS) reveals individual oligomers up to the pentamer mAb trimer (15 individual mAb molecules; ∼2.4 MDa) whereas intermediate aggregates composed of 6-9 mAb molecules and aggregates larger than the pentameric dimer (1.6 MDa) were not detected/resolved by standard mass spectrometry, size exclusion chromatography (SEC), capillary electrophoresis (CE-SDS), or by mass photometry. Conventional quadrupole time-of-flight mass spectrometry (QTOF MS), mass photometry, SEC, and CE-SDS did not resolve partially or more fully unfolded conformations of each oligomer that were readily identified using CDMS by their significantly higher extents of charging. Trends in the charge-state distributions of individual oligomers provides detailed insight into how the structures of compact and elongated mAb aggregates change as a function of aggregate size. These results demonstrate the advantages of CDMS for obtaining accurate masses and information about the conformations of large antibody aggregates despite extensive overlapping m/z values. These results open up the ability to investigate structural changes that occur in small, soluble oligomers during the earliest stages of aggregation for antibodies or other proteins
Ultrahigh-throughput generation and characterization of cellular aggregates in laser-ablated microwells of poly(dimethylsiloxane)
Aggregates of cells, also known as multicellular aggregates (MCAs), have been used as microscale tissues in the fields of cancer biology, regenerative medicine, and developmental biology for many decades. However, small MCAs (fewer than 100 cells per aggregate) have remained challenging to manufacture in large quantities at high uniformity. Forced aggregation into microwells offers a promising solution for forming consistent aggregates, but commercial sources of microwells are expensive, complicated to manufacture, or lack the surface packing densities that would significantly improve MCA production. To address these concerns, we custom-modified a commercial laser cutter to provide complete control over laser ablation and directly generate microwells in a poly(dimethylsiloxane) (PDMS) substrate. We achieved ultra rapid microwell production speeds (>50000 microwells per h) at high areal packing densities (1800 microwells per cm2) and over large surface areas for cell culture (60 cm2). Variation of the PDMS substrate distance from the laser focal plane during ablation allowed for the generation of microwells with a variety of sizes, contours, and aspect ratios. Casting of high-fidelity microneedle masters in polyurethane allowed for non-ablative microwell reproduction through replica molding. MCAs of human bone marrow derived mesenchymal stem cells (hMSCs), murine 344SQ metastatic adenocarcinoma cells, and human C4-2 prostate cancer cells were generated in our system with high uniformity within 24 hours, and computer vision software aided in the ultra-high-throughput analysis of harvested aggregates. Moreover, MCAs maintained invasive capabilities in 3D migration assays. In particular, 344SQ MCAs demonstrated epithelial lumen formation on Matrigel, and underwent EMT and invasion in the presence of TGF-β. We expect this technique to find broad utility in the generation and cultivation of cancer cell aggregates, primary cell aggregates, and embryoid bodies
Emergent Randomness and Benchmarking from Many-Body Quantum Chaos
Chaotic quantum many-body dynamics typically lead to relaxation of local
observables. In this process, known as quantum thermalization, a subregion
reaches a thermal state due to quantum correlations with the remainder of the
system, which acts as an intrinsic bath. While the bath is generally assumed to
be unobserved, modern quantum science experiments have the ability to track
both subsystem and bath at a microscopic level. Here, by utilizing this
ability, we discover that measurement results associated with small subsystems
exhibit universal random statistics following chaotic quantum many-body
dynamics, a phenomenon beyond the standard paradigm of quantum thermalization.
We explain these observations with an ensemble of pure states, defined via
correlations with the bath, that dynamically acquires a close to random
distribution. Such random ensembles play an important role in quantum
information science, associated with quantum supremacy tests and device
verification, but typically require highly-engineered, time-dependent control
for their preparation. In contrast, our approach uncovers random ensembles
naturally emerging from evolution with a time-independent Hamiltonian. As an
application of this emergent randomness, we develop a benchmarking protocol
which estimates the many-body fidelity during generic chaotic evolution and
demonstrate it using our Rydberg quantum simulator. Our work has wide ranging
implications for the understanding of quantum many-body chaos and
thermalization in terms of emergent randomness and at the same time paves the
way for applications of this concept in a much wider context.Comment: JC and ALS contributed equally to this wor
A new soil-based approach for empirical monitoring of enhanced rock weathering rates
Enhanced Rock Weathering (ERW) is a promising scalable and cost-effective
Carbon Dioxide Removal (CDR) strategy with significant environmental and
agronomic co-benefits. However, a major barrier to the widescale implementation
of ERW is a robust Monitoring, Reporting, and Verification (MRV) framework. To
successfully quantify the amount of carbon dioxide removed by ERW at scale, MRV
must be accurate, precise, and cost-effective. Here, we outline a new method
based on mass balance where metal analysis on soil samples is used to
accurately track the extent of in-situ alkaline mineral weathering. We show
that signal-to-noise issues of in-situ soil analysis can be mitigated by using
isotope-dilution mass spectrometry to reduce analytical error. We implement a
proof of concept experiment demonstrating the method in controlled mesocosms.
In our experiment, basalt feedstock is added to soil columns containing the
cereal crop Sorghum bicolor at a rate equivalent to 50 t ha-1. Using our
approach, we calculate an average initial CDR value of 2.24 +- 1.33 tCO2eq ha-1
from our experiments after 235 days, within error of an independent estimate
calculated using conventional elemental budgeting of reaction products. Our
result corresponds to an initial CDR efficiency of 24.4 +- 14.5 % for the
feedstock used. Our method provides a robust time-integrated estimate of
initial CDR, and offers a path to track and validate large-scale carbon removal
through ERW
Multiple Front Propagation Into Unstable States
The dynamics of transient patterns formed by front propagation in extended
nonequilibrium systems is considered. Under certain circumstances, the state
left behind a front propagating into an unstable homogeneous state can be an
unstable periodic pattern. It is found by a numerical solution of a model of
the Fr\'eedericksz transition in nematic liquid crystals that the mechanism of
decay of such periodic unstable states is the propagation of a second front
which replaces the unstable pattern by a another unstable periodic state with
larger wavelength. The speed of this second front and the periodicity of the
new state are analytically calculated with a generalization of the marginal
stability formalism suited to the study of front propagation into periodic
unstable states. PACS: 47.20.Ky, 03.40.Kf, 47.54.+rComment: 12 page
Radial Star Formation Histories in 32 Nearby Galaxies
The spatially resolved star formation histories are studied for 32 normal
star-forming galaxies drawn from the the Spitzer Extended Disk Galaxy
Exploration Science survey. At surface brightness sensitivities fainter than 28
mag arcsec, the new optical photometry is deep enough to complement
archival ultraviolet and infrared imaging and to explore the properties of the
emission well beyond the traditional optical extents of these nearby galaxies.
Fits to the spectral energy distributions using a delayed star formation
history model indicate a subtle but interesting average radial trend for the
spiral galaxies: the inner stellar systems decrease in age with increasing
radius, consistent with inside-out disk formation, but the trend reverses in
the outermost regions with the stellar age nearly as old as the innermost
stars. These results suggest an old stellar outer disk population formed
through radial migration and/or the cumulative history of minor mergers and
accretions of satellite dwarf galaxies. The subset of S0 galaxies studied here
show the opposite trend compared to what is inferred for spirals:
characteristic stellar ages that are increasingly older with radius for the
inner portions of the galaxies, and increasingly younger stellar ages for the
outer portions. This result suggests that either S0 galaxies are not well
modeled by a delayed- model, and/or that S0 galaxies have a more
complicated formation history than spiral galaxies.Comment: Accepted for publication in the Astronomical Journal. arXiv admin
note: text overlap with arXiv:1511.0328
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