557 research outputs found

    Model-based Aeroservoelastic Design and Load Alleviation of Large Wind Turbine Blades

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    This paper presents an aeroservoelastic modeling approach for dynamic load alleviation in large wind turbines with trailing-edge aerodynamic surfaces. The tower, potentially on a moving base, and the rotating blades are modeled using geometrically non-linear composite beams, which are linearized around reference conditions with arbitrarily-large structural displacements. Time-domain aerodynamics are given by a linearized 3-D unsteady vortexlattice method and the resulting dynamic aeroelastic model is written in a state-space formulation suitable for model reductions and control synthesis. A linear model of a single blade is used to design a Linear-Quadratic-Gaussian regulator on its root-bending moments, which is finally shown to provide load reductions of about 20% in closed-loop on the full wind turbine non-linear aeroelastic model

    Nanotomie van huid en mucosa van pemfiguspatiënten

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    Pemphigus is an auto-immune blistering skin and/or mucosal disease caused by antibodies against proteins of desmosomes. Desmosomes are cell-cell adhesion structures that interconnect intermediate filament networks of neighboring cells. The transmembrane desmosomal proteins that are the targets of pemphigus autoantibodies, desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3), are specific for the stratified epithelia of the skin and mucosal membranes and are not present in the simple epithelia. Therefore, loss of cell-cell adhesion (acantholysis) induced by pemphigus autoantibodies and clinically presented as blistering occurs only in these tissues. Two main forms of pemphigus are known: pemphigus vulgaris (PV) and pemphigus foliaceus (PF) with a different clinical picture and a different autoantibody profile. How pemphigus autoantibodies induce loss of cell-cell adhesion is our main question. Large scale electron microscopy ("nanotomy") was applied to study pemphigus patients skin and mucosa. This non-biased technique allows easy exploration of large tissue areas which is not possible by conventional EM. We examined both skin and mucosa of PF and PV patients, focusing on ultrastructural details: localization of blister, presence of half desmosomes and localization of keratin filament network in the cells surrounding the blister and desmosomes and intercellular space in nonlesional layers. In spontaneous lesional PF patient skin no desmosomes were present round the blister, while in Nikolsky positive PF patient skin half desmosomes were observed round the blister. In all lesional pemphigus samples and to a lesser extend in non-lesional samples newly described structures named interdigitations composed out of two neighboring cell membranes were present. These structures were abundant in lesional pemphigus skin, which provides a clue to blister pathogenesis.Open source electron-microscopic maps of pemphigus tissue are freely accessible at www.nanotomy.org

    Analysis and applications of respiratory surface EMG:report of a round table meeting

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    Surface electromyography (sEMG) can be used to measure the electrical activity of the respiratory muscles. The possible applications of sEMG span from patients suffering from acute respiratory failure to patients receiving chronic home mechanical ventilation, to evaluate muscle function, titrate ventilatory support and guide treatment. However, sEMG is mainly used as a monitoring tool for research and its use in clinical practice is still limited—in part due to a lack of standardization and transparent reporting. During this round table meeting, recommendations on data acquisition, processing, interpretation, and potential clinical applications of respiratory sEMG were discussed. This paper informs the clinical researcher interested in respiratory muscle monitoring about the current state of the art on sEMG, knowledge gaps and potential future applications for patients with respiratory failure.</p
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