A new apparatus for determining the shrinkage limit of clay soils

A new apparatus for the determination of shrinkage limit is described. Two versions have been produced: a manually operated prototype ‘version1' followed by an automated version named SHRINKiT. Test results using the former for British and overseas clay soils are described and comparisons made with the British Standards preferred method. A further set of test results is described for SHRINKiT. However, it was not possible to compare these with the BS 1377 method owing to the introduction of a ban on the use of mercury in the British Geological Survey's geotechnical laboratories. The new method is set in the context of the huge cost of shrink/swell-related subsidence damage in Britain and the relative disuse of both BS 1377 methods for shrinkage limit, for reasons of safety. The shrinkage behaviour of different soils types and sample states is discussed, in addition to the advantages and disadvantages of the new method

Arctic ocean shelf-basin interaction: An active continental shelf CO2 pump and its impact on the degree of calcium carbonate solubility

The Arctic Ocean has wide shelf areas with extensive biological activity including a high primary productivity and an active microbial loop within the surface sediment. This in combination with brine production during sea ice formation result in the decay products exiting from the shelf into the deep basin typically at a depth of about 150 m and over a wide salinity range centered around S not, vert, similar33. We present data from the Beringia cruise in 2005 along a section in the Canada Basin from the continental margin north of Alaska towards the north and from the International Siberian Shelf Study in 2008 (ISSS-08) to illustrate the impact of these processes. The water rich in decay products, nutrients and dissolved inorganic carbon (DIC), exits the shelf not only from the Chukchi Sea, as has been shown earlier, but also from the East Siberian Sea. The excess of DIC found in the Canada Basin in a depth range of about 50–250 m amounts to 90±40 g C m−2. If this excess is integrated over the whole Canadian Basin the excess equals 320±140×1012 g C. The high DIC concentration layer also has low pH and consequently a low degree of calcium carbonate saturation, with minimum aragonite values of 60% saturation and calcite values just below saturation. The mean age of the waters in the top 300 m was calculated using the transit time distribution method. By applying a future exponential increase of atmospheric CO2 the invasion of anthropogenic carbon into these waters will result in an under-saturated surface water with respect to aragonite by the year 2050, even without any freshening caused by melting sea ice or increased river discharge

Use of inhaled imipenem/cilastatin in pediatric patients with cystic fibrosis: A case series

Mycobacterium abscessus is a rapidly-growing, virulent, non-tuberculous mycobacterium that causes progressive inflammatory lung damage and significant decline in lung functionin patients with cystic fibrosis. M. abscessus complex pulmonary infections are notoriously difficult to treat, and while many antibiotics are approved for children, drug allergies or intolerances can prohibit their use. Intravenous imipenem/cilastatin is among the preferred antibiotics for treatment of M. abscessus, however, its use may result in systemic toxicities including hepatic injury and gastrointestinal effects. Case reports document the successful use of inhaled imipenem/cilastatin in adult cystic fibrosis and non- cystic fibrosis patients with non- M. abscessus pulmonary infections. To our knowledge, similar evidence does not exist for pediatric patients. In this case series, we describe two pediatric patients with cystic fibrosis and previous intolerance or lack of response to standard therapies who received inhaled imipenem/cilastatin for the treatment of chronic M. abscessus infection

Primary Care Nurse Practitioner Wage Differences by Employment Setting

Background: Previous studies reported that primary care nurse practitioners working in primary care settings may earn less than those working in specialty care settings. However, few studies have examined why such wage difference exists. Purpose: This study used human capital theory to determine the degree to which the wage differences between dings PCNPs working in primary care versus specialty care settings is driven by the differences in PCNPs’ characteristics. Feasible generalized least squares regression was used to examine the wage differences for PCNPs working in primary care and specialty care settings. Methods: A cross-sectional, secondary data analysis was conducted using the restricted file of 2012 National Sample Survey of Nurse Practitioners. Findings: Oaxaca-Blinder decomposition technique was used to explore the factors contributing to wage differences. The results suggested that hourly wages of PCNPs working in primary care settings were, on average, 7.1% lower than PCNPs working in specialty care settings, holding PCNPs’ socio-demographic, human capital, and employment characteristics constant. Approximately 4% of this wage difference was explained by PCNPs’ characteristics; but 96% of these differences were due to unexplained factors. Discussion: A large, unexplained wage difference exists between PCNPs working in primary care and specialty care settings

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation

The structure-specific endonuclease XPF-ERCC1 participates in multiple DNA damage repair pathways including nucleotide excision repair (NER) and in¬ter-strand crosslink repair (ICLR). How XPF-ERCC1 is catalytically activated by DNA junction substrates is not currently understood. Here we report cryo-electron mi¬croscopy structures of both DNA-free and DNA-bound human XPF-ERCC1. DNA-free XPF-ERCC1 adopts an auto-inhibited conformation in which the XPF heli¬cal domain masks the ERCC1 (HhH)2 domain and restricts access to the XPF catalytic site. DNA junction engagement releases the ERCC1 (HhH)2 domain to couple with the XPF-ERCC1 nuclease/nuclease-like domains. Structure-function data indicate xeroderma pigmentosum patient mutations frequently compromise the structural integrity of XPF-ERCC1. Fanconi anaemia patient mutations often display sub¬stantial in-vitro activity but are resistant to activation by ICLR recruitment factor SLX4. Our data provide insights into XPF-ERCC1 architecture and catalytic activation

Travelling waves for the Gross-Pitaevskii equation II

The purpose of this paper is to provide a rigorous mathematical proof of the existence of travelling wave solutions to the Gross-Pitaevskii equation in dimensions two and three. Our arguments, based on minimization under constraints, yield a full branch of solutions, and extend earlier results, where only a part of the branch was built. In dimension three, we also show that there are no travelling wave solutions of small energy.Comment: Final version accepted for publication in Communications in Mathematical Physics with a few minor corrections and added remark

Poor Sleep and Impaired Self-Care: Towards a Comprehensive Model Linking Sleep, Cognition, and Heart Failure Outcomes

Background: Persons with heart failure (HF) have significantly lower sleep quantity and quality than persons without HF. The purpose of this article is to propose a conceptual model describing how poor sleep may contribute to inadequate self-care and untoward outcomes in persons with HF. Aims: Our overarching hypothesis is that sleep affects self-care and outcomes through its effects on cognition. Building on the work of others, we outline a conceptual model that illustrates that even transient sleep disruption prevents sleep-related restorative processes and contributes to cognitive dysfunction—especially in the 25–50% of HF patients with existing cognitive impairment. Poor sleep may be sufficient to impair cognition to a level that interferes with higher order functions involved in effective HF self-care practices. Through these mechanisms, inadequate sleep may contribute to poor outcomes such as low health-related quality of life and greater risk of unplanned hospitalization. Conclusion: The proposed model (1) bridges physical, neuropsychological and behavioral phenomena, (2) suggests a mechanism by which poor sleep affects daytime behavior, and (3) is empirically testable. Exploring factors that interfere with sleep may improve self-care and outcomes in persons with HF

Wind-driven export of Weddell Sea slope water

The export of waters from the Weddell Gyre to lower latitudes is an integral component of the southern subpolar contribution to the three-dimensional oceanic circulation. Here we use more than 20 years of repeat hydrographic data on the continental slope on the northern tip of the Antarctic Peninsula and 5 years of bottom lander data on the slope at 1000 m to show the intermittent presence of a relatively cold, fresh, westward flowing current. This is often bottom-intensified between 600 and 2000 dbar with velocities of over 20 cm s−1, transporting an average of 1.5 ± 1.5 Sv. By comparison with hydrography on the continental slope within the Weddell Sea and modeled tracer release experiments we show that this slope current is an extension of the Antarctic Slope Current that has crossed the South Scotia Ridge west of Orkney Plateau. On monthly to interannual time scales the density of the slope current is negatively correlated (r > 0.6 with a significance of over 95%) with eastward wind stress over the northern Weddell Sea, but lagging it by 6–13 months. This relationship holds in both the high temporal resolution bottom lander time series and the 20+ year annual hydrographic occupations and agrees with Weddell Sea export variability observed further east. We compare several alternative hypotheses for this wind stress/export relationship and find that it is most consistent with wind-driven acceleration of the gyre boundary current, possibly modulated by eddy dynamics, and represents a mechanism by which climatic perturbations can be rapidly transmitted as fluctuations in the supply of intermediate-level waters to lower latitudes

Hyperspherical partial wave theory applied to electron hydrogen-atom ionization calculation for equal energy sharing kinematics

Hyperspherical partial wave theory has been applied here in a new way in the calculation of the triple differential cross sections for the ionization of hydrogen atoms by electron impact at low energies for various equal-energy-sharing kinematic conditions. The agreement of the cross section results with the recent absolute measurements of R\"oder \textit {et al} [51] and with the latest theoretical results of the ECS and CCC calculations [29] for different kinematic conditions at 17.6 eV is very encouraging. The other calculated results, for relatively higher energies, are also generally satisfactory, particularly for large $\Theta_{ab}$ geometries. In view of the present results, together with the fact that it is capable of describing unequal-energy-sharing kinematics [35], it may be said that the hyperspherical partial wave theory is quite appropriate for the description of ionization events of electron-hydrogen type systems. It is also clear that the present approach in the implementation of the hyperspherical partial wave theory is very appropriate.Comment: 16 pages, 9 figures, LaTeX file and EPS figures. To appear in Phys. Rev.

Is symmetry identity?

Wigner found unreasonable the "effectiveness of mathematics in the natural sciences". But if the mathematics we use to describe nature is simply a coded expression of our experience then its effectiveness is quite reasonable. Its effectiveness is built into its design. We consider group theory, the logic of symmetry. We examine the premise that symmetry is identity; that group theory encodes our experience of identification. To decide whether group theory describes the world in such an elemental way we catalogue the detailed correspondence between elements of the physical world and elements of the formalism. Providing an unequivocal match between concept and mathematical statement completes the case. It makes effectiveness appear reasonable. The case that symmetry is identity is a strong one but it is not complete. The further validation required suggests that unexpected entities might be describable by the irreducible representations of group theory