58,271 research outputs found

    E-Government: An e-reverse auction case study

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    This paper presents the findings from an exploratory in-depth case study with regard to e- Reverse Auctions (eRAs) in the UK public sector. These findings highlight that eRAs can improve procurement processes, realise cost savings and reduce delivery times. The research also notes that eRAs can produce dis-benefits, including poor buyer and supplier relationships and social implications. The paper elicits lessons learnt from the case study analysis. These are presented with the aim to inform theory and practice

    Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture.

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    We have shown that macrophages in culture degrade the glycoproteins and amorphous elastin of insoluble extracellular matrices. Ultrastructural observation of the macrophage-matrix interaction revealed that connective tissue macromolecules were solubilized from the matrix extracellularly. At least part of the matrix breakdown was localized to the immediate vicinity of the cells, as shown by morphological and biochemical studies, although the rate of degradation correlated closely with the secretion of proteinases by various inflammatory stimuli in vivo, by glucocorticoids, prostaglandin E2 or colchicine, or by phagocytosis of latex, zymosan, or cholesterol-albumin complexes in culture was reflected in altered rates of glycoprotein and elastin degradation by the macrophages. Alteration of endocytosis and lysosomal digestion by cytochalasin B, NH4Cl, and proteinase inhibitors did not decrease the overall rate of matrix solubilization, but reduced the processing of the matrix fragments to peptides. Therefore, extracellular, pericellular, and lysosomal events each contribute to degradation of extracellular matrix macromolecules by inflammatory macrophages

    Application of Web 2.0 technologies in e-government: A United Kingdom case study

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    Electronic government (e-Government) has endured significant transformation over the last decade and currently, it is making further leaps by incorporating modern technologies such as second generation web (Web 2.0) technologies. However, since the development and use of this kind of technology is still at its early stages in the public sector, research about the use of Web 2.0 in this domain is still highly tentative and lacks theoretical underpinning. This paper reports the preliminary findings of an in-depth case study in the United Kingdom (UK) public sector, which explore the application of Web 2.0 technologies in the local government authority (LGA). The findings elicited from the case study offer an insight into information systems (IS) evaluation criterions and impact factors of Web 2.0 from both a practical setting and an internal organisational perspective. This paper concludes that a combined analysis of the evaluation and impact factors rather than a singular approach would better assist the decision making process that leads to effective application of Web 2.0 technologies. It also highlights the significant impact and perceived effect of adoption of such technologies

    E-government evaluation: Reflections on three organisational case studies

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    The deployment of e-Government continues at a significant cost and pace in the worldwide public sector. An important area of research is that of the evaluation of e-Government. In this paper the authors report the findings from three interpretive in-depth organisational case studies that explore e-Government evaluation within UK public sector settings. The paper elicits insights to organisational and managerial aspects with the aim of improving knowledge and understanding of e- Government evaluation. The findings that are extrapolated from the analysis of the three case studies are classified and mapped onto a tentative e-Government evaluation framework and presented in terms lessons learnt. These aim to inform theory and improve e- Government evaluation practice. The paper concludes that e-Government evaluation is an under developed area and calls for senior executives to engage more with the e- Government agenda and commission e-Government evaluation exercises to improve evaluation practice

    Impacts of stratospheric aerosol geoengineering strategy on Caribbean coral reefs

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    Purpose: Currently, negotiation on global carbon emissions reduction is very difficult due to lack of international willingness. In response, geoengineering (climate engineering) strategy is proposed to artificially cool the planet. Meanwhile, as the harbor around one-third of all described marine species, coral reefs are the most sensitive ecosystem on the planet to climate change. However, until now, there is no any quantitative assessment on impacts of geoengineering on coral reefs. In this study, we model impacts of stratospheric aerosol geoengineering on coral reefs. Design/methodology/approach: We will use the HadGEM2-ES climate model to model and evaluate impacts of stratospheric aerosol geoengineering on coral reefs. Findings: This study shows that a) stratospheric aerosol geoengineering could significantly mitigate future coral bleaching throughout the Caribbean Sea; b) Changes in downward solar irradiation, sea level rise and sea surface temperature caused by geoengineering implementation should have very little impacts on coral reefs; c) although geoengineering would prolong the return period of future hurricanes, this may still be too short to ensure coral recruitment and survival after hurricane damage

    Powder Bed Fusion Additive Manufacturing of JBK-75

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    JBK-75 is an iron-nickel derivative alloy of A-286 that has been of interest to NASAs propulsion community for use in fuel injectors and other components that are used in hot, corrosive environments. To enable the rapid production of these components in JBK-75, Marshall Space Flight Center has developed parameters for manufacturing fully dense JBK-75 components using powder bed fusion additive manufacturing (PBFAM). These parameters were developed in a two-step development. First, the depth of laser penetration in the powdered material was measured across a spectrum of laser powers to determine the optimal power necessary for generating the desired meltpool depth. The parameter sets vector-to-vector spacing was then then tailored to guarantee the full densification of the desired area. The results of this development was a readily implementable parameter that produced 99.6% dense material when using a 147W power running at 600mm/s with a 85m(32%) vector-to-vector spacing

    E-Government Evaluation: Reflections on two Organisational studies

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    Senior executives in public sector organisations have been charged with delivering an e-Government agenda. A key emerging area of research is that of the evaluation of e-Government, given that economic factors have traditionally dominated any traditional ICT evaluation process. In this paper the authors report the findings from two interpretive in-depth case studies in the UK public sector, which explore e-Government organisational evaluation within a public sector setting. This paper seeks to offer insights to organisational and managerial aspects surrounding the improvement of knowledge and understanding of e-Government evaluation. The findings that are elicited from the case studies are analysed and presented in terms of a framework derived from organisational analysis to improve e-Government evaluation, with key lessons learnt being extrapolated from practice. The paper concludes that e-Government evaluation is both an under developed and under managed area, and calls for senior executives to engage more with the e-Government agenda and for organisations to review e-Government evaluation to improve evaluation practice

    Benchmark ultra-cool dwarfs in widely separated binary systems

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    Ultra-cool dwarfs as wide companions to subgiants, giants, white dwarfs and main sequence stars can be very good benchmark objects, for which we can infer physical properties with minimal reference to theoretical models, through association with the primary stars. We have searched for benchmark ultra-cool dwarfs in widely separated binary systems using SDSS, UKIDSS, and 2MASS. We then estimate spectral types using SDSS spectroscopy and multi-band colors, place constraints on distance, and perform proper motions calculations for all candidates which have sufficient epoch baseline coverage. Analysis of the proper motion and distance constraints show that eight of our ultra-cool dwarfs are members of widely separated binary systems. Another L3.5 dwarf, SDSS 0832, is shown to be a companion to the bright K3 giant Eta Cancri. Such primaries can provide age and metallicity constraints for any companion objects, yielding excellent benchmark objects. This is the first wide ultra-cool dwarf + giant binary system identified.Comment: 4 pages, 3 figures, conference, "New Technologies for Probing the Diversity of Brown Dwarfs and Exoplanets", oral tal
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