An analytical solution for the elastoplastic response of a continuous fiber composite under uniaxial loading

A continuous fiber composite is modelled by a two-element composite cylinder in order to predict the elastoplastic response of the composite under a monotonically increasing tensile loading parallel to fibers. The fibers and matrix are assumed to be elastic-perfectly plastic materials obeying Hill's and Tresca's yield criteria, respectively. Here, the composite behavior when the fibers yield prior to the matrix is investigated

Excited Heavy Baryon Masses from the 1/N_c Expansion of HQET

The mass spectra of the L=1 orbitally excited heavy baryons with light quarks in both the spin-flavor symmetric and the mixed representations are studied by the $1/N_c$ expansion method in the framework of the heavy quark effective theory. The mixing effect between the baryons in the two representations is also considered. The general pattern of the spectrum is predicted which will be verified by the experiments in the near future.Comment: 9 pages, latex, no figure, uses sprocl.sty (included). Talk by Chun Liu at the workshop on Non-Perturbative Methods and Lattice QCD (Guangzhou, May 15-21, 2000

Host cell protein control via CHO genome engineering

Chinese hamster ovary (CHO) cells, a major mammalian platform in biomanufacturing, produce and secret recombinant proteins along with host cell proteins (HCPs). Because residual HCPs in the final drug product can adversely affect (1) patients by causing immune responses, (2) drug efficacy, and (3) product stability, the effective removal of HCPs is necessary. Unfortunately, many studies have reported that many HCPs can be difficult to remove through downstream purification processes because they share similar biophysical properties to biopharmaceuticals. In this study we employed a genome engineering approach using clustered regularly interspaced short palindromic repeats and associated protein 9 (CRISPR/Cas9) system-mediated knockout to address difficult-to-remove HCP problems. Three HCPs (Cathepsin D, Nidogen-1, and Prosaposin) that are known to be difficult to remove were selected, and respective knockout clones were isolated without using selective reagents or reporter genes. Clones for each HCP were characterized using various analysis methods. Taken together, we demonstrate the applicability of the CRISPR/Cas9 system to eliminate difficult-to-remove HCP expression in an industry-relevant setting

Medium Effects on Binary Collisions with the Delta Resonance

To facilitate the relativistic heavy-ion calculations based on transport equations, the binary collisions involving a $\Delta$ resonance in either the entrance channel or the exit channel are investigated within a Hamiltonian formulation of $\pi NN$ interactions. An averaging procedure is developed to define a quasi-particle $\Delta^*$ and to express the experimentally measured $NN\rightarrow \pi NN$ cross section in terms of an effective $NN\rightarrow N\Delta^\ast$ cross section. In contrast to previous works, the main feature of the present approach is that the mass and the momentum of the produced $\Delta^*$'s are calculated dynamically from the bare $\Delta \leftrightarrow \pi N$ vertex interaction of the model Hamiltonian and are constrained by the unitarity condition. The procedure is then extended to define the effective cross sections for the experimentally inaccessible $N\Delta^\ast \rightarrow NN$ and $N\Delta^\ast \rightarrow N\Delta^\ast$ reactions. The predicted cross sections are significantly different from what are commonly assumed in relativistic heavy-ion calculations. The $\Delta$ potential in nuclear matter has been calculated by using a Bruckner-Hartree-Fock approximation. By including the mean-field effects on the $\Delta$ propagation, the effective cross sections of the $NN\rightarrow N\Delta^\ast$, $N\Delta^\ast \rightarrow NN$ and $N\Delta^\ast \rightarrow N\Delta^\ast$ reactions in nuclear matter are predicted. It is demonstrated that the density dependence is most dramatic in the energy region close to the pion production threshold.Comment: 20 pages, RevTe

Dynamical Expansion of Ionization and Dissociation Front around a Massive Star. II. On the Generality of Triggered Star Formation

We analyze the dynamical expansion of the HII region, photodissociation region, and the swept-up shell, solving the UV- and FUV-radiative transfer, the thermal and chemical processes in the time-dependent hydrodynamics code. Following our previous paper, we investigate the time evolutions with various ambient number densities and central stars. Our calculations show that basic evolution is qualitatively similar among our models with different parameters. The molecular gas is finally accumulated in the shell, and the gravitational fragmentation of the shell is generally expected. The quantitative differences among models are well understood with analytic scaling relations. The detailed physical and chemical structure of the shell is mainly determined by the incident FUV flux and the column density of the shell, which also follow the scaling relations. The time of shell-fragmentation, and the mass of the gathered molecular gas are sensitive tothe ambient number density. In the case of the lower number density, the shell-fragmentation occurs over a longer timescale, and the accumulated molecular gas is more massive. The variations with different central stars are more moderate. The time of the shell-fragmentation differs by a factor of several with the various stars of M_* = 12-101 M_sun. According to our numerical results, we conclude that the expanding HII region should be an efficient trigger for star formation in molecular clouds if the mass of the ambient molecular material is large enough.Comment: 49 pages, including 17 figures ; Accepted for publication in Ap