East Asian Financial and Monetary Cooperation and Its Prospect : Beyond the CMI

This paper examines the ASEAN+3 cooperation of regional financial safety nets, and reviews the regional monetary issues of a single currency and currency competition in East Asia. We point out potential systemic risks in East Asia and the importance of regional surveillance. ASEAN+3 regional surveillance should move forward to the stronger measures of peer review and peer pressure, and make the AMRO a well-resourced professional surveillance secretariat to create capacity to apply independent conditionality. To this effective surveillance mechanism, we propose to establish the Board of Coordination to support the ASEAN+3 ERPD by confirming its decision or remitting the relevant case to the ASEAN+3 ERPD and providing possible legal consultation. The institution building of the CMIM secretariat will accelerate the establishment of a regional monetary institution, e.g. an Asian Monetary Fund. The current crisis provides sufficient incentives for East Asian economies to pursue internationalization of their currencies, and it would open the possibility towards a single currency in East Asia.Regional financial safety nets, surveillance mechanism, CMIM, ABMI

A Triple-Mode Performance-Optimized Reconfigurable Incremental ADC for Smart Sensor Applications

This paper proposes a triple-mode discrete-time incremental analog-to-digital converter (IADC) employing successive approximation register (SAR)-based zooming and extended counting (EC) schemes to achieve programmable trade-off capability of resolution and power consumption in various smart sensor applications. It mainly consists of an incremental delta???sigma modulator and the proposed SAR-EC sub-ADC for alternate operation of the coarse SAR conversion and EC. They can be reconfigured to operate separately depending on the application requirements. The SAR-based zooming structure allows the IADC to have better linearity and resolution, and additional activation of the EC function gives the further resolution. During this reconfigurable conversion process, pipelined reusing operation of sub-blocks reduces the silicon area and the number of cycles for target resolutions. A prototype ADC is fabricated in a 180-nm CMOS process, and its triple-mode operation of high-resolution, medium-resolution, and low-power is experimentally verified to achieve 116.1-, 109.4-, and 73.3-dB dynamic ranges, consuming 1.60, 1.26, and 0.39 mW, respectively

Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes.

Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice. Cisplatin increases the catalytic activity of caspase-3 and caspase-8 proteases and the production of free radicals, which were significantly suppressed by pretreatment with bucillamine. Bucillamine induces the intranuclear translocation of Nrf2 and thereby increases the expression of γ-glutamylcysteine synthetase (γ-GCS) and glutathione synthetase (GSS), which further induces intracellular antioxidant glutathione (GSH), heme oxygenase 1 (HO-1) and superoxide dismutase 2 (SOD2). However, knockdown studies of HO-1 and SOD2 suggest that the protective effect of bucillamine against cisplatin is independent of the enzymatic activity of HO-1 and SOD. Furthermore, pretreatment with bucillamine protects sensory hair cells on organ of Corti explants from cisplatin-induced cytotoxicity concomitantly with inhibition of caspase-3 activation. The auditory-brainstem-evoked response of cisplatin-injected mice shows marked increases in hearing threshold shifts, which was markedly suppressed by pretreatment with bucillamine in vivo. Taken together, bucillamine protects sensory hair cells from cisplatin through a scavenging effect on itself, as well as the induction of intracellular GSH

A Score-Based Evaluation Model for Rehabilitation of Existing Pumped Storage Hydropower Plant Construction

As the proportion of new and renewable energy increases, power control demands are becoming more frequent due to variability in power generation. As a complementary means against this, the pumped storage hydropower plants (PSHP) are attracting attention as energy storage systems (ESS), but it has high construction costs. Therefore, this study aims to improve the economic feasibility by developing the evaluation model of the existing infrastructure into an upper/lower dam suitable for PSHP. The concept of upper dam capacity is newly defined, and the evaluation index is constructed using normalization. A new evaluation system is presented for five factors: environment, stability, energy, capacity, and economy. Finally, it is tested in the pilot area in Korea. Several candidates, including the PSHP in operation, are found to have been distributed with higher scores. These results will help to satisfy the selection of candidates during the preliminary feasibility study phase, and programming them will enable more accurate and rapid assessment

Size distributions of atmospheric particulate matter and associated trace metals in the multi-industrial city of Ulsan, Korea

Particulate matter (PM) was collected using micro-orifice uniform deposit impactors from a residential (RES) site and an industrial (IND) site in Ulsan, South Korea, in September-October 2014. The PM samples were measured based on their size distributions (11 stages), ranging from 0.06 ??m to over 18.0 ??m. Nine trace metals (As, Se, Cr, V, Cd, Pb, Ba, Sb, and Zn) associated with PM were analyzed. The PM samples exhibited weak bimodal distributions irrespective of sampling sites and events, and the mean concentrations of total PM (TPM) measured at the IND site (56.7 ??g/m3) was higher than that measured at the RES site (38.2 ??g/m3). The IND site also showed higher levels of nine trace metals, reflecting the influence of industrial activities and traffic emissions. At both sites, four trace metals (Ba, Zn, V, and Cr) contributed to over 80% of the total concentrations in TPM. The modality of individual trace metals was not strong except for Zn; however, the nine trace metals in PM2.5 and PM10 accounted for approximately 50% and 90% of the total concentrations in TPM, respectively. This result indicates that the size distributions of PM and trace metals are important to understand how respirable PM affects public health